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Journal Abstract Search


244 related items for PubMed ID: 15102439

  • 1. Tuberous sclerosis complex: from Drosophila to human disease.
    Pan D, Dong J, Zhang Y, Gao X.
    Trends Cell Biol; 2004 Feb; 14(2):78-85. PubMed ID: 15102439
    [Abstract] [Full Text] [Related]

  • 2. Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins.
    Zhang Y, Gao X, Saucedo LJ, Ru B, Edgar BA, Pan D.
    Nat Cell Biol; 2003 Jun; 5(6):578-81. PubMed ID: 12771962
    [Abstract] [Full Text] [Related]

  • 3. Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity.
    Li Y, Inoki K, Guan KL.
    Mol Cell Biol; 2004 Sep; 24(18):7965-75. PubMed ID: 15340059
    [Abstract] [Full Text] [Related]

  • 4. Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb.
    Tee AR, Manning BD, Roux PP, Cantley LC, Blenis J.
    Curr Biol; 2003 Aug 05; 13(15):1259-68. PubMed ID: 12906785
    [Abstract] [Full Text] [Related]

  • 5. Non-canonical functions of the tuberous sclerosis complex-Rheb signalling axis.
    Neuman NA, Henske EP.
    EMBO Mol Med; 2011 Apr 05; 3(4):189-200. PubMed ID: 21412983
    [Abstract] [Full Text] [Related]

  • 6. Rhebbing up mTOR: new insights on TSC1 and TSC2, and the pathogenesis of tuberous sclerosis.
    Kwiatkowski DJ.
    Cancer Biol Ther; 2003 Apr 05; 2(5):471-6. PubMed ID: 14614311
    [Abstract] [Full Text] [Related]

  • 7. Structure of the Tuberous Sclerosis Complex 2 (TSC2) N Terminus Provides Insight into Complex Assembly and Tuberous Sclerosis Pathogenesis.
    Zech R, Kiontke S, Mueller U, Oeckinghaus A, Kümmel D.
    J Biol Chem; 2016 Sep 16; 291(38):20008-20. PubMed ID: 27493206
    [Abstract] [Full Text] [Related]

  • 8. TSC1/TSC2 and Rheb have different effects on TORC1 and TORC2 activity.
    Yang Q, Inoki K, Kim E, Guan KL.
    Proc Natl Acad Sci U S A; 2006 May 02; 103(18):6811-6. PubMed ID: 16627617
    [Abstract] [Full Text] [Related]

  • 9. Drosophila TCTP is essential for growth and proliferation through regulation of dRheb GTPase.
    Hsu YC, Chern JJ, Cai Y, Liu M, Choi KW.
    Nature; 2007 Feb 15; 445(7129):785-8. PubMed ID: 17301792
    [Abstract] [Full Text] [Related]

  • 10. Temporal control of differentiation by the insulin receptor/tor pathway in Drosophila.
    Bateman JM, McNeill H.
    Cell; 2004 Oct 01; 119(1):87-96. PubMed ID: 15454083
    [Abstract] [Full Text] [Related]

  • 11. Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2.
    Garami A, Zwartkruis FJ, Nobukuni T, Joaquin M, Roccio M, Stocker H, Kozma SC, Hafen E, Bos JL, Thomas G.
    Mol Cell; 2003 Jun 01; 11(6):1457-66. PubMed ID: 12820960
    [Abstract] [Full Text] [Related]

  • 12. Recent advances in the regulation of the TOR pathway by insulin and nutrients.
    Avruch J, Lin Y, Long X, Murthy S, Ortiz-Vega S.
    Curr Opin Clin Nutr Metab Care; 2005 Jan 01; 8(1):67-72. PubMed ID: 15586002
    [Abstract] [Full Text] [Related]

  • 13. TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1.
    Dibble CC, Elis W, Menon S, Qin W, Klekota J, Asara JM, Finan PM, Kwiatkowski DJ, Murphy LO, Manning BD.
    Mol Cell; 2012 Aug 24; 47(4):535-46. PubMed ID: 22795129
    [Abstract] [Full Text] [Related]

  • 14. Rheb fills a GAP between TSC and TOR.
    Manning BD, Cantley LC.
    Trends Biochem Sci; 2003 Nov 24; 28(11):573-6. PubMed ID: 14607085
    [Abstract] [Full Text] [Related]

  • 15. The TSC1 and TSC2 tumor suppressors are required for proper ER stress response and protect cells from ER stress-induced apoptosis.
    Kang YJ, Lu MK, Guan KL.
    Cell Death Differ; 2011 Jan 24; 18(1):133-44. PubMed ID: 20616807
    [Abstract] [Full Text] [Related]

  • 16. Structural basis for the unique biological function of small GTPase RHEB.
    Yu Y, Li S, Xu X, Li Y, Guan K, Arnold E, Ding J.
    J Biol Chem; 2005 Apr 29; 280(17):17093-100. PubMed ID: 15728574
    [Abstract] [Full Text] [Related]

  • 17. Activation of Rheb, but not of mTORC1, impairs spine synapse morphogenesis in tuberous sclerosis complex.
    Yasuda S, Sugiura H, Katsurabayashi S, Shimada T, Tanaka H, Takasaki K, Iwasaki K, Kobayashi T, Hino O, Yamagata K.
    Sci Rep; 2014 Jun 03; 4():5155. PubMed ID: 24889507
    [Abstract] [Full Text] [Related]

  • 18. Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling.
    Inoki K, Li Y, Xu T, Guan KL.
    Genes Dev; 2003 Aug 01; 17(15):1829-34. PubMed ID: 12869586
    [Abstract] [Full Text] [Related]

  • 19. The TSC1-TSC2 complex: a molecular switchboard controlling cell growth.
    Huang J, Manning BD.
    Biochem J; 2008 Jun 01; 412(2):179-90. PubMed ID: 18466115
    [Abstract] [Full Text] [Related]

  • 20. Farnesyltransferase inhibitors reverse altered growth and distribution of actin filaments in Tsc-deficient cells via inhibition of both rapamycin-sensitive and -insensitive pathways.
    Gau CL, Kato-Stankiewicz J, Jiang C, Miyamoto S, Guo L, Tamanoi F.
    Mol Cancer Ther; 2005 Jun 01; 4(6):918-26. PubMed ID: 15956249
    [Abstract] [Full Text] [Related]


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