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Journal Abstract Search

130 related items for PubMed ID: 14980625

  • 1. Design and synthesis of novel imidazo[1,2-a]quinoxalines as PDE4 inhibitors.
    Deleuze-Masquéfa C, Gerebtzoff G, Subra G, Fabreguettes JR, Ovens A, Carraz M, Strub MP, Bompart J, George P, Bonnet PA.
    Bioorg Med Chem; 2004 Mar 01; 12(5):1129-39. PubMed ID: 14980625
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  • 2. Synthesis of 7-benzylamino-6-chloro-2-piperazino-4-pyrrolidinopteridine and novel derivatives free of positional isomers. Potent inhibitors of cAMP-specific phosphodiesterase and of malignant tumor cell growth.
    Merz KH, Marko D, Regiert T, Reiss G, Frank W, Eisenbrand G.
    J Med Chem; 1998 Nov 19; 41(24):4733-43. PubMed ID: 9822544
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  • 3. Discovery of thiadiazoles as a novel structural class of potent and selective PDE7 inhibitors. Part 1: design, synthesis and structure-activity relationship studies.
    Vergne F, Bernardelli P, Lorthiois E, Pham N, Proust E, Oliveira C, Mafroud AK, Royer F, Wrigglesworth R, Schellhaas J, Barvian M, Moreau F, Idrissi M, Tertre A, Bertin B, Coupe M, Berna P, Soulard P.
    Bioorg Med Chem Lett; 2004 Sep 20; 14(18):4607-13. PubMed ID: 15324874
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  • 4. 2,1,3-Benzothiadiazine derivatives: synthesis and screening versus PDE4 enzyme.
    Tait A, Luppi A, Avallone R, Baraldi M.
    Farmaco; 2005 Aug 20; 60(8):653-63. PubMed ID: 15963514
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  • 8. Synthesis and structure-activity relationships of cis-tetrahydrophthalazinone/pyridazinone hybrids: a novel series of potent dual PDE3/PDE4 inhibitory agents.
    Van der Mey M, Bommelé KM, Boss H, Hatzelmann A, Van Slingerland M, Sterk GJ, Timmerman H.
    J Med Chem; 2003 May 08; 46(10):2008-16. PubMed ID: 12723963
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  • 10. Effects of ciclamilast, a new PDE 4 PDE4 inhibitor, on airway hyperresponsiveness, PDE4D expression and airway inflammation in a murine model of asthma.
    Deng YM, Xie QM, Tang HF, Sun JG, Deng JF, Chen JQ, Yang SY.
    Eur J Pharmacol; 2006 Oct 10; 547(1-3):125-35. PubMed ID: 16956605
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  • 11. Inhibitory effects of flavonoids on phosphodiesterase isozymes from guinea pig and their structure-activity relationships.
    Ko WC, Shih CM, Lai YH, Chen JH, Huang HL.
    Biochem Pharmacol; 2004 Nov 15; 68(10):2087-94. PubMed ID: 15476679
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  • 12. Synthesis, biological evaluation and molecular modelling studies on benzothiadiazine derivatives as PDE4 selective inhibitors.
    Tait A, Luppi A, Hatzelmann A, Fossa P, Mosti L.
    Bioorg Med Chem; 2005 Feb 15; 13(4):1393-402. PubMed ID: 15670947
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  • 13. New orally active PDE4 inhibitors with therapeutic potential.
    Ochiai H, Ishida A, Ohtani T, Kusumi K, Kishikawa K, Yamamoto S, Takeda H, Obata T, Nakai H, Toda M.
    Bioorg Med Chem; 2004 Aug 01; 12(15):4089-100. PubMed ID: 15246087
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  • 15. Imidazo[1,2-a]quinoxalines: synthesis and cyclic nucleotide phosphodiesterase inhibitory activity.
    Parra S, Laurent F, Subra G, Deleuze-Masquefa C, Benezech V, Fabreguettes J, Vidal J, Pocock T, Elliott K, Small R, Escale R, Michel A, Chapat J, Bonnet P.
    Eur J Med Chem; 2001 Mar 01; 36(3):255-64. PubMed ID: 11337104
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  • 20. PDE4B5, a novel, super-short, brain-specific cAMP phosphodiesterase-4 variant whose isoform-specifying N-terminal region is identical to that of cAMP phosphodiesterase-4D6 (PDE4D6).
    Cheung YF, Kan Z, Garrett-Engele P, Gall I, Murdoch H, Baillie GS, Camargo LM, Johnson JM, Houslay MD, Castle JC.
    J Pharmacol Exp Ther; 2007 Aug 01; 322(2):600-9. PubMed ID: 17519386
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