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Journal Abstract Search

151 related items for PubMed ID: 1501226

  • 1. Synthesis and antifolate evaluation of 10-ethyl-5-methyl-5,10- dideazaaminopterin and an alternative synthesis of 10-ethyl-10- deazaaminopterin (edatrexate).
    Piper JR, Johnson CA, Otter GM, Sirotnak FM.
    J Med Chem; 1992 Aug 07; 35(16):3002-6. PubMed ID: 1501226
    [Abstract] [Full Text] [Related]

  • 2. Synthesis and antifolate activity of 5-methyl-5,10-dideaza analogues of aminopterin and folic acid and an alternative synthesis of 5,10-dideazatetrahydrofolic acid, a potent inhibitor of glycinamide ribonucleotide formyltransferase.
    Piper JR, McCaleb GS, Montgomery JA, Kisliuk RL, Gaumont Y, Thorndike J, Sirotnak FM.
    J Med Chem; 1988 Nov 07; 31(11):2164-9. PubMed ID: 3184124
    [Abstract] [Full Text] [Related]

  • 3. Analogues of 10-deazaaminopterin and 5-alkyl-5,10-dideazaaminopterin with the 4-substituted 1-naphthoyl group in the place of 4-substituted benzoyl.
    Piper JR, Ramamurthy B, Johnson CA, Otter GM, Sirotnak FM.
    J Med Chem; 1996 Jan 19; 39(2):614-8. PubMed ID: 8558535
    [Abstract] [Full Text] [Related]

  • 4. Synthesis and antifolate evaluation of the 10-propargyl derivatives of 5-deazafolic acid, 5-deazaaminopterin, and 5-methyl-5-deazaaminopterin.
    Piper JR, Malik ND, Rhee MS, Galivan J, Sirotnak FM.
    J Med Chem; 1992 Jan 24; 35(2):332-7. PubMed ID: 1732551
    [Abstract] [Full Text] [Related]

  • 5. Syntheses and antifolate activity of 5-methyl-5-deaza analogues of aminopterin, methotrexate, folic acid, and N10-methylfolic acid.
    Piper JR, McCaleb GS, Montgomery JA, Kisliuk RL, Gaumont Y, Sirotnak FM.
    J Med Chem; 1986 Jun 24; 29(6):1080-7. PubMed ID: 2423690
    [Abstract] [Full Text] [Related]

  • 6. Synthesis and antifolate properties of 9-alkyl-10-deazaminopterins.
    DeGraw JI, Christie PH, Kisliuk RL, Gaumont Y, Sirotnak FM.
    J Med Chem; 1990 Jan 24; 33(1):212-5. PubMed ID: 2296020
    [Abstract] [Full Text] [Related]

  • 7. Synthesis and antifolate properties of 5,10-ethano-5,10-dideazaaminopterin.
    DeGraw JI, Christie PH, Colwell WT, Sirotnak FM.
    J Med Chem; 1992 Jan 24; 35(2):320-4. PubMed ID: 1732549
    [Abstract] [Full Text] [Related]

  • 8. Synthesis and antifolate properties of 10-alkyl-8,10-dideazaminopterins.
    DeGraw JI, Christie PH, Brown EG, Kelly LF, Kisliuk RL, Gaumont Y, Sirotnak FM.
    J Med Chem; 1984 Mar 24; 27(3):376-80. PubMed ID: 6699882
    [Abstract] [Full Text] [Related]

  • 9. Analogues of methotrexate in rheumatoid arthritis. 2. Effects of 5-deazaaminopterin, 5,10-dideazaaminopterin, and analogues on type II collagen-induced arthritis in mice.
    Piper JR, DeGraw JI, Colwell WT, Johnson CA, Smith RL, Waud WR, Sirotnak FM.
    J Med Chem; 1997 Jan 31; 40(3):377-84. PubMed ID: 9022805
    [Abstract] [Full Text] [Related]

  • 10. Synthesis and antitumor activity of 10-propargyl-10-deazaaminopterin.
    DeGraw JI, Colwell WT, Piper JR, Sirotnak FM.
    J Med Chem; 1993 Jul 23; 36(15):2228-31. PubMed ID: 8340923
    [Abstract] [Full Text] [Related]

  • 11. Synthesis and antifolate properties of 10-alkyl-5,10-dideaza analogues of methotrexate and tetrahydrofolic acid.
    DeGraw JI, Christie PH, Kisliuk RL, Gaumont Y, Sirotnak FM.
    J Med Chem; 1990 Feb 23; 33(2):673-7. PubMed ID: 2299633
    [Abstract] [Full Text] [Related]

  • 12. Methotrexate analogues. 31. Meta and ortho isomers of aminopterin, compounds with a double bond in the side chain, and a novel analogue modified at the alpha-carbon: chemical and in vitro biological studies.
    Rosowsky A, Bader H, Forsch RA, Moran RG, Freisheim JH.
    J Med Chem; 1988 Apr 23; 31(4):763-8. PubMed ID: 3351853
    [Abstract] [Full Text] [Related]

  • 13. Synthesis and biological activity of resolved C-10 diastereomers of 10-methyl- and 10-ethyl-10-deazaminopterin.
    DeGraw JI, Christie PH, Tagawa H, Kisliuk RL, Gaumont Y, Schmid FA, Sirotnak FM.
    J Med Chem; 1986 Jun 23; 29(6):1056-61. PubMed ID: 3712374
    [Abstract] [Full Text] [Related]

  • 14. Methotrexate analogues. 26. Inhibition of dihydrofolate reductase and folylpolyglutamate synthetase activity and in vitro tumor cell growth by methotrexate and aminopterin analogues containing a basic amino acid side chain.
    Rosowsky A, Freisheim JH, Moran RG, Solan VC, Bader H, Wright JE, Radike-Smith M.
    J Med Chem; 1986 May 23; 29(5):655-60. PubMed ID: 2871191
    [Abstract] [Full Text] [Related]

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  • 16. 10-Propargylaminopterin and alkyl homologues of methotrexate as inhibitors of folate metabolism.
    Piper JR, McCaleb GS, Montgomery JA, Kisliuk RL, Gaumont Y, Sirotnak FM.
    J Med Chem; 1982 Jul 23; 25(7):877-80. PubMed ID: 7108907
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  • 19. Synthesis and in vitro biological activity of new deaza analogues of folic acid, aminopterin, and methotrexate with an L-ornithine side chain.
    Rosowsky A, Forsch RA, Bader H, Freisheim JH.
    J Med Chem; 1991 Apr 23; 34(4):1447-54. PubMed ID: 2016722
    [Abstract] [Full Text] [Related]

  • 20. Convenient synthesis of 10-deazaaminopterin via a pteridine ylide.
    Piper JR, Montgomery JA.
    J Med Chem; 1980 Mar 23; 23(3):320-1. PubMed ID: 7365749
    [Abstract] [Full Text] [Related]

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