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385 related items for PubMed ID: 14976183

  • 1. RGS2 binds directly and selectively to the M1 muscarinic acetylcholine receptor third intracellular loop to modulate Gq/11alpha signaling.
    Bernstein LS, Ramineni S, Hague C, Cladman W, Chidiac P, Levey AI, Hepler JR.
    J Biol Chem; 2004 May 14; 279(20):21248-56. PubMed ID: 14976183
    [Abstract] [Full Text] [Related]

  • 2. Differential contribution of GTPase activation and effector antagonism to the inhibitory effect of RGS proteins on Gq-mediated signaling in vivo.
    Anger T, Zhang W, Mende U.
    J Biol Chem; 2004 Feb 06; 279(6):3906-15. PubMed ID: 14630933
    [Abstract] [Full Text] [Related]

  • 3. Single-cell imaging of intracellular Ca2+ and phospholipase C activity reveals that RGS 2, 3, and 4 differentially regulate signaling via the Galphaq/11-linked muscarinic M3 receptor.
    Tovey SC, Willars GB.
    Mol Pharmacol; 2004 Dec 06; 66(6):1453-64. PubMed ID: 15383626
    [Abstract] [Full Text] [Related]

  • 4. Alternative splicing of RGS8 gene changes the binding property to the M1 muscarinic receptor to confer receptor type-specific Gq regulation.
    Itoh M, Nagatomo K, Kubo Y, Saitoh O.
    J Neurochem; 2006 Dec 06; 99(6):1505-16. PubMed ID: 17064349
    [Abstract] [Full Text] [Related]

  • 5. Unique hydrophobic extension of the RGS2 amphipathic helix domain imparts increased plasma membrane binding and function relative to other RGS R4/B subfamily members.
    Gu S, He J, Ho WT, Ramineni S, Thal DM, Natesh R, Tesmer JJ, Hepler JR, Heximer SP.
    J Biol Chem; 2007 Nov 09; 282(45):33064-75. PubMed ID: 17848575
    [Abstract] [Full Text] [Related]

  • 6. Selective inhibition of alpha1A-adrenergic receptor signaling by RGS2 association with the receptor third intracellular loop.
    Hague C, Bernstein LS, Ramineni S, Chen Z, Minneman KP, Hepler JR.
    J Biol Chem; 2005 Jul 22; 280(29):27289-95. PubMed ID: 15917235
    [Abstract] [Full Text] [Related]

  • 7. RGS3 is a GTPase-activating protein for g(ialpha) and g(qalpha) and a potent inhibitor of signaling by GTPase-deficient forms of g(qalpha) and g(11alpha).
    Scheschonka A, Dessauer CW, Sinnarajah S, Chidiac P, Shi CS, Kehrl JH.
    Mol Pharmacol; 2000 Oct 22; 58(4):719-28. PubMed ID: 10999941
    [Abstract] [Full Text] [Related]

  • 8. Regulator of G protein signaling 2 (RGS2) and RGS4 form distinct G protein-dependent complexes with protease activated-receptor 1 (PAR1) in live cells.
    Ghil S, McCoy KL, Hepler JR.
    PLoS One; 2014 Oct 22; 9(4):e95355. PubMed ID: 24743392
    [Abstract] [Full Text] [Related]

  • 9. The Gbeta5-RGS7 complex selectively inhibits muscarinic M3 receptor signaling via the interaction between the third intracellular loop of the receptor and the DEP domain of RGS7.
    Sandiford SL, Slepak VZ.
    Biochemistry; 2009 Mar 17; 48(10):2282-9. PubMed ID: 19182865
    [Abstract] [Full Text] [Related]

  • 10. Structural determinants of G-protein alpha subunit selectivity by regulator of G-protein signaling 2 (RGS2).
    Kimple AJ, Soundararajan M, Hutsell SQ, Roos AK, Urban DJ, Setola V, Temple BR, Roth BL, Knapp S, Willard FS, Siderovski DP.
    J Biol Chem; 2009 Jul 17; 284(29):19402-11. PubMed ID: 19478087
    [Abstract] [Full Text] [Related]

  • 11. Structure of the Regulator of G Protein Signaling 8 (RGS8)-Gαq Complex: MOLECULAR BASIS FOR Gα SELECTIVITY.
    Taylor VG, Bommarito PA, Tesmer JJ.
    J Biol Chem; 2016 Mar 04; 291(10):5138-45. PubMed ID: 26755720
    [Abstract] [Full Text] [Related]

  • 12. Active Galpha(q) subunits and M3 acetylcholine receptors promote distinct modes of association of RGS2 with the plasma membrane.
    Clark MA, Sethi PR, Lambert NA.
    FEBS Lett; 2007 Feb 20; 581(4):764-70. PubMed ID: 17275815
    [Abstract] [Full Text] [Related]

  • 13. Characterization of the GRK2 binding site of Galphaq.
    Day PW, Tesmer JJ, Sterne-Marr R, Freeman LC, Benovic JL, Wedegaertner PB.
    J Biol Chem; 2004 Dec 17; 279(51):53643-52. PubMed ID: 15471870
    [Abstract] [Full Text] [Related]

  • 14. Lack of receptor-selective effects of either RGS2, RGS3 or RGS4 on muscarinic M3- and gonadotropin-releasing hormone receptor-mediated signalling through G alpha q/11.
    Karakoula A, Tovey SC, Brighton PJ, Willars GB.
    Eur J Pharmacol; 2008 Jun 10; 587(1-3):16-24. PubMed ID: 18457830
    [Abstract] [Full Text] [Related]

  • 15. Differential interaction of GRK2 with members of the G alpha q family.
    Day PW, Carman CV, Sterne-Marr R, Benovic JL, Wedegaertner PB.
    Biochemistry; 2003 Aug 05; 42(30):9176-84. PubMed ID: 12885252
    [Abstract] [Full Text] [Related]

  • 16. RGS protein specificity towards Gq- and Gi/o-mediated ERK 1/2 and Akt activation, in vitro.
    Anger T, Klintworth N, Stumpf C, Daniel WG, Mende U, Garlichs CD.
    J Biochem Mol Biol; 2007 Nov 30; 40(6):899-910. PubMed ID: 18047785
    [Abstract] [Full Text] [Related]

  • 17. G protein selectivity is a determinant of RGS2 function.
    Heximer SP, Srinivasa SP, Bernstein LS, Bernard JL, Linder ME, Hepler JR, Blumer KJ.
    J Biol Chem; 1999 Nov 26; 274(48):34253-9. PubMed ID: 10567399
    [Abstract] [Full Text] [Related]

  • 18. Serum response factor activation by muscarinic receptors via RhoA. Novel pathway specific to M1 subtype involving calmodulin, calcineurin, and Pyk2.
    Lin K, Wang D, Sadée W.
    J Biol Chem; 2002 Oct 25; 277(43):40789-98. PubMed ID: 12200418
    [Abstract] [Full Text] [Related]

  • 19. Regulation of cardiomyocyte signaling by RGS proteins: differential selectivity towards G proteins and susceptibility to regulation.
    Hao J, Michalek C, Zhang W, Zhu M, Xu X, Mende U.
    J Mol Cell Cardiol; 2006 Jul 25; 41(1):51-61. PubMed ID: 16756988
    [Abstract] [Full Text] [Related]

  • 20. Protein kinase C phosphorylates RGS2 and modulates its capacity for negative regulation of Galpha 11 signaling.
    Cunningham ML, Waldo GL, Hollinger S, Hepler JR, Harden TK.
    J Biol Chem; 2001 Feb 23; 276(8):5438-44. PubMed ID: 11063746
    [Abstract] [Full Text] [Related]

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