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217 related items for PubMed ID: 14988218

  • 1. Stereoselective metabolism and tissue retention in rats of the individual enantiomers of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), metabolites of the tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).
    Zimmerman CL, Wu Z, Upadhyaya P, Hecht SS.
    Carcinogenesis; 2004 Jul; 25(7):1237-42. PubMed ID: 14988218
    [Abstract] [Full Text] [Related]

  • 2. Disposition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in bile duct-cannulated rats: stereoselective metabolism and tissue distribution.
    Wu Z, Upadhyaya P, Carmella SG, Hecht SS, Zimmerman CL.
    Carcinogenesis; 2002 Jan; 23(1):171-9. PubMed ID: 11756238
    [Abstract] [Full Text] [Related]

  • 3. Formation and accumulation of pyridyloxobutyl DNA adducts in F344 rats chronically treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and enantiomers of its metabolite, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol.
    Lao Y, Yu N, Kassie F, Villalta PW, Hecht SS.
    Chem Res Toxicol; 2007 Feb; 20(2):235-45. PubMed ID: 17305407
    [Abstract] [Full Text] [Related]

  • 4. Analysis of pyridyloxobutyl and pyridylhydroxybutyl DNA adducts in extrahepatic tissues of F344 rats treated chronically with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and enantiomers of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol.
    Zhang S, Wang M, Villalta PW, Lindgren BR, Upadhyaya P, Lao Y, Hecht SS.
    Chem Res Toxicol; 2009 May; 22(5):926-36. PubMed ID: 19358518
    [Abstract] [Full Text] [Related]

  • 5. Tumorigenicity and metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol enantiomers and metabolites in the A/J mouse.
    Upadhyaya P, Kenney PM, Hochalter JB, Wang M, Hecht SS.
    Carcinogenesis; 1999 Aug; 20(8):1577-82. PubMed ID: 10426810
    [Abstract] [Full Text] [Related]

  • 6. Analysis of human urine for pyridine-N-oxide metabolites of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a tobacco-specific lung carcinogen.
    Carmella SG, Borukhova A, Akerkar SA, Hecht SS.
    Cancer Epidemiol Biomarkers Prev; 1997 Feb; 6(2):113-20. PubMed ID: 9037562
    [Abstract] [Full Text] [Related]

  • 7. Biotransformation and transport of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in bile duct-cannulated wild-type and Mrp2/Abcc2-deficient (TR ) Wistar rats.
    Leslie EM, Ghibellini G, Nezasa K, Brouwer KL.
    Carcinogenesis; 2007 Dec; 28(12):2650-6. PubMed ID: 17724374
    [Abstract] [Full Text] [Related]

  • 8. Quantitation of metabolites of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone after cessation of smokeless tobacco use.
    Hecht SS, Carmella SG, Ye M, Le KA, Jensen JA, Zimmerman CL, Hatsukami DK.
    Cancer Res; 2002 Jan 01; 62(1):129-34. PubMed ID: 11782369
    [Abstract] [Full Text] [Related]

  • 9. Quantitation of pyridylhydroxybutyl-DNA adducts in liver and lung of F-344 rats treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and enantiomers of its metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol.
    Upadhyaya P, Kalscheuer S, Hochalter JB, Villalta PW, Hecht SS.
    Chem Res Toxicol; 2008 Jul 01; 21(7):1468-76. PubMed ID: 18570389
    [Abstract] [Full Text] [Related]

  • 10. Biliary excretion of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in the rat.
    Schulze J, Richter E, Binder U, Zwickenpflug W.
    Carcinogenesis; 1992 Nov 01; 13(11):1961-5. PubMed ID: 1423863
    [Abstract] [Full Text] [Related]

  • 11. Carcinogenicity and DNA adduct formation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and enantiomers of its metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in F-344 rats.
    Balbo S, Johnson CS, Kovi RC, James-Yi SA, O'Sullivan MG, Wang M, Le CT, Khariwala SS, Upadhyaya P, Hecht SS.
    Carcinogenesis; 2014 Dec 01; 35(12):2798-806. PubMed ID: 25269804
    [Abstract] [Full Text] [Related]

  • 12. Characterization of a glucuronide metabolite of 4-(methyl-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and its dose-dependent excretion in the urine of mice and rats.
    Morse MA, Eklind KI, Toussaint M, Amin SG, Chung FL.
    Carcinogenesis; 1990 Oct 01; 11(10):1819-23. PubMed ID: 2208595
    [Abstract] [Full Text] [Related]

  • 13. Pyridylhydroxybutyl and pyridyloxobutyl DNA phosphate adduct formation in rats treated chronically with enantiomers of the tobacco-specific nitrosamine metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol.
    Ma B, Zarth AT, Carlson ES, Villalta PW, Stepanov I, Hecht SS.
    Mutagenesis; 2017 Dec 31; 32(6):561-570. PubMed ID: 29186507
    [Abstract] [Full Text] [Related]

  • 14. Stereoselective metabolism of nicotine and tobacco-specific N-nitrosamines to 4-hydroxy-4-(3-pyridyl)butanoic acid in rats.
    Trushin N, Hecht SS.
    Chem Res Toxicol; 1999 Feb 31; 12(2):164-71. PubMed ID: 10027794
    [Abstract] [Full Text] [Related]

  • 15. Formation and metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol enantiomers in vitro in mouse, rat and human tissues.
    Upadhyaya P, Carmella SG, Guengerich FP, Hecht SS.
    Carcinogenesis; 2000 Jun 31; 21(6):1233-8. PubMed ID: 10837015
    [Abstract] [Full Text] [Related]

  • 16. Quantitation of urinary metabolites of a tobacco-specific lung carcinogen after smoking cessation.
    Hecht SS, Carmella SG, Chen M, Dor Koch JF, Miller AT, Murphy SE, Jensen JA, Zimmerman CL, Hatsukami DK.
    Cancer Res; 1999 Feb 01; 59(3):590-6. PubMed ID: 9973205
    [Abstract] [Full Text] [Related]

  • 17. Uptake and metabolism of carcinogenic levels of tobacco-specific nitrosamines by Sudanese snuff dippers.
    Murphy SE, Carmella SG, Idris AM, Hoffmann D.
    Cancer Epidemiol Biomarkers Prev; 1994 Feb 01; 3(5):423-8. PubMed ID: 7920210
    [Abstract] [Full Text] [Related]

  • 18. The profile of urinary metabolites of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in rats is determined by its pulmonary metabolism.
    Schneider T, Frei E, Wiessler M.
    Chem Biol Interact; 1999 Apr 15; 118(3):247-66. PubMed ID: 10362230
    [Abstract] [Full Text] [Related]

  • 19. Methyl DNA Phosphate Adduct Formation in Rats Treated Chronically with 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone and Enantiomers of Its Metabolite 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol.
    Ma B, Zarth AT, Carlson ES, Villalta PW, Upadhyaya P, Stepanov I, Hecht SS.
    Chem Res Toxicol; 2018 Jan 16; 31(1):48-57. PubMed ID: 29131934
    [Abstract] [Full Text] [Related]

  • 20. Metabolism of a glucuronide conjugate of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in rats.
    Atawodi SE, Michelsen K, Richter E.
    Arch Toxicol; 1994 Jan 16; 69(1):14-7. PubMed ID: 7717849
    [Abstract] [Full Text] [Related]

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