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Journal Abstract Search

116 related items for PubMed ID: 14980678

  • 1.
    ; . PubMed ID:
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  • 2. New fluorinated pyrrolidine and azetidine amides as dipeptidyl peptidase IV inhibitors.
    Hulin B, Cabral S, Lopaze MG, Van Volkenburg MA, Andrews KM, Parker JC.
    Bioorg Med Chem Lett; 2005 Nov 01; 15(21):4770-3. PubMed ID: 16115768
    [Abstract] [Full Text] [Related]

  • 3. Discovery of potent, selective, and orally bioavailable pyridone-based dipeptidyl peptidase-4 inhibitors.
    Xu J, Wei L, Mathvink R, Edmondson SD, Mastracchio A, Eiermann GJ, He H, Leone JF, Leiting B, Lyons KA, Marsilio F, Patel RA, Petrov A, Wu JK, Thornberry NA, Weber AE.
    Bioorg Med Chem Lett; 2006 Mar 01; 16(5):1346-9. PubMed ID: 16332437
    [Abstract] [Full Text] [Related]

  • 4. Design, synthesis, and biological evaluation of triazolopiperazine-based beta-amino amides as potent, orally active dipeptidyl peptidase IV (DPP-4) inhibitors.
    Kowalchick JE, Leiting B, Pryor KD, Marsilio F, Wu JK, He H, Lyons KA, Eiermann GJ, Petrov A, Scapin G, Patel RA, Thornberry NA, Weber AE, Kim D.
    Bioorg Med Chem Lett; 2007 Nov 01; 17(21):5934-9. PubMed ID: 17827003
    [Abstract] [Full Text] [Related]

  • 5. Substituted pyrrolidine-2,4-dicarboxylic acid amides as potent dipeptidyl peptidase IV inhibitors.
    Tsai TY, Coumar MS, Hsu T, Hsieh HP, Chien CH, Chen CT, Chang CN, Lo YK, Wu SH, Huang CY, Huang YW, Wang MH, Wu HY, Lee HJ, Chen X, Chao YS, Jiaang WT.
    Bioorg Med Chem Lett; 2006 Jun 15; 16(12):3268-72. PubMed ID: 16581245
    [Abstract] [Full Text] [Related]

  • 6. (3R,4S)-4-(2,4,5-Trifluorophenyl)-pyrrolidin-3-ylamine inhibitors of dipeptidyl peptidase IV: synthesis, in vitro, in vivo, and X-ray crystallographic characterization.
    Wright SW, Ammirati MJ, Andrews KM, Brodeur AM, Danley DE, Doran SD, Lillquist JS, Liu S, McClure LD, McPherson RK, Olson TV, Orena SJ, Parker JC, Rocke BN, Soeller WC, Soglia CB, Treadway JL, Vanvolkenburg MA, Zhao Z, Cox ED.
    Bioorg Med Chem Lett; 2007 Oct 15; 17(20):5638-42. PubMed ID: 17822893
    [Abstract] [Full Text] [Related]

  • 7. cis-2,5-dicyanopyrrolidine inhibitors of dipeptidyl peptidase IV: synthesis and in vitro, in vivo, and X-ray crystallographic characterization.
    Wright SW, Ammirati MJ, Andrews KM, Brodeur AM, Danley DE, Doran SD, Lillquist JS, McClure LD, McPherson RK, Orena SJ, Parker JC, Polivkova J, Qiu X, Soeller WC, Soglia CB, Treadway JL, VanVolkenburg MA, Wang H, Wilder DC, Olson TV.
    J Med Chem; 2006 Jun 01; 49(11):3068-76. PubMed ID: 16722626
    [Abstract] [Full Text] [Related]

  • 8.
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  • 9. Metabolic activation of fluoropyrrolidine dipeptidyl peptidase-IV inhibitors by rat liver microsomes.
    Xu S, Zhu B, Teffera Y, Pan DE, Caldwell CG, Doss G, Stearns RA, Evans DC, Beconi MG.
    Drug Metab Dispos; 2005 Jan 01; 33(1):121-30. PubMed ID: 15486074
    [Abstract] [Full Text] [Related]

  • 10. Synthesis and structure-activity relationships of potent 3- or 4-substituted-2-cyanopyrrolidine dipeptidyl peptidase IV inhibitors.
    Fukushima H, Hiratate A, Takahashi M, Saito M, Munetomo E, Kitano K, Saito H, Takaoka Y, Yamamoto K.
    Bioorg Med Chem; 2004 Dec 01; 12(23):6053-61. PubMed ID: 15519151
    [Abstract] [Full Text] [Related]

  • 11. 3-[2-((2S)-2-cyano-pyrrolidin-1-yl)-2-oxo-ethylamino]-3-methyl-butyramide analogues as selective DPP-IV inhibitors for the treatment of type-II diabetes.
    Coumar MS, Chang CN, Chen CT, Chen X, Chien CH, Tsai TY, Cheng JH, Wu HY, Han CH, Wu SH, Huang YW, Hsu T, Hsu LJ, Chao YS, Hsieh HP, Jiaang WT.
    Bioorg Med Chem Lett; 2007 Mar 01; 17(5):1274-9. PubMed ID: 17194587
    [Abstract] [Full Text] [Related]

  • 12. From lead to preclinical candidate: optimization of beta-homophenylalanine based inhibitors of dipeptidyl peptidase IV.
    Nordhoff S, López-Canet M, Hoffmann-Enger B, Bulat S, Cerezo-Gálvez S, Hill O, Rosenbaum C, Rummey C, Thiemann M, Matassa VG, Edwards PJ, Feurer A.
    Bioorg Med Chem Lett; 2009 Aug 15; 19(16):4818-23. PubMed ID: 19576767
    [Abstract] [Full Text] [Related]

  • 13. Aminomethylpyrimidines as novel DPP-IV inhibitors: a 10(5)-fold activity increase by optimization of aromatic substituents.
    Peters JU, Weber S, Kritter S, Weiss P, Wallier A, Boehringer M, Hennig M, Kuhn B, Loeffler BM.
    Bioorg Med Chem Lett; 2004 Mar 22; 14(6):1491-3. PubMed ID: 15006388
    [Abstract] [Full Text] [Related]

  • 14. 1,3-disubstituted 4-aminopiperidines as useful tools in the optimization of the 2-aminobenzo[a]quinolizine dipeptidyl peptidase IV inhibitors.
    Lübbers T, Böhringer M, Gobbi L, Hennig M, Hunziker D, Kuhn B, Löffler B, Mattei P, Narquizian R, Peters JU, Ruff Y, Wessel HP, Wyss P.
    Bioorg Med Chem Lett; 2007 Jun 01; 17(11):2966-70. PubMed ID: 17418568
    [Abstract] [Full Text] [Related]

  • 15. Rational design and synthesis of potent and long-lasting glutamic acid-based dipeptidyl peptidase IV inhibitors.
    Tsai TY, Hsu T, Chen CT, Cheng JH, Chiou MC, Huang CH, Tseng YJ, Yeh TK, Huang CY, Yeh KC, Huang YW, Wu SH, Wang MH, Chen X, Chao YS, Jiaang WT.
    Bioorg Med Chem Lett; 2009 Apr 01; 19(7):1908-12. PubMed ID: 19269819
    [Abstract] [Full Text] [Related]

  • 16. Discovery of potent and selective dipeptidyl peptidase IV inhibitors derived from beta-aminoamides bearing subsituted triazolopiperazines.
    Kim D, Kowalchick JE, Brockunier LL, Parmee ER, Eiermann GJ, Fisher MH, He H, Leiting B, Lyons K, Scapin G, Patel SB, Petrov A, Pryor KD, Roy RS, Wu JK, Zhang X, Wyvratt MJ, Zhang BB, Zhu L, Thornberry NA, Weber AE.
    J Med Chem; 2008 Feb 14; 51(3):589-602. PubMed ID: 18201067
    [Abstract] [Full Text] [Related]

  • 17. 4-arylcyclohexylalanine analogs as potent, selective, and orally active inhibitors of dipeptidyl peptidase IV.
    Kaelin DE, Smenton AL, Eiermann GJ, He H, Leiting B, Lyons KA, Patel RA, Patel SB, Petrov A, Scapin G, Wu JK, Thornberry NA, Weber AE, Duffy JL.
    Bioorg Med Chem Lett; 2007 Nov 01; 17(21):5806-11. PubMed ID: 17851076
    [Abstract] [Full Text] [Related]

  • 18. 2-Cyano-4-fluoro-1-thiovalylpyrrolidine analogues as potent inhibitors of DPP-IV.
    Haffner CD, McDougald DL, Reister SM, Thompson BD, Conlee C, Fang J, Bass J, Lenhard JM, Croom D, Secosky-Chang MB, Tomaszek T, McConn D, Wells-Knecht K, Johnson PR.
    Bioorg Med Chem Lett; 2005 Dec 01; 15(23):5257-61. PubMed ID: 16168640
    [Abstract] [Full Text] [Related]

  • 19. Discovery of an orally efficaceous 4-phenoxypyrrolidine-based BACE-1 inhibitor.
    Iserloh U, Pan J, Stamford AW, Kennedy ME, Zhang Q, Zhang L, Parker EM, McHugh NA, Favreau L, Strickland C, Voigt J.
    Bioorg Med Chem Lett; 2008 Jan 01; 18(1):418-22. PubMed ID: 17980584
    [Abstract] [Full Text] [Related]

  • 20. Substituted piperazines as novel dipeptidyl peptidase IV inhibitors.
    Brockunier LL, He J, Colwell LF, Habulihaz B, He H, Leiting B, Lyons KA, Marsilio F, Patel RA, Teffera Y, Wu JK, Thornberry NA, Weber AE, Parmee ER.
    Bioorg Med Chem Lett; 2004 Sep 20; 14(18):4763-6. PubMed ID: 15324904
    [Abstract] [Full Text] [Related]

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