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156 related items for PubMed ID: 15039296

  • 1. Assessment of arginine 97 and lysine 72 as determinants of substrate specificity in cytochrome P450 2C9 (CYP2C9).
    Davies C, Witham K, Scott JR, Pearson A, DeVoss JJ, Graham SE, Gillam EM.
    Drug Metab Dispos; 2004 Apr; 32(4):431-6. PubMed ID: 15039296
    [Abstract] [Full Text] [Related]

  • 2. Analysis of human cytochrome P450 2C8 substrate specificity using a substrate pharmacophore and site-directed mutants.
    Melet A, Marques-Soares C, Schoch GA, Macherey AC, Jaouen M, Dansette PM, Sari MA, Johnson EF, Mansuy D.
    Biochemistry; 2004 Dec 14; 43(49):15379-92. PubMed ID: 15581350
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  • 3. Role of conserved Asp293 of cytochrome P450 2C9 in substrate recognition and catalytic activity.
    Flanagan JU, McLaughlin LA, Paine MJ, Sutcliffe MJ, Roberts GC, Wolf CR.
    Biochem J; 2003 Mar 15; 370(Pt 3):921-6. PubMed ID: 12482324
    [Abstract] [Full Text] [Related]

  • 4. Differential roles of Arg97, Asp293, and Arg108 in enzyme stability and substrate specificity of CYP2C9.
    Dickmann LJ, Locuson CW, Jones JP, Rettie AE.
    Mol Pharmacol; 2004 Apr 15; 65(4):842-50. PubMed ID: 15044613
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  • 5. Arginines 97 and 108 in CYP2C9 are important determinants of the catalytic function.
    Ridderström M, Masimirembwa C, Trump-Kallmeyer S, Ahlefelt M, Otter C, Andersson TB.
    Biochem Biophys Res Commun; 2000 Apr 21; 270(3):983-7. PubMed ID: 10772937
    [Abstract] [Full Text] [Related]

  • 6. Enzymatic determinants of the substrate specificity of CYP2C9: role of B'-C loop residues in providing the pi-stacking anchor site for warfarin binding.
    Haining RL, Jones JP, Henne KR, Fisher MB, Koop DR, Trager WF, Rettie AE.
    Biochemistry; 1999 Mar 16; 38(11):3285-92. PubMed ID: 10079071
    [Abstract] [Full Text] [Related]

  • 7. Role of LYS271 and LYS279 residues in the interaction of cytochrome P4501A1 with NADPH-cytochrome P450 reductase.
    Cvrk T, Strobel HW.
    Arch Biochem Biophys; 2001 Jan 15; 385(2):290-300. PubMed ID: 11368010
    [Abstract] [Full Text] [Related]

  • 8. The substrate binding site of human liver cytochrome P450 2C9: an NMR study.
    Poli-Scaife S, Attias R, Dansette PM, Mansuy D.
    Biochemistry; 1997 Oct 21; 36(42):12672-82. PubMed ID: 9335524
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  • 14. Role of alphaArg145 and betaArg263 in the active site of penicillin acylase of Escherichia coli.
    Alkema WB, Prins AK, de Vries E, Janssen DB.
    Biochem J; 2002 Jul 01; 365(Pt 1):303-9. PubMed ID: 12071857
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  • 15. Allelic variants of human cytochrome P450 2C9: baculovirus-mediated expression, purification, structural characterization, substrate stereoselectivity, and prochiral selectivity of the wild-type and I359L mutant forms.
    Haining RL, Hunter AP, Veronese ME, Trager WF, Rettie AE.
    Arch Biochem Biophys; 1996 Sep 15; 333(2):447-58. PubMed ID: 8809086
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  • 17. Quantitative binding models for CYP2C9 based on benzbromarone analogues.
    Locuson CW, Rock DA, Jones JP.
    Biochemistry; 2004 Jun 08; 43(22):6948-58. PubMed ID: 15170332
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  • 18. New insights into the structural features and functional relevance of human cytochrome P450 2C9. Part II.
    Mo SL, Zhou ZW, Yang LP, Wei MQ, Zhou SF.
    Curr Drug Metab; 2009 Dec 08; 10(10):1127-50. PubMed ID: 20167000
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  • 19. Extending the diversity of cytochrome P450 enzymes by DNA family shuffling.
    Rosic NN, Huang W, Johnston WA, DeVoss JJ, Gillam EM.
    Gene; 2007 Jun 15; 395(1-2):40-8. PubMed ID: 17400405
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  • 20. The role of Arg-96 in Danio rerio creatine kinase in substrate recognition and active center configuration.
    Uda K, Kuwasaki A, Shima K, Matsumoto T, Suzuki T.
    Int J Biol Macromol; 2009 Jun 01; 44(5):413-8. PubMed ID: 19428475
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