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140 related items for PubMed ID: 14966129
21. High-glucose toxicity is mediated by AICAR-transformylase/IMP cyclohydrolase and mitigated by AMP-activated protein kinase in Caenorhabditis elegans. Riedinger C, Mendler M, Schlotterer A, Fleming T, Okun J, Hammes HP, Herzig S, Nawroth PP. J Biol Chem; 2018 Mar 30; 293(13):4845-4859. PubMed ID: 29414769 [Abstract] [Full Text] [Related]
22. Analysis of substrate binding in individual active sites of bifunctional human ATIC. Witkowska D, Cox HL, Hall TC, Wildsmith GC, Machin DC, Webb ME. Biochim Biophys Acta Proteins Proteom; 2018 Feb 30; 1866(2):254-263. PubMed ID: 29042184 [Abstract] [Full Text] [Related]
23. Targeting tumour proliferation with a small-molecule inhibitor of AICAR transformylase homodimerization. Spurr IB, Birts CN, Cuda F, Benkovic SJ, Blaydes JP, Tavassoli A. Chembiochem; 2012 Jul 23; 13(11):1628-34. PubMed ID: 22764122 [Abstract] [Full Text] [Related]
24. AICAR transformylase/IMP cyclohydrolase (ATIC) is essential for de novo purine biosynthesis and infection by Cryptococcus neoformans. Wizrah MSI, Chua SMH, Luo Z, Manik MK, Pan M, Whyte JML, Robertson AAB, Kappler U, Kobe B, Fraser JA. J Biol Chem; 2022 Oct 23; 298(10):102453. PubMed ID: 36063996 [Abstract] [Full Text] [Related]
28. 10-(2-benzoxazolcarbonyl)-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid: a potential inhibitor of GAR transformylase and AICAR transformylase. Marsilje TH, Hedrick MP, Desharnais J, Capps K, Tavassoli A, Zhang Y, Wilson IA, Benkovic SJ, Boger DL. Bioorg Med Chem; 2003 Oct 01; 11(20):4503-9. PubMed ID: 13129586 [Abstract] [Full Text] [Related]
29. Structure and functional relationships in human pur H. Beardsley GP, Rayl EA, Gunn K, Moroson BA, Seow H, Anderson KS, Vergis J, Fleming K, Worland S, Condon B, Davies J. Adv Exp Med Biol; 1998 Oct 01; 431():221-6. PubMed ID: 9598063 [Abstract] [Full Text] [Related]
30. The human purH gene product, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. Cloning, sequencing, expression, purification, kinetic analysis, and domain mapping. Rayl EA, Moroson BA, Beardsley GP. J Biol Chem; 1996 Jan 26; 271(4):2225-33. PubMed ID: 8567683 [Abstract] [Full Text] [Related]
31. AICA-ribosiduria: a novel, neurologically devastating inborn error of purine biosynthesis caused by mutation of ATIC. Marie S, Heron B, Bitoun P, Timmerman T, Van Den Berghe G, Vincent MF. Am J Hum Genet; 2004 Jun 26; 74(6):1276-81. PubMed ID: 15114530 [Abstract] [Full Text] [Related]
33. Structure-based design, synthesis, evaluation, and crystal structures of transition state analogue inhibitors of inosine monophosphate cyclohydrolase. Xu L, Chong Y, Hwang I, D'Onofrio A, Amore K, Beardsley GP, Li C, Olson AJ, Boger DL, Wilson IA. J Biol Chem; 2007 Apr 27; 282(17):13033-46. PubMed ID: 17324932 [Abstract] [Full Text] [Related]
34. Identification of ATIC as a Novel Target for Chemoradiosensitization. Liu X, Paila UD, Teraoka SN, Wright JA, Huang X, Quinlan AR, Gatti RA, Concannon P. Int J Radiat Oncol Biol Phys; 2018 Jan 01; 100(1):162-173. PubMed ID: 29029884 [Abstract] [Full Text] [Related]
35. Associations of common polymorphisms in the thymidylate synthase, reduced folate carrier and 5-aminoimidazole-4-carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase genes with folate and homocysteine levels and venous thrombosis risk. Gellekink H, Blom HJ, den Heijer M. Clin Chem Lab Med; 2007 Jan 01; 45(4):471-6. PubMed ID: 17439323 [Abstract] [Full Text] [Related]
36. Rational design, synthesis, evaluation, and crystal structure of a potent inhibitor of human GAR Tfase: 10-(trifluoroacetyl)-5,10-dideazaacyclic-5,6,7,8-tetrahydrofolic acid. Zhang Y, Desharnais J, Marsilje TH, Li C, Hedrick MP, Gooljarsingh LT, Tavassoli A, Benkovic SJ, Olson AJ, Boger DL, Wilson IA. Biochemistry; 2003 May 27; 42(20):6043-56. PubMed ID: 12755606 [Abstract] [Full Text] [Related]
37. 10-Formyl-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid (10-formyl-DDACTHF): a potent cytotoxic agent acting by selective inhibition of human GAR Tfase and the de novo purine biosynthetic pathway. Marsilje TH, Labroli MA, Hedrick MP, Jin Q, Desharnais J, Baker SJ, Gooljarsingh LT, Ramcharan J, Tavassoli A, Zhang Y, Wilson IA, Beardsley GP, Benkovic SJ, Boger DL. Bioorg Med Chem; 2002 Aug 27; 10(8):2739-49. PubMed ID: 12057663 [Abstract] [Full Text] [Related]
38. The apo and ternary complex structures of a chemotherapeutic target: human glycinamide ribonucleotide transformylase. Dahms TE, Sainz G, Giroux EL, Caperelli CA, Smith JL. Biochemistry; 2005 Jul 26; 44(29):9841-50. PubMed ID: 16026156 [Abstract] [Full Text] [Related]
39. The enzymatic activity of 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase is enhanced by NPM-ALK: new insights in ALK-mediated pathogenesis and the treatment of ALCL. Boccalatte FE, Voena C, Riganti C, Bosia A, D'Amico L, Riera L, Cheng M, Ruggeri B, Jensen ON, Goss VL, Lee K, Nardone J, Rush J, Polakiewicz RD, Comb MJ, Chiarle R, Inghirami G. Blood; 2009 Mar 19; 113(12):2776-90. PubMed ID: 18845790 [Abstract] [Full Text] [Related]
40. Inhibition of 5-aminoimidazole-4-carboxamide ribotide transformylase, adenosine deaminase and 5'-adenylate deaminase by polyglutamates of methotrexate and oxidized folates and by 5-aminoimidazole-4-carboxamide riboside and ribotide. Baggott JE, Vaughn WH, Hudson BB. Biochem J; 1986 May 15; 236(1):193-200. PubMed ID: 2431676 [Abstract] [Full Text] [Related] Page: [Previous] [Next] [New Search]