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PUBMED FOR HANDHELDS

Journal Abstract Search


946 related items for PubMed ID: 14974085

  • 1. Noonan syndrome-associated SHP2/PTPN11 mutants cause EGF-dependent prolonged GAB1 binding and sustained ERK2/MAPK1 activation.
    Fragale A, Tartaglia M, Wu J, Gelb BD.
    Hum Mutat; 2004 Mar; 23(3):267-77. PubMed ID: 14974085
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  • 2. Requirement of SHP2 binding to Grb2-associated binder-1 for mitogen-activated protein kinase activation in response to lysophosphatidic acid and epidermal growth factor.
    Cunnick JM, Dorsey JF, Munoz-Antonia T, Mei L, Wu J.
    J Biol Chem; 2000 May 05; 275(18):13842-8. PubMed ID: 10788507
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  • 3. Activating mutations of the noonan syndrome-associated SHP2/PTPN11 gene in human solid tumors and adult acute myelogenous leukemia.
    Bentires-Alj M, Paez JG, David FS, Keilhack H, Halmos B, Naoki K, Maris JM, Richardson A, Bardelli A, Sugarbaker DJ, Richards WG, Du J, Girard L, Minna JD, Loh ML, Fisher DE, Velculescu VE, Vogelstein B, Meyerson M, Sellers WR, Neel BG.
    Cancer Res; 2004 Dec 15; 64(24):8816-20. PubMed ID: 15604238
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  • 6. Phosphotyrosines 627 and 659 of Gab1 constitute a bisphosphoryl tyrosine-based activation motif (BTAM) conferring binding and activation of SHP2.
    Cunnick JM, Mei L, Doupnik CA, Wu J.
    J Biol Chem; 2001 Jun 29; 276(26):24380-7. PubMed ID: 11323411
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  • 7. Activation of gp130 transduces hypertrophic signal through interaction of scaffolding/docking protein Gab1 with tyrosine phosphatase SHP2 in cardiomyocytes.
    Nakaoka Y, Nishida K, Fujio Y, Izumi M, Terai K, Oshima Y, Sugiyama S, Matsuda S, Koyasu S, Yamauchi-Takihara K, Hirano T, Kawase I, Hirota H.
    Circ Res; 2003 Aug 08; 93(3):221-9. PubMed ID: 12855672
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  • 10. TNF-alpha induces tyrosine phosphorylation and recruitment of the Src homology protein-tyrosine phosphatase 2 to the gp130 signal-transducing subunit of the IL-6 receptor complex.
    Bode JG, Schweigart J, Kehrmann J, Ehlting C, Schaper F, Heinrich PC, Häussinger D.
    J Immunol; 2003 Jul 01; 171(1):257-66. PubMed ID: 12817006
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  • 12. SH2 domain containing protein tyrosine phosphatase 2 regulates concanavalin A-dependent secretion and activation of matrix metalloproteinase 2 via the extracellular signal-regulated kinase and p38 pathways.
    Ruhul Amin AR, Oo ML, Senga T, Suzuki N, Feng GS, Hamaguchi M.
    Cancer Res; 2003 Oct 01; 63(19):6334-9. PubMed ID: 14559821
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  • 15. Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation.
    Hadari YR, Kouhara H, Lax I, Schlessinger J.
    Mol Cell Biol; 1998 Jul 01; 18(7):3966-73. PubMed ID: 9632781
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  • 16. Noonan syndrome mutation Q79R in Shp2 increases proliferation of valve primordia mesenchymal cells via extracellular signal-regulated kinase 1/2 signaling.
    Krenz M, Yutzey KE, Robbins J.
    Circ Res; 2005 Oct 14; 97(8):813-20. PubMed ID: 16166557
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  • 19. Mediating ERK 1/2 signaling rescues congenital heart defects in a mouse model of Noonan syndrome.
    Nakamura T, Colbert M, Krenz M, Molkentin JD, Hahn HS, Dorn GW, Robbins J.
    J Clin Invest; 2007 Aug 14; 117(8):2123-32. PubMed ID: 17641779
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  • 20. Roles of Gab1 and SHP2 in paxillin tyrosine dephosphorylation and Src activation in response to epidermal growth factor.
    Ren Y, Meng S, Mei L, Zhao ZJ, Jove R, Wu J.
    J Biol Chem; 2004 Feb 27; 279(9):8497-505. PubMed ID: 14665621
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