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Journal Abstract Search

163 related items for PubMed ID: 15027862

  • 1. Discovery of potent inhibitors of dihydroneopterin aldolase using CrystaLEAD high-throughput X-ray crystallographic screening and structure-directed lead optimization.
    Sanders WJ, Nienaber VL, Lerner CG, McCall JO, Merrick SM, Swanson SJ, Harlan JE, Stoll VS, Stamper GF, Betz SF, Condroski KR, Meadows RP, Severin JM, Walter KA, Magdalinos P, Jakob CG, Wagner R, Beutel BA.
    J Med Chem; 2004 Mar 25; 47(7):1709-18. PubMed ID: 15027862
    [Abstract] [Full Text] [Related]

  • 2. Crystal structure of dihydroneopterin aldolase from Mycobacterium tuberculosis associated with 8-mercaptoguanine, and development of novel S8-functionalized analogues as inhibitors: Synthesis, enzyme inhibition, in vitro toxicity and antitubercular activity.
    Czeczot AM, Muniz MN, Perelló MA, Silva ÉED, Timmers LFSM, Berger A, Gonzalez LC, Arraché Gonçalves G, Moura S, Machado P, Bizarro CV, Basso LA.
    J Enzyme Inhib Med Chem; 2024 Dec 25; 39(1):2388207. PubMed ID: 39140692
    [Abstract] [Full Text] [Related]

  • 3. Crystallographic study of inhibitors of tRNA-guanine transglycosylase suggests a new structure-based pharmacophore for virtual screening.
    Brenk R, Meyer EA, Reuter K, Stubbs MT, Garcia GA, Diederich F, Klebe G.
    J Mol Biol; 2004 Apr 16; 338(1):55-75. PubMed ID: 15050823
    [Abstract] [Full Text] [Related]

  • 4. Virtual screening for submicromolar leads of tRNA-guanine transglycosylase based on a new unexpected binding mode detected by crystal structure analysis.
    Brenk R, Naerum L, Grädler U, Gerber HD, Garcia GA, Reuter K, Stubbs MT, Klebe G.
    J Med Chem; 2003 Mar 27; 46(7):1133-43. PubMed ID: 12646024
    [Abstract] [Full Text] [Related]

  • 5. Discovery and initial SAR of arylsulfonylpiperazine inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1).
    Sun D, Wang Z, Di Y, Jaen JC, Labelle M, Ma J, Miao S, Sudom A, Tang L, Tomooka CS, Tu H, Ursu S, Walker N, Yan X, Ye Q, Powers JP.
    Bioorg Med Chem Lett; 2008 Jun 15; 18(12):3513-6. PubMed ID: 18511278
    [Abstract] [Full Text] [Related]

  • 6. Structure-based design and subsequent optimization of 2-tolyl-(1,2,3-triazol-1-yl-4-carboxamide) inhibitors of p38 MAP kinase.
    Cogan DA, Aungst R, Breinlinger EC, Fadra T, Goldberg DR, Hao MH, Kroe R, Moss N, Pargellis C, Qian KC, Swinamer AD.
    Bioorg Med Chem Lett; 2008 Jun 01; 18(11):3251-5. PubMed ID: 18462940
    [Abstract] [Full Text] [Related]

  • 7. Discovering novel ligands for macromolecules using X-ray crystallographic screening.
    Nienaber VL, Richardson PL, Klighofer V, Bouska JJ, Giranda VL, Greer J.
    Nat Biotechnol; 2000 Oct 01; 18(10):1105-8. PubMed ID: 11017052
    [Abstract] [Full Text] [Related]

  • 8. Potent inhibition of influenza sialidase by a benzoic acid containing a 2-pyrrolidinone substituent.
    Atigadda VR, Brouillette WJ, Duarte F, Ali SM, Babu YS, Bantia S, Chand P, Chu N, Montgomery JA, Walsh DA, Sudbeck EA, Finley J, Luo M, Air GM, Laver GW.
    J Med Chem; 1999 Jul 01; 42(13):2332-43. PubMed ID: 10395473
    [Abstract] [Full Text] [Related]

  • 9. Crystal structure of the bifunctional dihydroneopterin aldolase/6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase from Streptococcus pneumoniae.
    Garçon A, Levy C, Derrick JP.
    J Mol Biol; 2006 Jul 14; 360(3):644-53. PubMed ID: 16781731
    [Abstract] [Full Text] [Related]

  • 10. Strategy for discovering chemical inhibitors of human cyclophilin a: focused library design, virtual screening, chemical synthesis and bioassay.
    Li J, Zhang J, Chen J, Luo X, Zhu W, Shen J, Liu H, Shen X, Jiang H.
    J Comb Chem; 2006 Jul 14; 8(3):326-37. PubMed ID: 16677001
    [Abstract] [Full Text] [Related]

  • 11. Novel prostaglandin D synthase inhibitors generated by fragment-based drug design.
    Hohwy M, Spadola L, Lundquist B, Hawtin P, Dahmén J, Groth-Clausen I, Nilsson E, Persdotter S, von Wachenfeldt K, Folmer RH, Edman K.
    J Med Chem; 2008 Apr 10; 51(7):2178-86. PubMed ID: 18341273
    [Abstract] [Full Text] [Related]

  • 12. Identification, SAR studies, and X-ray co-crystallographic analysis of a novel furanopyrimidine aurora kinase A inhibitor.
    Coumar MS, Tsai MT, Chu CY, Uang BJ, Lin WH, Chang CY, Chang TY, Leou JS, Teng CH, Wu JS, Fang MY, Chen CH, Hsu JT, Wu SY, Chao YS, Hsieh HP.
    ChemMedChem; 2010 Feb 01; 5(2):255-67. PubMed ID: 20039358
    [Abstract] [Full Text] [Related]

  • 13. Structure-based optimization of aldose reductase inhibitors originating from virtual screening.
    Eisenmann M, Steuber H, Zentgraf M, Altenkämper M, Ortmann R, Perruchon J, Klebe G, Schlitzer M.
    ChemMedChem; 2009 May 01; 4(5):809-19. PubMed ID: 19301313
    [Abstract] [Full Text] [Related]

  • 14. Discovery and X-ray crystallographic analysis of a spiropiperidine iminohydantoin inhibitor of beta-secretase.
    Barrow JC, Stauffer SR, Rittle KE, Ngo PL, Yang Z, Selnick HG, Graham SL, Munshi S, McGaughey GB, Holloway MK, Simon AJ, Price EA, Sankaranarayanan S, Colussi D, Tugusheva K, Lai MT, Espeseth AS, Xu M, Huang Q, Wolfe A, Pietrak B, Zuck P, Levorse DA, Hazuda D, Vacca JP.
    J Med Chem; 2008 Oct 23; 51(20):6259-62. PubMed ID: 18811140
    [Abstract] [Full Text] [Related]

  • 15. Identification of novel p38alpha MAP kinase inhibitors using fragment-based lead generation.
    Gill AL, Frederickson M, Cleasby A, Woodhead SJ, Carr MG, Woodhead AJ, Walker MT, Congreve MS, Devine LA, Tisi D, O'Reilly M, Seavers LC, Davis DJ, Curry J, Anthony R, Padova A, Murray CW, Carr RA, Jhoti H.
    J Med Chem; 2005 Jan 27; 48(2):414-26. PubMed ID: 15658855
    [Abstract] [Full Text] [Related]

  • 16. Synthesis and structure-activity relationship for a novel class of potent and selective carbamoyl-triazole based inhibitors of hormone sensitive lipase.
    Ebdrup S, Sørensen LG, Olsen OH, Jacobsen P.
    J Med Chem; 2004 Jan 15; 47(2):400-10. PubMed ID: 14711311
    [Abstract] [Full Text] [Related]

  • 17. Structure-based design and synthesis of novel non-zinc chelating MMP-12 inhibitors.
    Dublanchet AC, Ducrot P, Andrianjara C, O'Gara M, Morales R, Compère D, Denis A, Blais S, Cluzeau P, Courté K, Hamon J, Moreau F, Prunet ML, Tertre A.
    Bioorg Med Chem Lett; 2005 Aug 15; 15(16):3787-90. PubMed ID: 16002291
    [Abstract] [Full Text] [Related]

  • 18. Rapid discovery of triazolobenzylidene-thiazolopyrimidines (TBTP) as CDC25 phosphatase inhibitors by parallel click chemistry and in situ screening.
    Duval R, Kolb S, Braud E, Genest D, Garbay C.
    J Comb Chem; 2009 Aug 15; 11(6):947-50. PubMed ID: 19835352
    [No Abstract] [Full Text] [Related]

  • 19. Synthesis and structure based optimization of novel Akt inhibitors.
    Lippa B, Pan G, Corbett M, Li C, Kauffman GS, Pandit J, Robinson S, Wei L, Kozina E, Marr ES, Borzillo G, Knauth E, Barbacci-Tobin EG, Vincent P, Troutman M, Baker D, Rajamohan F, Kakar S, Clark T, Morris J.
    Bioorg Med Chem Lett; 2008 Jun 01; 18(11):3359-63. PubMed ID: 18456494
    [Abstract] [Full Text] [Related]

  • 20. Discovery, synthesis and biological evaluation of isoquinolones as novel and highly selective JNK inhibitors (1).
    Asano Y, Kitamura S, Ohra T, Aso K, Igata H, Tamura T, Kawamoto T, Tanaka T, Sogabe S, Matsumoto S, Yamaguchi M, Kimura H, Itoh F.
    Bioorg Med Chem; 2008 Apr 15; 16(8):4715-32. PubMed ID: 18313304
    [Abstract] [Full Text] [Related]

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