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347 related items for PubMed ID: 15047908

  • 1. Ala226 to Gly and Ser189 to Asp mutations convert rat chymotrypsin B to a trypsin-like protease.
    Jelinek B, Antal J, Venekei I, Gráf L.
    Protein Eng Des Sel; 2004 Feb; 17(2):127-31. PubMed ID: 15047908
    [Abstract] [Full Text] [Related]

  • 2. The crystal structure of a trypsin-like mutant chymotrypsin: the role of position 226 in the activity and specificity of S189D chymotrypsin.
    Jelinek B, Katona G, Fodor K, Venekei I, Gráf L.
    Protein J; 2008 Feb; 27(2):79-87. PubMed ID: 17805946
    [Abstract] [Full Text] [Related]

  • 3. Three dimensional structures of S189D chymotrypsin and D189S trypsin mutants: the effect of polarity at site 189 on a protease-specific stabilization of the substrate-binding site.
    Szabó E, Venekei I, Böcskei Z, Náray-Szabó G, Gráf L.
    J Mol Biol; 2003 Aug 29; 331(5):1121-30. PubMed ID: 12927546
    [Abstract] [Full Text] [Related]

  • 4. Attempts to convert chymotrypsin to trypsin.
    Venekei I, Szilágyi L, Gráf L, Rutter WJ.
    FEBS Lett; 1996 Mar 25; 383(1-2):143-7. PubMed ID: 8612781
    [Abstract] [Full Text] [Related]

  • 5. Studies of specificity and catalysis in trypsin by structural analysis of site-directed mutants.
    Sprang SR, Fletterick RJ, Gráf L, Rutter WJ, Craik CS.
    Crit Rev Biotechnol; 1988 Mar 25; 8(3):225-36. PubMed ID: 3063392
    [Abstract] [Full Text] [Related]

  • 6. Attempts to convert chymotrypsin to trypsin.
    Venekei I, Szilágyi L, Gráf L, Rutter WJ.
    FEBS Lett; 1996 Jan 29; 379(2):143-7. PubMed ID: 8635580
    [Abstract] [Full Text] [Related]

  • 7. Converting trypsin to elastase: substitution of the S1 site and adjacent loops reconstitutes esterase specificity but not amidase activity.
    Hung SH, Hedstrom L.
    Protein Eng; 1998 Aug 29; 11(8):669-73. PubMed ID: 9749919
    [Abstract] [Full Text] [Related]

  • 8. Mapping the S' subsites of serine proteases using acyl transfer to mixtures of peptide nucleophiles.
    Schellenberger V, Turck CW, Hedstrom L, Rutter WJ.
    Biochemistry; 1993 Apr 27; 32(16):4349-53. PubMed ID: 8476865
    [Abstract] [Full Text] [Related]

  • 9. Trypsin: a case study in the structural determinants of enzyme specificity.
    Hedstrom L.
    Biol Chem; 1996 Apr 27; 377(7-8):465-70. PubMed ID: 8922280
    [Abstract] [Full Text] [Related]

  • 10. Mesotrypsin Signature Mutation in a Chymotrypsin C (CTRC) Variant Associated with Chronic Pancreatitis.
    Szabó A, Ludwig M, Hegyi E, Szépeová R, Witt H, Sahin-Tóth M.
    J Biol Chem; 2015 Jul 10; 290(28):17282-92. PubMed ID: 26013824
    [Abstract] [Full Text] [Related]

  • 11. Probes of the mechanism of zymogen catalysis.
    Lonsdale-Eccles JD, Neurath H, Walsh KA.
    Biochemistry; 1978 Jul 11; 17(14):2805-9. PubMed ID: 687564
    [Abstract] [Full Text] [Related]

  • 12. Properties of the His57-Asp102 dyad of rat trypsin D189S in the zymogen, activated enzyme, and alpha1-proteinase inhibitor complexed forms.
    Kaslik G, Westler WM, Gráf L, Markley JL.
    Arch Biochem Biophys; 1999 Feb 15; 362(2):254-64. PubMed ID: 9989934
    [Abstract] [Full Text] [Related]

  • 13. Crystal structure of bovine duodenase, a serine protease, with dual trypsin and chymotrypsin-like specificities.
    Pletnev VZ, Zamolodchikova TS, Pangborn WA, Duax WL.
    Proteins; 2000 Oct 01; 41(1):8-16. PubMed ID: 10944388
    [Abstract] [Full Text] [Related]

  • 14. Cloning and characterization of chymotrypsin- and trypsin-like cDNAs from the gut of the Hessian fly [Mayetiola destructor (Say)].
    Zhu YC, Liu X, Maddur AA, Oppert B, Chen MS.
    Insect Biochem Mol Biol; 2005 Jan 01; 35(1):23-32. PubMed ID: 15607652
    [Abstract] [Full Text] [Related]

  • 15. The role of disulfide bond C191-C220 in trypsin and chymotrypsin.
    Várallyay E, Lengyel Z, Gráf L, Szilágyi L.
    Biochem Biophys Res Commun; 1997 Jan 23; 230(3):592-6. PubMed ID: 9015368
    [Abstract] [Full Text] [Related]

  • 16. Alanine point-mutations in the reactive region of bovine pancreatic trypsin inhibitor: effects on the kinetics and thermodynamics of binding to beta-trypsin and alpha-chymotrypsin.
    Castro MJ, Anderson S.
    Biochemistry; 1996 Sep 03; 35(35):11435-46. PubMed ID: 8784199
    [Abstract] [Full Text] [Related]

  • 17. Converting trypsin to chymotrypsin: structural determinants of S1' specificity.
    Kurth T, Ullmann D, Jakubke HD, Hedstrom L.
    Biochemistry; 1997 Aug 19; 36(33):10098-104. PubMed ID: 9254605
    [Abstract] [Full Text] [Related]

  • 18. Electrostatic complementarity within the substrate-binding pocket of trypsin.
    Gráf L, Jancsó A, Szilágyi L, Hegyi G, Pintér K, Náray-Szabó G, Hepp J, Medzihradszky K, Rutter WJ.
    Proc Natl Acad Sci U S A; 1988 Jul 19; 85(14):4961-5. PubMed ID: 3134655
    [Abstract] [Full Text] [Related]

  • 19. Converting trypsin to chymotrypsin: residue 172 is a substrate specificity determinant.
    Hedstrom L, Perona JJ, Rutter WJ.
    Biochemistry; 1994 Jul 26; 33(29):8757-63. PubMed ID: 8038165
    [Abstract] [Full Text] [Related]

  • 20. Functional linkage between the active site of alpha-lytic protease and distant regions of structure: scanning alanine mutagenesis of a surface loop affects activity and substrate specificity.
    Mace JE, Wilk BJ, Agard DA.
    J Mol Biol; 1995 Aug 04; 251(1):116-34. PubMed ID: 7643381
    [Abstract] [Full Text] [Related]

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