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Journal Abstract Search

210 related items for PubMed ID: 14982147

  • 1. In silico predictive metabolism: a structural/electronic filter method.
    Harris DL.
    Curr Opin Drug Discov Devel; 2004 Jan; 7(1):43-8. PubMed ID: 14982147
    [Abstract] [Full Text] [Related]

  • 2. Designing better drugs: predicting cytochrome P450 metabolism.
    de Groot MJ.
    Drug Discov Today; 2006 Jul; 11(13-14):601-6. PubMed ID: 16793528
    [Abstract] [Full Text] [Related]

  • 3. Structure-based drug metabolism predictions for drug design.
    Sun H, Scott DO.
    Chem Biol Drug Des; 2010 Jan; 75(1):3-17. PubMed ID: 19878193
    [Abstract] [Full Text] [Related]

  • 4. MetaSite: understanding metabolism in human cytochromes from the perspective of the chemist.
    Cruciani G, Carosati E, De Boeck B, Ethirajulu K, Mackie C, Howe T, Vianello R.
    J Med Chem; 2005 Nov 03; 48(22):6970-9. PubMed ID: 16250655
    [Abstract] [Full Text] [Related]

  • 5. Human P450s involved in drug metabolism and the use of structural modelling for understanding substrate selectivity and binding affinity.
    Lewis DF, Ito Y.
    Xenobiotica; 2009 Aug 03; 39(8):625-35. PubMed ID: 19514836
    [Abstract] [Full Text] [Related]

  • 6. Promiscuity: what protects us, perplexes us.
    Redinbo MR.
    Drug Discov Today; 2004 May 15; 9(10):431-2. PubMed ID: 15109946
    [No Abstract] [Full Text] [Related]

  • 7. In silico toxicology for the pharmaceutical sciences.
    Valerio LG.
    Toxicol Appl Pharmacol; 2009 Dec 15; 241(3):356-70. PubMed ID: 19716836
    [Abstract] [Full Text] [Related]

  • 8. High confidence predictions of drug-drug interactions: predicting affinities for cytochrome P450 2C9 with multiple computational methods.
    Hudelson MG, Ketkar NS, Holder LB, Carlson TJ, Peng CC, Waldher BJ, Jones JP.
    J Med Chem; 2008 Feb 14; 51(3):648-54. PubMed ID: 18211009
    [Abstract] [Full Text] [Related]

  • 9. Human CYPs involved in drug metabolism: structures, substrates and binding affinities.
    Lewis DF, Ito Y.
    Expert Opin Drug Metab Toxicol; 2010 Jun 14; 6(6):661-74. PubMed ID: 20402561
    [Abstract] [Full Text] [Related]

  • 10. Predicting ADME properties and side effects: the BioPrint approach.
    Krejsa CM, Horvath D, Rogalski SL, Penzotti JE, Mao B, Barbosa F, Migeon JC.
    Curr Opin Drug Discov Devel; 2003 Jul 14; 6(4):470-80. PubMed ID: 12951810
    [Abstract] [Full Text] [Related]

  • 11. In silico human and rat Vss quantitative structure-activity relationship models.
    Gleeson MP, Waters NJ, Paine SW, Davis AM.
    J Med Chem; 2006 Mar 23; 49(6):1953-63. PubMed ID: 16539383
    [Abstract] [Full Text] [Related]

  • 12. Do Fukui function maxima relate to sites of metabolism? A critical case study.
    Beck ME.
    J Chem Inf Model; 2005 Mar 23; 45(2):273-82. PubMed ID: 15807488
    [Abstract] [Full Text] [Related]

  • 13. Building predictive ADMET models for early decisions in drug discovery.
    Penzotti JE, Landrum GA, Putta S.
    Curr Opin Drug Discov Devel; 2004 Jan 23; 7(1):49-61. PubMed ID: 14982148
    [Abstract] [Full Text] [Related]

  • 14. Clustering and its application in multi-target prediction.
    Liu W, Johnson DE.
    Curr Opin Drug Discov Devel; 2009 Jan 23; 12(1):98-107. PubMed ID: 19152218
    [Abstract] [Full Text] [Related]

  • 15. Using in vitro human tissues to predict pharmacokinetic properties.
    Huebert ND, Dasgupta M, Chen Y.
    Curr Opin Drug Discov Devel; 2004 Jan 23; 7(1):69-74. PubMed ID: 14982150
    [Abstract] [Full Text] [Related]

  • 16. Substrate selectivity of drug-metabolizing cytochrome P450s predicted from crystal structures and in silico modeling.
    Dong D, Wu B, Chow D, Hu M.
    Drug Metab Rev; 2012 May 23; 44(2):192-208. PubMed ID: 22251142
    [Abstract] [Full Text] [Related]

  • 17. Compound lipophilicity for substrate binding to human P450s in drug metabolism.
    Lewis DF, Jacobs MN, Dickins M.
    Drug Discov Today; 2004 Jun 15; 9(12):530-7. PubMed ID: 15183161
    [Abstract] [Full Text] [Related]

  • 18. Hologram QSAR model for the prediction of human oral bioavailability.
    Moda TL, Montanari CA, Andricopulo AD.
    Bioorg Med Chem; 2007 Dec 15; 15(24):7738-45. PubMed ID: 17870541
    [Abstract] [Full Text] [Related]

  • 19. The complexities inherent in attempts to decrease drug clearance by blocking sites of CYP-mediated metabolism.
    Fisher MB, Henne KR, Boer J.
    Curr Opin Drug Discov Devel; 2006 Jan 15; 9(1):101-9. PubMed ID: 16445122
    [Abstract] [Full Text] [Related]

  • 20. Prediction of drug-like molecular properties: modeling cytochrome p450 interactions.
    Jalaie M, Arimoto R, Gifford E, Schefzick S, Waller CL.
    Methods Mol Biol; 2004 Jan 15; 275():449-520. PubMed ID: 15141126
    [Abstract] [Full Text] [Related]

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