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Journal Abstract Search

165 related items for PubMed ID: 14985416

  • 1. Neuroprotective effects of a novel poly(ADP-ribose) polymerase-1 inhibitor, 2-[3-[4-(4-chlorophenyl)-1-piperazinyl] propyl]-4(3H)-quinazolinone (FR255595), in an in vitro model of cell death and in mouse 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease.
    Iwashita A, Yamazaki S, Mihara K, Hattori K, Yamamoto H, Ishida J, Matsuoka N, Mutoh S.
    J Pharmacol Exp Ther; 2004 Jun; 309(3):1067-78. PubMed ID: 14985416
    [Abstract] [Full Text] [Related]

  • 2. A novel and potent poly(ADP-ribose) polymerase-1 inhibitor, FR247304 (5-chloro-2-[3-(4-phenyl-3,6-dihydro-1(2H)-pyridinyl)propyl]-4(3H)-quinazolinone), attenuates neuronal damage in in vitro and in vivo models of cerebral ischemia.
    Iwashita A, Tojo N, Matsuura S, Yamazaki S, Kamijo K, Ishida J, Yamamoto H, Hattori K, Matsuoka N, Mutoh S.
    J Pharmacol Exp Ther; 2004 Aug; 310(2):425-36. PubMed ID: 15075382
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  • 3. A new poly(ADP-ribose) polymerase inhibitor, FR261529 [2-(4-chlorophenyl)-5-quinoxalinecarboxamide], ameliorates methamphetamine-induced dopaminergic neurotoxicity in mice.
    Iwashita A, Mihara K, Yamazaki S, Matsuura S, Ishida J, Yamamoto H, Hattori K, Matsuoka N, Mutoh S.
    J Pharmacol Exp Ther; 2004 Sep; 310(3):1114-24. PubMed ID: 15113847
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  • 4. Implication of poly (ADP-ribose) polymerase (PARP) in neurodegeneration and brain energy metabolism. Decreases in mouse brain NAD+ and ATP caused by MPTP are prevented by the PARP inhibitor benzamide.
    Cosi C, Marien M.
    Ann N Y Acad Sci; 1999 Sep; 890():227-39. PubMed ID: 10668429
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  • 5. A novel and orally active poly(ADP-ribose) polymerase inhibitor, KR-33889 [2-[methoxycarbonyl(4-methoxyphenyl) methylsulfanyl]-1H-benzimidazole-4-carboxylic acid amide], attenuates injury in in vitro model of cell death and in vivo model of cardiac ischemia.
    Oh KS, Lee S, Yi KY, Seo HW, Koo HN, Lee BH.
    J Pharmacol Exp Ther; 2009 Jan; 328(1):10-8. PubMed ID: 18836068
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  • 6. Poly(ADP-ribose)polymerase inhibitor can attenuate the neuronal death after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity in mice.
    Yokoyama H, Kuroiwa H, Tsukada T, Uchida H, Kato H, Araki T.
    J Neurosci Res; 2010 May 15; 88(7):1522-36. PubMed ID: 19998477
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  • 10. Poly(ADP-ribose) polymerase activation mediates 1-methyl-4-phenyl-1, 2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism.
    Mandir AS, Przedborski S, Jackson-Lewis V, Wang ZQ, Simbulan-Rosenthal CM, Smulson ME, Hoffman BE, Guastella DB, Dawson VL, Dawson TM.
    Proc Natl Acad Sci U S A; 1999 May 11; 96(10):5774-9. PubMed ID: 10318960
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  • 13. NAD+ as a metabolic link between DNA damage and cell death.
    Ying W, Alano CC, Garnier P, Swanson RA.
    J Neurosci Res; 1999 May 11; 79(1-2):216-23. PubMed ID: 15562437
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  • 14. Prevention of the degeneration of human dopaminergic neurons in an astrocyte co-culture system allowing endogenous drug metabolism.
    Efremova L, Schildknecht S, Adam M, Pape R, Gutbier S, Hanf B, Bürkle A, Leist M.
    Br J Pharmacol; 2015 Aug 11; 172(16):4119-32. PubMed ID: 25989025
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  • 15. Protective effects of SUN N8075, a novel agent with antioxidant properties, in in vitro and in vivo models of Parkinson's disease.
    Oyagi A, Oida Y, Hara H, Izuta H, Shimazawa M, Matsunaga N, Adachi T, Hara H.
    Brain Res; 2008 Jun 12; 1214():169-76. PubMed ID: 18457816
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  • 16. Caspase-1 Deficiency Alleviates Dopaminergic Neuronal Death via Inhibiting Caspase-7/AIF Pathway in MPTP/p Mouse Model of Parkinson's Disease.
    Qiao C, Zhang LX, Sun XY, Ding JH, Lu M, Hu G.
    Mol Neurobiol; 2017 Aug 12; 54(6):4292-4302. PubMed ID: 27339879
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  • 17. Neuroprotective effects of NU1025, a PARP inhibitor in cerebral ischemia are mediated through reduction in NAD depletion and DNA fragmentation.
    Kaundal RK, Shah KK, Sharma SS.
    Life Sci; 2006 Nov 10; 79(24):2293-302. PubMed ID: 16935310
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