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Journal Abstract Search

131 related items for PubMed ID: 15006400

  • 1. A novel approach to the synthesis of cytotoxic C2-C3 unsaturated pyrrolo[2,1-c]benzodiazepines (PBDs) with conjugated acrylyl C2-substituents.
    Chen Z, Gregson SJ, Howard PW, Thurston DE.
    Bioorg Med Chem Lett; 2004 Mar 22; 14(6):1547-9. PubMed ID: 15006400
    [Abstract] [Full Text] [Related]

  • 2. Application of the Stille coupling reaction to the synthesis of C2-substituted endo-exo unsaturated pyrrolo[2,1-c][1,4]benzodiazepines (PBDs).
    Tiberghien AC, Hagan D, Howard PW, Thurston DE.
    Bioorg Med Chem Lett; 2004 Oct 18; 14(20):5041-4. PubMed ID: 15380195
    [Abstract] [Full Text] [Related]

  • 3. Synthesis and DNA binding affinity of novel A-C8/C-C2-exo unsaturated alkoxyamido-linked pyrrolo[2,1-c][1,4]benzodiazepine dimers.
    Kamal A, Srinivas O, Ramulu P, Ramesh G, Kumar PP, Kumar MS.
    Bioorg Med Chem; 2004 Aug 15; 12(16):4337-50. PubMed ID: 15265486
    [Abstract] [Full Text] [Related]

  • 4. Linker length modulates DNA cross-linking reactivity and cytotoxic potency of C8/C8' ether-linked C2-exo-unsaturated pyrrolo[2,1-c][1,4]benzodiazepine (PBD) dimers.
    Gregson SJ, Howard PW, Gullick DR, Hamaguchi A, Corcoran KE, Brooks NA, Hartley JA, Jenkins TC, Patel S, Guille MJ, Thurston DE.
    J Med Chem; 2004 Feb 26; 47(5):1161-74. PubMed ID: 14971896
    [Abstract] [Full Text] [Related]

  • 5. Phosphonate-linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates: synthesis, DNA-binding affinity and cytotoxicity.
    Kamal A, Kumar PP, Seshadri BN, Srinivas O, Kumar MS, Sen S, Kurian N, Juvekar AS, Zingde SM.
    Bioorg Med Chem; 2008 Apr 01; 16(7):3895-906. PubMed ID: 18262426
    [Abstract] [Full Text] [Related]

  • 6. Synthesis of new benzimidazole linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates with efficient DNA-binding affinity and potent cytotoxicity.
    Kamal A, Kumar PP, Sreekanth K, Seshadri BN, Ramulu P.
    Bioorg Med Chem Lett; 2008 Apr 15; 18(8):2594-8. PubMed ID: 18378445
    [Abstract] [Full Text] [Related]

  • 7. Effect of A-ring modifications on the DNA-binding behavior and cytotoxicity of pyrrolo[2,1-c][1,4]benzodiazepines.
    Thurston DE, Bose DS, Howard PW, Jenkins TC, Leoni A, Baraldi PG, Guiotto A, Cacciari B, Kelland LR, Foloppe MP, Rault S.
    J Med Chem; 1999 Jun 03; 42(11):1951-64. PubMed ID: 10354403
    [Abstract] [Full Text] [Related]

  • 8. Synthesis of a novel C2-aryl pyrrolo[2,1-c][1,4]benzodiazepine-5,11-dione library: effect of C2-aryl substitution on cytotoxicity and non-covalent DNA binding.
    Antonow D, Jenkins TC, Howard PW, Thurston DE.
    Bioorg Med Chem; 2007 Apr 15; 15(8):3041-53. PubMed ID: 17317191
    [Abstract] [Full Text] [Related]

  • 9. Synthesis and antitumor cytotoxicity evaluation of novel pyrrolo[2,1-c][1,4]benzodiazepine imidazole containing polyamide conjugates.
    Kumar R, Lown JW.
    Oncol Res; 2003 Apr 15; 13(4):221-33. PubMed ID: 12659423
    [Abstract] [Full Text] [Related]

  • 10. Design, synthesis and in vitro cytotoxicity studies of novel pyrrolo[2,1-c][1,4]benzodiazepine (PBD)--polymade conjugates and 2,2'-PBD dimers.
    Reddy BS, Damayanthi Y, Reddy BS, Lown JW.
    Anticancer Drug Des; 2000 Jun 15; 15(3):225-38. PubMed ID: 11049090
    [Abstract] [Full Text] [Related]

  • 11. Structure-activity relationships of monomeric C2-aryl pyrrolo[2,1-c][1,4]benzodiazepine (PBD) antitumor agents.
    Antonow D, Kaliszczak M, Kang GD, Coffils M, Tiberghien AC, Cooper N, Barata T, Heidelberger S, James CH, Zloh M, Jenkins TC, Reszka AP, Neidle S, Guichard SM, Jodrell DI, Hartley JA, Howard PW, Thurston DE.
    J Med Chem; 2010 Apr 08; 53(7):2927-41. PubMed ID: 20218628
    [Abstract] [Full Text] [Related]

  • 12. Synthesis of the first example of a C2-C3/C2'-C3'-endo unsaturated pyrrolo[2,1-c][1,4]benzodiazepine dimer.
    Gregson SJ, Howard PW, Corcoran KE, Jenkins TC, Kelland LR, Thurston DE.
    Bioorg Med Chem Lett; 2001 Nov 05; 11(21):2859-62. PubMed ID: 11597416
    [Abstract] [Full Text] [Related]

  • 13. [Research on agents with antineoplastic activity. LXIII. Anthramycin and analogous compounds. X. Synthesis of 11-phenyl-5H-pyrrolo[2,1-c] [1,4] benzodiazepine derivatives].
    Porretta GC, Scicchitano G, Filacchioni G, Scalzo M, Artico M.
    Farmaco Sci; 1979 Oct 05; 34(10):914-22. PubMed ID: 510534
    [Abstract] [Full Text] [Related]

  • 14. Synthesis and biological evaluation of pyrrolo[2,1-c][1,4]benzodiazepine (PBD) C8 cyclic amine conjugates.
    Masterson LA, Croker SJ, Jenkins TC, Howard PW, Thurston DE.
    Bioorg Med Chem Lett; 2004 Feb 23; 14(4):901-4. PubMed ID: 15012990
    [Abstract] [Full Text] [Related]

  • 15. Effect of C2/C3-endo unsaturation on the cytotoxicity and DNA-binding reactivity of pyrrolo[2,1-c][1,4]benzodiazepines.
    Gregson SJ, Howard PW, Barcella S, Nakamya A, Jenkins TC, Kelland LR, Thurston DE.
    Bioorg Med Chem Lett; 2000 Aug 21; 10(16):1849-51. PubMed ID: 10969983
    [Abstract] [Full Text] [Related]

  • 16. Pyrrolo[2,1-c][1,4]benzodiazepine-anthraquinone conjugates. Synthesis, DNA binding and cytotoxicity.
    Kamal A, Ramu R, Khanna GB, Saxena AK, Shanmugavel M, Pandita RM.
    Bioorg Med Chem Lett; 2004 Oct 04; 14(19):4907-9. PubMed ID: 15341949
    [Abstract] [Full Text] [Related]

  • 17. Synthesis and biological evaluation of novel pyrrolo[2,1-c][1,4]benzodiazepine prodrugs for use in antibody-directed enzyme prodrug therapy.
    Masterson LA, Spanswick VJ, Hartley JA, Begent RH, Howard PW, Thurston DE.
    Bioorg Med Chem Lett; 2006 Jan 15; 16(2):252-6. PubMed ID: 16290933
    [Abstract] [Full Text] [Related]

  • 18. Synthesis of novel C7-aryl substituted pyrrolo[2,1-c][1,4]benzodiazepines (PBDs) via pro-N10-Troc protection and Suzuki coupling.
    Guiotto A, Howard PW, Baraldi PG, Thurston DE.
    Bioorg Med Chem Lett; 1998 Nov 03; 8(21):3017-8. PubMed ID: 9873667
    [Abstract] [Full Text] [Related]

  • 19. Synthesis of DNA-interactive pyrrolo[2,1-c][1,4]benzodiazepines (PBDs).
    Antonow D, Thurston DE.
    Chem Rev; 2011 Apr 13; 111(4):2815-64. PubMed ID: 21166464
    [No Abstract] [Full Text] [Related]

  • 20. Recent developments in novel pyrrolo[2,1-c][1,4]benzodiazepine conjugates: synthesis and biological evaluation.
    Kumar R, Lown JW.
    Mini Rev Med Chem; 2003 Jun 13; 3(4):323-39. PubMed ID: 12678826
    [Abstract] [Full Text] [Related]

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