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Journal Abstract Search

120 related items for PubMed ID: 15039298

  • 1. Incorporation of an oxygen from water into troglitazone quinone by cytochrome P450 and myeloperoxidase.
    He K, Talaat RE, Woolf TF.
    Drug Metab Dispos; 2004 Apr; 32(4):442-6. PubMed ID: 15039298
    [Abstract] [Full Text] [Related]

  • 2. Metabolic activation of troglitazone: identification of a reactive metabolite and mechanisms involved.
    He K, Talaat RE, Pool WF, Reily MD, Reed JE, Bridges AJ, Woolf TF.
    Drug Metab Dispos; 2004 Jun; 32(6):639-46. PubMed ID: 15155556
    [Abstract] [Full Text] [Related]

  • 3. Troglitazone quinone formation catalyzed by human and rat CYP3A: an atypical CYP oxidation reaction.
    He K, Woolf TF, Kindt EK, Fielder AE, Talaat RE.
    Biochem Pharmacol; 2001 Jul 15; 62(2):191-8. PubMed ID: 11389877
    [Abstract] [Full Text] [Related]

  • 4. Electrochemical oxidation of troglitazone: identification and characterization of the major reactive metabolite in liver microsomes.
    Madsen KG, Grönberg G, Skonberg C, Jurva U, Hansen SH, Olsen J.
    Chem Res Toxicol; 2008 Oct 15; 21(10):2035-41. PubMed ID: 18788755
    [Abstract] [Full Text] [Related]

  • 5. Enzyme-induction dependent bioactivation of troglitazone and troglitazone quinone in vivo.
    Tettey JN, Maggs JL, Rapeport WG, Pirmohamed M, Park BK.
    Chem Res Toxicol; 2001 Aug 15; 14(8):965-74. PubMed ID: 11511170
    [Abstract] [Full Text] [Related]

  • 6. Production of a reactive metabolite of troglitazone by electrochemical oxidation performed in nonaqueous medium.
    Tahara K, Nishikawa T, Hattori Y, Iijima S, Kouno Y, Abe Y.
    J Pharm Biomed Anal; 2009 Dec 05; 50(5):1030-6. PubMed ID: 19581066
    [Abstract] [Full Text] [Related]

  • 7. Mechanistic studies on the metabolic scission of thiazolidinedione derivatives to acyclic thiols.
    Reddy VB, Karanam BV, Gruber WL, Wallace MA, Vincent SH, Franklin RB, Baillie TA.
    Chem Res Toxicol; 2005 May 05; 18(5):880-8. PubMed ID: 15892582
    [Abstract] [Full Text] [Related]

  • 8. Troglitazone thiol adduct formation in human liver microsomes: enzyme kinetics and reaction phenotyping.
    Gan J, Qu Q, He B, Shyu WC, Rodrigues AD, He K.
    Drug Metab Lett; 2008 Aug 05; 2(3):184-9. PubMed ID: 19356091
    [Abstract] [Full Text] [Related]

  • 9. Toxic metabolite formation from Troglitazone (TGZ): new insights from a DFT study.
    Dixit VA, Bharatam PV.
    Chem Res Toxicol; 2011 Jul 18; 24(7):1113-22. PubMed ID: 21657230
    [Abstract] [Full Text] [Related]

  • 10. Thiazolidinedione bioactivation: a comparison of the bioactivation potentials of troglitazone, rosiglitazone, and pioglitazone using stable isotope-labeled analogues and liquid chromatography tandem mass spectrometry.
    Alvarez-Sanchez R, Montavon F, Hartung T, Pähler A.
    Chem Res Toxicol; 2006 Aug 18; 19(8):1106-16. PubMed ID: 16918252
    [Abstract] [Full Text] [Related]

  • 11. NADPH-dependent covalent binding of [3H]paroxetine to human liver microsomes and S-9 fractions: identification of an electrophilic quinone metabolite of paroxetine.
    Zhao SX, Dalvie DK, Kelly JM, Soglia JR, Frederick KS, Smith EB, Obach RS, Kalgutkar AS.
    Chem Res Toxicol; 2007 Nov 18; 20(11):1649-57. PubMed ID: 17907785
    [Abstract] [Full Text] [Related]

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  • 13. Oxidation of 9-alkylanthracenes by cytochrome P450 2B1, horseradish peroxidase, and iron tetraphenylporphine/iodosylbenzene systems: anaerobic and aerobic mechanisms.
    Anzenbacher P, Niwa T, Tolbert LM, Sirimanne SR, Guengerich FP.
    Biochemistry; 1996 Feb 27; 35(8):2512-20. PubMed ID: 8611554
    [Abstract] [Full Text] [Related]

  • 14. CYP2C8- and CYP3A-mediated C-demethylation of (3-{[(4-tert-butylbenzyl)-(pyridine-3-sulfonyl)-amino]-methyl}-phenoxy)-acetic acid (CP-533,536), an EP2 receptor-selective prostaglandin E2 agonist: characterization of metabolites by high-resolution liquid chromatography-tandem mass spectrometry and liquid chromatography/mass spectrometry-nuclear magnetic resonance.
    Prakash C, Wang W, O'Connell T, Johnson KA.
    Drug Metab Dispos; 2008 Oct 27; 36(10):2093-103. PubMed ID: 18653741
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  • 16. Hepatobiliary disposition of troglitazone and metabolites in rat and human sandwich-cultured hepatocytes: use of Monte Carlo simulations to assess the impact of changes in biliary excretion on troglitazone sulfate accumulation.
    Lee JK, Marion TL, Abe K, Lim C, Pollock GM, Brouwer KL.
    J Pharmacol Exp Ther; 2010 Jan 27; 332(1):26-34. PubMed ID: 19801447
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  • 18. Novel metabolic pathway of arylethers by cytochrome P450: cleavage of the oxygen-aromatic ring bond accompanying ipso-substitution by the oxygen atom of the active species in cytochrome P450 models and cytochrome P450.
    Ohe T, Mashino T, Hirobe M.
    Arch Biochem Biophys; 1994 May 01; 310(2):402-9. PubMed ID: 8179325
    [Abstract] [Full Text] [Related]

  • 19. In vitro metabolism study of combretastatin A-4 in rat and human liver microsomes.
    Aprile S, Del Grosso E, Tron GC, Grosa G.
    Drug Metab Dispos; 2007 Dec 01; 35(12):2252-61. PubMed ID: 17890446
    [Abstract] [Full Text] [Related]

  • 20. Identification of glutathione conjugates of troglitazone in human hepatocytes.
    Prabhu S, Fackett A, Lloyd S, McClellan HA, Terrell CM, Silber PM, Li AP.
    Chem Biol Interact; 2002 Nov 10; 142(1-2):83-97. PubMed ID: 12399157
    [Abstract] [Full Text] [Related]

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