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704 related items for PubMed ID: 14993145

  • 1. Unique, highly proliferative growth phenotype expressed by embryonic and neointimal smooth muscle cells is driven by constitutive Akt, mTOR, and p70S6K signaling and is actively repressed by PTEN.
    Mourani PM, Garl PJ, Wenzlau JM, Carpenter TC, Stenmark KR, Weiser-Evans MC.
    Circulation; 2004 Mar 16; 109(10):1299-306. PubMed ID: 14993145
    [Abstract] [Full Text] [Related]

  • 2. Perlecan-induced suppression of smooth muscle cell proliferation is mediated through increased activity of the tumor suppressor PTEN.
    Garl PJ, Wenzlau JM, Walker HA, Whitelock JM, Costell M, Weiser-Evans MC.
    Circ Res; 2004 Feb 06; 94(2):175-83. PubMed ID: 14656929
    [Abstract] [Full Text] [Related]

  • 3. Endothelial cell activation of the smooth muscle cell phosphoinositide 3-kinase/Akt pathway promotes differentiation.
    Brown DJ, Rzucidlo EM, Merenick BL, Wagner RJ, Martin KA, Powell RJ.
    J Vasc Surg; 2005 Mar 06; 41(3):509-16. PubMed ID: 15838487
    [Abstract] [Full Text] [Related]

  • 4. mTOR regulates vascular smooth muscle cell differentiation from human bone marrow-derived mesenchymal progenitors.
    Hegner B, Lange M, Kusch A, Essin K, Sezer O, Schulze-Lohoff E, Luft FC, Gollasch M, Dragun D.
    Arterioscler Thromb Vasc Biol; 2009 Feb 06; 29(2):232-8. PubMed ID: 19074484
    [Abstract] [Full Text] [Related]

  • 5. Glucose-potentiated chemotaxis in human vascular smooth muscle is dependent on cross-talk between the PI3K and MAPK signaling pathways.
    Campbell M, Allen WE, Sawyer C, Vanhaesebroeck B, Trimble ER.
    Circ Res; 2004 Aug 20; 95(4):380-8. PubMed ID: 15242975
    [Abstract] [Full Text] [Related]

  • 6. Transient reexpression of an embryonic autonomous growth phenotype by adult carotid artery smooth muscle cells after vascular injury.
    Weiser-Evans MC, Quinn BE, Burkard MR, Stenmark KR.
    J Cell Physiol; 2000 Jan 20; 182(1):12-23. PubMed ID: 10567912
    [Abstract] [Full Text] [Related]

  • 7. Suppression of c-Cbl tyrosine phosphorylation inhibits neointimal formation in balloon-injured rat arteries.
    Tang Z, Wang Y, Fan Y, Zhu Y, Chien S, Wang N.
    Circulation; 2008 Aug 12; 118(7):764-72. PubMed ID: 18663086
    [Abstract] [Full Text] [Related]

  • 8. Interferon-gamma induces human vascular smooth muscle cell proliferation and intimal expansion by phosphatidylinositol 3-kinase dependent mammalian target of rapamycin raptor complex 1 activation.
    Wang Y, Bai Y, Qin L, Zhang P, Yi T, Teesdale SA, Zhao L, Pober JS, Tellides G.
    Circ Res; 2007 Sep 14; 101(6):560-9. PubMed ID: 17656678
    [Abstract] [Full Text] [Related]

  • 9. Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics.
    Zhong H, Chiles K, Feldser D, Laughner E, Hanrahan C, Georgescu MM, Simons JW, Semenza GL.
    Cancer Res; 2000 Mar 15; 60(6):1541-5. PubMed ID: 10749120
    [Abstract] [Full Text] [Related]

  • 10. Caveolin-1 facilitates mechanosensitive protein kinase B (Akt) signaling in vitro and in vivo.
    Sedding DG, Hermsen J, Seay U, Eickelberg O, Kummer W, Schwencke C, Strasser RH, Tillmanns H, Braun-Dullaeus RC.
    Circ Res; 2005 Apr 01; 96(6):635-42. PubMed ID: 15731459
    [Abstract] [Full Text] [Related]

  • 11. Prolactin activates mammalian target-of-rapamycin through phosphatidylinositol 3-kinase and stimulates phosphorylation of p70S6K and 4E-binding protein-1 in lymphoma cells.
    Bishop JD, Nien WL, Dauphinee SM, Too CK.
    J Endocrinol; 2006 Aug 01; 190(2):307-12. PubMed ID: 16899564
    [Abstract] [Full Text] [Related]

  • 12. Longitudinal inhibition of PI3K/Akt/mTOR signaling by LY294002 and rapamycin induces growth arrest of adult T-cell leukemia cells.
    Ikezoe T, Nishioka C, Bandobashi K, Yang Y, Kuwayama Y, Adachi Y, Takeuchi T, Koeffler HP, Taguchi H.
    Leuk Res; 2007 May 01; 31(5):673-82. PubMed ID: 17007924
    [Abstract] [Full Text] [Related]

  • 13. Serotonin-induced growth of pulmonary artery smooth muscle requires activation of phosphatidylinositol 3-kinase/serine-threonine protein kinase B/mammalian target of rapamycin/p70 ribosomal S6 kinase 1.
    Liu Y, Fanburg BL.
    Am J Respir Cell Mol Biol; 2006 Feb 01; 34(2):182-91. PubMed ID: 16195541
    [Abstract] [Full Text] [Related]

  • 14. Role of the phosphatidylinositol 3-kinase/Akt and mTOR/P70S6-kinase pathways in the proliferation and apoptosis in multiple myeloma.
    Pene F, Claessens YE, Muller O, Viguié F, Mayeux P, Dreyfus F, Lacombe C, Bouscary D.
    Oncogene; 2002 Sep 26; 21(43):6587-97. PubMed ID: 12242656
    [Abstract] [Full Text] [Related]

  • 15. Type 1 insulin-like growth factor regulates MT1-MMP synthesis and tumor invasion via PI 3-kinase/Akt signaling.
    Zhang D, Brodt P.
    Oncogene; 2003 Feb 20; 22(7):974-82. PubMed ID: 12592384
    [Abstract] [Full Text] [Related]

  • 16. CREG promotes a mature smooth muscle cell phenotype and reduces neointimal formation in balloon-injured rat carotid artery.
    Han Y, Deng J, Guo L, Yan C, Liang M, Kang J, Liu H, Graham AM, Li S.
    Cardiovasc Res; 2008 Jun 01; 78(3):597-604. PubMed ID: 18267954
    [Abstract] [Full Text] [Related]

  • 17. Inactivation of the tumour suppressor, PTEN, in smooth muscle promotes a pro-inflammatory phenotype and enhances neointima formation.
    Furgeson SB, Simpson PA, Park I, Vanputten V, Horita H, Kontos CD, Nemenoff RA, Weiser-Evans MC.
    Cardiovasc Res; 2010 May 01; 86(2):274-82. PubMed ID: 20051384
    [Abstract] [Full Text] [Related]

  • 18. Regulation of the phosphatidylinositol 3-kinase, Akt/protein kinase B, FRAP/mammalian target of rapamycin, and ribosomal S6 kinase 1 signaling pathways by thyroid-stimulating hormone (TSH) and stimulating type TSH receptor antibodies in the thyroid gland.
    Suh JM, Song JH, Kim DW, Kim H, Chung HK, Hwang JH, Kim JM, Hwang ES, Chung J, Han JH, Cho BY, Ro HK, Shong M.
    J Biol Chem; 2003 Jun 13; 278(24):21960-71. PubMed ID: 12668683
    [Abstract] [Full Text] [Related]

  • 19. Targeted deletion of PTEN in smooth muscle cells results in vascular remodeling and recruitment of progenitor cells through induction of stromal cell-derived factor-1alpha.
    Nemenoff RA, Simpson PA, Furgeson SB, Kaplan-Albuquerque N, Crossno J, Garl PJ, Cooper J, Weiser-Evans MC.
    Circ Res; 2008 May 09; 102(9):1036-45. PubMed ID: 18340011
    [Abstract] [Full Text] [Related]

  • 20. Rapamycin promotes vascular smooth muscle cell differentiation through insulin receptor substrate-1/phosphatidylinositol 3-kinase/Akt2 feedback signaling.
    Martin KA, Merenick BL, Ding M, Fetalvero KM, Rzucidlo EM, Kozul CD, Brown DJ, Chiu HY, Shyu M, Drapeau BL, Wagner RJ, Powell RJ.
    J Biol Chem; 2007 Dec 07; 282(49):36112-20. PubMed ID: 17908691
    [Abstract] [Full Text] [Related]

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