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230 related items for PubMed ID: 15023530

  • 1. Immortalization in a normal foreskin fibroblast culture following transduction of cyclin A2 or cdk1 genes in retroviral vectors.
    Luo P, Tresini M, Cristofalo V, Chen X, Saulewicz A, Gray MD, Banker DE, Klingelhutz AL, Ohtsubo M, Takihara Y, Norwood TH.
    Exp Cell Res; 2004 Apr 01; 294(2):406-19. PubMed ID: 15023530
    [Abstract] [Full Text] [Related]

  • 2. Sequential extension of proliferative lifespan in human fibroblasts induced by over-expression of CDK4 or 6 and loss of p53 function.
    Morris M, Hepburn P, Wynford-Thomas D.
    Oncogene; 2002 Jun 20; 21(27):4277-88. PubMed ID: 12082615
    [Abstract] [Full Text] [Related]

  • 3. Alterations in the p16(INK4a) and p53 tumor suppressor genes of hTERT-immortalized human fibroblasts.
    Noble JR, Zhong ZH, Neumann AA, Melki JR, Clark SJ, Reddel RR.
    Oncogene; 2004 Apr 15; 23(17):3116-21. PubMed ID: 14743210
    [Abstract] [Full Text] [Related]

  • 4. Prolonged culture of telomerase-immortalized human fibroblasts leads to a premalignant phenotype.
    Milyavsky M, Shats I, Erez N, Tang X, Senderovich S, Meerson A, Tabach Y, Goldfinger N, Ginsberg D, Harris CC, Rotter V.
    Cancer Res; 2003 Nov 01; 63(21):7147-57. PubMed ID: 14612508
    [Abstract] [Full Text] [Related]

  • 5. Reduction in mortalin level by its antisense expression causes senescence-like growth arrest in human immortalized cells.
    Wadhwa R, Takano S, Taira K, Kaul SC.
    J Gene Med; 2004 Apr 01; 6(4):439-44. PubMed ID: 15079818
    [Abstract] [Full Text] [Related]

  • 6. Replicative senescence of normal human oral keratinocytes is associated with the loss of telomerase activity without shortening of telomeres.
    Kang MK, Guo W, Park NH.
    Cell Growth Differ; 1998 Jan 01; 9(1):85-95. PubMed ID: 9438392
    [Abstract] [Full Text] [Related]

  • 7. Regulation by ionizing radiation of CDC2, cyclin A, cyclin B, thymidine kinase, topoisomerase IIalpha, and RAD51 expression in normal human diploid fibroblasts is dependent on p53/p21Waf1.
    de Toledo SM, Azzam EI, Keng P, Laffrenier S, Little JB.
    Cell Growth Differ; 1998 Nov 01; 9(11):887-96. PubMed ID: 9831241
    [Abstract] [Full Text] [Related]

  • 8. Mass cultured human fibroblasts overexpressing hTERT encounter a growth crisis following an extended period of proliferation.
    MacKenzie KL, Franco S, May C, Sadelain M, Moore MA.
    Exp Cell Res; 2000 Sep 15; 259(2):336-50. PubMed ID: 10964501
    [Abstract] [Full Text] [Related]

  • 9. Murine fibroblasts lacking p21 undergo senescence and are resistant to transformation by oncogenic Ras.
    Pantoja C, Serrano M.
    Oncogene; 1999 Sep 02; 18(35):4974-82. PubMed ID: 10490832
    [Abstract] [Full Text] [Related]

  • 10. Single-cell analysis of p16(INK4a) and p21(WAF1) expression suggests distinct mechanisms of senescence in normal human and Li-Fraumeni Syndrome fibroblasts.
    Mirzayans R, Andrais B, Scott A, Paterson MC, Murray D.
    J Cell Physiol; 2010 Apr 02; 223(1):57-67. PubMed ID: 20039273
    [Abstract] [Full Text] [Related]

  • 11. p16/pRb pathway alterations are required for bypassing senescence in human prostate epithelial cells.
    Jarrard DF, Sarkar S, Shi Y, Yeager TR, Magrane G, Kinoshita H, Nassif N, Meisner L, Newton MA, Waldman FM, Reznikoff CA.
    Cancer Res; 1999 Jun 15; 59(12):2957-64. PubMed ID: 10383161
    [Abstract] [Full Text] [Related]

  • 12. Telomere-driven karyotypic complexity concurs with p16INK4a inactivation in TP53-competent immortal endothelial cells.
    Wen VW, Wu K, Baksh S, Hinshelwood RA, Lock RB, Clark SJ, Moore MA, Mackenzie KL.
    Cancer Res; 2006 Nov 15; 66(22):10691-700. PubMed ID: 17108106
    [Abstract] [Full Text] [Related]

  • 13. Histone deacetylase inhibitors induce a senescence-like state in human cells by a p16-dependent mechanism that is independent of a mitotic clock.
    Munro J, Barr NI, Ireland H, Morrison V, Parkinson EK.
    Exp Cell Res; 2004 May 01; 295(2):525-38. PubMed ID: 15093749
    [Abstract] [Full Text] [Related]

  • 14. A methylation profile of in vitro immortalized human cell lines.
    Liu L, Zhang J, Bates S, Li JJ, Peehl DM, Rhim JS, Pfeifer GP.
    Int J Oncol; 2005 Jan 01; 26(1):275-85. PubMed ID: 15586250
    [Abstract] [Full Text] [Related]

  • 15. CDK2 translational down-regulation during endothelial senescence.
    Freedman DA, Folkman J.
    Exp Cell Res; 2005 Jul 01; 307(1):118-30. PubMed ID: 15922732
    [Abstract] [Full Text] [Related]

  • 16. Telomerase-immortalized human fibroblasts retain UV-induced mutagenesis and p53-mediated DNA damage responses.
    Porter PC, Clark DR, McDaniel LD, McGregor WG, States JC.
    DNA Repair (Amst); 2006 Jan 05; 5(1):61-70. PubMed ID: 16140041
    [Abstract] [Full Text] [Related]

  • 17. Stepwise neoplastic transformation of a telomerase immortalized fibroblast cell line.
    Zongaro S, de Stanchina E, Colombo T, D'Incalci M, Giulotto E, Mondello C.
    Cancer Res; 2005 Dec 15; 65(24):11411-8. PubMed ID: 16357149
    [Abstract] [Full Text] [Related]

  • 18. Telomerase induces immortalization of human esophageal keratinocytes without p16INK4a inactivation.
    Harada H, Nakagawa H, Oyama K, Takaoka M, Andl CD, Jacobmeier B, von Werder A, Enders GH, Opitz OG, Rustgi AK.
    Mol Cancer Res; 2003 Aug 15; 1(10):729-38. PubMed ID: 12939398
    [Abstract] [Full Text] [Related]

  • 19. Knockdown of p53 combined with expression of the catalytic subunit of telomerase is sufficient to immortalize primary human ovarian surface epithelial cells.
    Yang G, Rosen DG, Mercado-Uribe I, Colacino JA, Mills GB, Bast RC, Zhou C, Liu J.
    Carcinogenesis; 2007 Jan 15; 28(1):174-82. PubMed ID: 16829690
    [Abstract] [Full Text] [Related]

  • 20. Expression profiles of p53-, p16(INK4a)-, and telomere-regulating genes in replicative senescent primary human, mouse, and chicken fibroblast cells.
    Kim H, You S, Farris J, Kong BW, Christman SA, Foster LK, Foster DN.
    Exp Cell Res; 2002 Jan 15; 272(2):199-208. PubMed ID: 11777345
    [Abstract] [Full Text] [Related]

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