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188 related items for PubMed ID: 15123700

  • 1. Hindering the strand passage reaction of human topoisomerase IIalpha without disturbing DNA cleavage, ATP hydrolysis, or the operation of the N-terminal clamp.
    Oestergaard VH, Giangiacomo L, Bjergbaek L, Knudsen BR, Andersen AH.
    J Biol Chem; 2004 Jul 02; 279(27):28093-9. PubMed ID: 15123700
    [Abstract] [Full Text] [Related]

  • 2. Communication between the ATPase and cleavage/religation domains of human topoisomerase IIalpha.
    Bjergbaek L, Kingma P, Nielsen IS, Wang Y, Westergaard O, Osheroff N, Andersen AH.
    J Biol Chem; 2000 Apr 28; 275(17):13041-8. PubMed ID: 10777608
    [Abstract] [Full Text] [Related]

  • 3. The transducer domain is important for clamp operation in human DNA topoisomerase IIalpha.
    Oestergaard VH, Bjergbaek L, Skouboe C, Giangiacomo L, Knudsen BR, Andersen AH.
    J Biol Chem; 2004 Jan 16; 279(3):1684-91. PubMed ID: 14583603
    [Abstract] [Full Text] [Related]

  • 4. The QTK loop is essential for the communication between the N-terminal atpase domain and the central cleavage--ligation region in human topoisomerase IIalpha.
    Bendsen S, Oestergaard VH, Skouboe C, Brinch M, Knudsen BR, Andersen AH.
    Biochemistry; 2009 Jul 14; 48(27):6508-15. PubMed ID: 19485418
    [Abstract] [Full Text] [Related]

  • 5. A human topoisomerase II alpha heterodimer with only one ATP binding site can go through successive catalytic cycles.
    Skouboe C, Bjergbaek L, Oestergaard VH, Larsen MK, Knudsen BR, Andersen AH.
    J Biol Chem; 2003 Feb 21; 278(8):5768-74. PubMed ID: 12480934
    [Abstract] [Full Text] [Related]

  • 6. The impact of the C-terminal domain on the interaction of human DNA topoisomerase II α and β with DNA.
    Gilroy KL, Austin CA.
    PLoS One; 2011 Feb 16; 6(2):e14693. PubMed ID: 21358820
    [Abstract] [Full Text] [Related]

  • 7. Probing the interaction of the cytotoxic bisdioxopiperazine ICRF-193 with the closed enzyme clamp of human topoisomerase IIalpha.
    Patel S, Jazrawi E, Creighton AM, Austin CA, Fisher LM.
    Mol Pharmacol; 2000 Sep 16; 58(3):560-8. PubMed ID: 10953049
    [Abstract] [Full Text] [Related]

  • 8. The p53 tumor suppressor stimulates the catalytic activity of human topoisomerase IIalpha by enhancing the rate of ATP hydrolysis.
    Kwon Y, Shin BS, Chung IK.
    J Biol Chem; 2000 Jun 16; 275(24):18503-10. PubMed ID: 10764786
    [Abstract] [Full Text] [Related]

  • 9. Novel xanthone-polyamine conjugates as catalytic inhibitors of human topoisomerase IIα.
    Minniti E, Byl JAW, Riccardi L, Sissi C, Rosini M, De Vivo M, Minarini A, Osheroff N.
    Bioorg Med Chem Lett; 2017 Oct 15; 27(20):4687-4693. PubMed ID: 28919339
    [Abstract] [Full Text] [Related]

  • 10. A mutation in human topoisomerase II alpha whose expression is lethal in DNA repair-deficient yeast cells.
    Walker JV, Nitiss KC, Jensen LH, Mayne C, Hu T, Jensen PB, Sehested M, Hsieh T, Nitiss JL.
    J Biol Chem; 2004 Jun 18; 279(25):25947-54. PubMed ID: 15037624
    [Abstract] [Full Text] [Related]

  • 11. Protein kinase C modulates the catalytic activity of topoisomerase II by enhancing the rate of ATP hydrolysis: evidence for a common mechanism of regulation by phosphorylation.
    Corbett AH, Fernald AW, Osheroff N.
    Biochemistry; 1993 Mar 02; 32(8):2090-7. PubMed ID: 8383533
    [Abstract] [Full Text] [Related]

  • 12. The DNA dependence of the ATPase activity of human DNA topoisomerase IIalpha.
    Hammonds TR, Maxwell A.
    J Biol Chem; 1997 Dec 19; 272(51):32696-703. PubMed ID: 9405488
    [Abstract] [Full Text] [Related]

  • 13. DNA cleavage and religation by human topoisomerase II alpha at high temperature.
    Bromberg KD, Osheroff N.
    Biochemistry; 2001 Jul 27; 40(28):8410-8. PubMed ID: 11444988
    [Abstract] [Full Text] [Related]

  • 14. Human small cell lung cancer NYH cells selected for resistance to the bisdioxopiperazine topoisomerase II catalytic inhibitor ICRF-187 demonstrate a functional R162Q mutation in the Walker A consensus ATP binding domain of the alpha isoform.
    Wessel I, Jensen LH, Jensen PB, Falck J, Rose A, Roerth M, Nitiss JL, Sehested M.
    Cancer Res; 1999 Jul 15; 59(14):3442-50. PubMed ID: 10416608
    [Abstract] [Full Text] [Related]

  • 15. Mutagenesis of E477 or K505 in the B' domain of human topoisomerase II beta increases the requirement for magnesium ions during strand passage.
    West KL, Meczes EL, Thorn R, Turnbull RM, Marshall R, Austin CA.
    Biochemistry; 2000 Feb 15; 39(6):1223-33. PubMed ID: 10684600
    [Abstract] [Full Text] [Related]

  • 16. Characterisation of the DNA-dependent ATPase activity of human DNA topoisomerase IIbeta: mutation of Ser165 in the ATPase domain reduces the ATPase activity and abolishes the in vivo complementation ability.
    West KL, Turnbull RM, Willmore E, Lakey JH, Austin CA.
    Nucleic Acids Res; 2002 Dec 15; 30(24):5416-24. PubMed ID: 12490710
    [Abstract] [Full Text] [Related]

  • 17. Impact of the C-terminal domain of topoisomerase IIalpha on the DNA cleavage activity of the human enzyme.
    Dickey JS, Osheroff N.
    Biochemistry; 2005 Aug 30; 44(34):11546-54. PubMed ID: 16114891
    [Abstract] [Full Text] [Related]

  • 18. Mutation of cysteine residue 455 to alanine in human topoisomerase IIalpha confers hypersensitivity to quinones: enhancing DNA scission by closing the N-terminal protein gate.
    Bender RP, Osheroff N.
    Chem Res Toxicol; 2007 Jun 30; 20(6):975-81. PubMed ID: 17516663
    [Abstract] [Full Text] [Related]

  • 19. HMGB1 interacts with human topoisomerase IIalpha and stimulates its catalytic activity.
    Stros M, Bacíková A, Polanská E, Stokrová J, Strauss F.
    Nucleic Acids Res; 2007 Jun 30; 35(15):5001-13. PubMed ID: 17636313
    [Abstract] [Full Text] [Related]

  • 20. Stability of the topoisomerase II closed clamp conformation may influence DNA-stimulated ATP hydrolysis.
    Vaughn J, Huang S, Wessel I, Sorensen TK, Hsieh T, Jensen LH, Jensen PB, Sehested M, Nitiss JL.
    J Biol Chem; 2005 Mar 25; 280(12):11920-9. PubMed ID: 15647268
    [Abstract] [Full Text] [Related]

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