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Journal Abstract Search

115 related items for PubMed ID: 14979722

  • 1. Biochemical basis of polyvalency as a strategy for enhancing the efficacy of P-glycoprotein (ABCB1) modulators: stipiamide homodimers separated with defined-length spacers reverse drug efflux with greater efficacy.
    Sauna ZE, Andrus MB, Turner TM, Ambudkar SV.
    Biochemistry; 2004 Mar 02; 43(8):2262-71. PubMed ID: 14979722
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  • 3. A single amino acid residue contributes to distinct mechanisms of inhibition of the human multidrug transporter by stereoisomers of the dopamine receptor antagonist flupentixol.
    Dey S, Hafkemeyer P, Pastan I, Gottesman MM.
    Biochemistry; 1999 May 18; 38(20):6630-9. PubMed ID: 10350482
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  • 6. N-ethylmaleimide increases P-glycoprotein photoaffinity labeling with iodoaryl-azidoprazosin in multidrug resistant cells.
    Wang Y, Georges E.
    Anticancer Res; 1997 May 18; 17(1A):357-64. PubMed ID: 9066677
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  • 7. Drug binding and nucleotide hydrolyzability are essential requirements in the vanadate-induced inhibition of the human P-glycoprotein ATPase.
    Rao US.
    Biochemistry; 1998 Oct 20; 37(42):14981-8. PubMed ID: 9778376
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  • 8. Gomisin A alters substrate interaction and reverses P-glycoprotein-mediated multidrug resistance in HepG2-DR cells.
    Wan CK, Zhu GY, Shen XL, Chattopadhyay A, Dey S, Fong WF.
    Biochem Pharmacol; 2006 Sep 28; 72(7):824-37. PubMed ID: 16889754
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  • 9. Allosteric modulation of the human P-glycoprotein involves conformational changes mimicking catalytic transition intermediates.
    Ghosh P, Moitra K, Maki N, Dey S.
    Arch Biochem Biophys; 2006 Jun 01; 450(1):100-12. PubMed ID: 16624245
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  • 10. Evidence for two nonidentical drug-interaction sites in the human P-glycoprotein.
    Dey S, Ramachandra M, Pastan I, Gottesman MM, Ambudkar SV.
    Proc Natl Acad Sci U S A; 1997 Sep 30; 94(20):10594-9. PubMed ID: 9380680
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  • 12. Analysis of random recombination between human MDR1 and mouse mdr1a cDNA in a pHaMDR-dihydrofolate reductase bicistronic expression system.
    Shoshani T, Zhang S, Dey S, Pastan I, Gottesman MM.
    Mol Pharmacol; 1998 Oct 30; 54(4):623-30. PubMed ID: 9765504
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  • 14. Flavonoid dimers as bivalent modulators for P-glycoprotein-based multidrug resistance: synthetic apigenin homodimers linked with defined-length poly(ethylene glycol) spacers increase drug retention and enhance chemosensitivity in resistant cancer cells.
    Chan KF, Zhao Y, Burkett BA, Wong IL, Chow LM, Chan TH.
    J Med Chem; 2006 Nov 16; 49(23):6742-59. PubMed ID: 17154505
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  • 15. Both ATP sites of human P-glycoprotein are essential but not symmetric.
    Hrycyna CA, Ramachandra M, Germann UA, Cheng PW, Pastan I, Gottesman MM.
    Biochemistry; 1999 Oct 19; 38(42):13887-99. PubMed ID: 10529234
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  • 16. Biochemical mechanism of modulation of human P-glycoprotein (ABCB1) by curcumin I, II, and III purified from Turmeric powder.
    Chearwae W, Anuchapreeda S, Nandigama K, Ambudkar SV, Limtrakul P.
    Biochem Pharmacol; 2004 Nov 15; 68(10):2043-52. PubMed ID: 15476675
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  • 17. In vitro p-glycoprotein inhibition assays for assessment of clinical drug interaction potential of new drug candidates: a recommendation for probe substrates.
    Rautio J, Humphreys JE, Webster LO, Balakrishnan A, Keogh JP, Kunta JR, Serabjit-Singh CJ, Polli JW.
    Drug Metab Dispos; 2006 May 15; 34(5):786-92. PubMed ID: 16455806
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  • 20. Catalytic cycle of ATP hydrolysis by P-glycoprotein: evidence for formation of the E.S reaction intermediate with ATP-gamma-S, a nonhydrolyzable analogue of ATP.
    Sauna ZE, Kim IW, Nandigama K, Kopp S, Chiba P, Ambudkar SV.
    Biochemistry; 2007 Dec 04; 46(48):13787-99. PubMed ID: 17988154
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