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Journal Abstract Search

189 related items for PubMed ID: 15125950

  • 1. 3,4-Dihydronaphthalen-1(2H)-ones: novel ligands for the benzodiazepine site of alpha5-containing GABAA receptors.
    Szekeres HJ, Atack JR, Chambers MS, Cook SM, Macaulay AJ, Pillai GV, MacLeod AM.
    Bioorg Med Chem Lett; 2004 Jun 07; 14(11):2871-5. PubMed ID: 15125950
    [Abstract] [Full Text] [Related]

  • 2. Predictive models for GABAA/benzodiazepine receptor subtypes: studies of quantitative structure-activity relationships for imidazobenzodiazepines at five recombinant GABAA/benzodiazepine receptor subtypes [alphaxbeta3gamma2 (x = 1-3, 5, and 6)] via comparative molecular field analysis.
    Huang Q, Liu R, Zhang P, He X, McKernan R, Gan T, Bennett DW, Cook JM.
    J Med Chem; 1998 Oct 08; 41(21):4130-42. PubMed ID: 9767648
    [Abstract] [Full Text] [Related]

  • 3. Identification of a novel, selective GABA(A) alpha5 receptor inverse agonist which enhances cognition.
    Chambers MS, Atack JR, Broughton HB, Collinson N, Cook S, Dawson GR, Hobbs SC, Marshall G, Maubach KA, Pillai GV, Reeve AJ, MacLeod AM.
    J Med Chem; 2003 May 22; 46(11):2227-40. PubMed ID: 12747794
    [Abstract] [Full Text] [Related]

  • 4. The proconvulsant effects of the GABAA alpha5 subtype-selective compound RY-080 may not be alpha5-mediated.
    Atack JR, Bayley PJ, Fletcher SR, McKernan RM, Wafford KA, Dawson GR.
    Eur J Pharmacol; 2006 Oct 24; 548(1-3):77-82. PubMed ID: 16962577
    [Abstract] [Full Text] [Related]

  • 5. Synthesis and biological evaluation of 3-heterocyclyl-7,8,9,10-tetrahydro-(7,10-ethano)-1,2,4-triazolo[3,4-a]phthalazines and analogues as subtype-selective inverse agonists for the GABA(A)alpha5 benzodiazepine binding site.
    Street LJ, Sternfeld F, Jelley RA, Reeve AJ, Carling RW, Moore KW, McKernan RM, Sohal B, Cook S, Pike A, Dawson GR, Bromidge FA, Wafford KA, Seabrook GR, Thompson SA, Marshall G, Pillai GV, Castro JL, Atack JR, MacLeod AM.
    J Med Chem; 2004 Jul 01; 47(14):3642-57. PubMed ID: 15214791
    [Abstract] [Full Text] [Related]

  • 6. Differential contribution of GABA(A) receptor subtypes to the anticonvulsant efficacy of benzodiazepine site ligands.
    Fradley RL, Guscott MR, Bull S, Hallett DJ, Goodacre SC, Wafford KA, Garrett EM, Newman RJ, O'Meara GF, Whiting PJ, Rosahl TW, Dawson GR, Reynolds DS, Atack JR.
    J Psychopharmacol; 2007 Jun 01; 21(4):384-91. PubMed ID: 17092983
    [Abstract] [Full Text] [Related]

  • 7. Native gamma-aminobutyric acid type A receptors from rat hippocampus, containing both alpha 1 and alpha 5 subunits, exhibit a single benzodiazepine binding site with alpha 5 pharmacological properties.
    Araujo F, Ruano D, Vitorica J.
    J Pharmacol Exp Ther; 1999 Sep 01; 290(3):989-97. PubMed ID: 10454469
    [Abstract] [Full Text] [Related]

  • 8. Covalent modification of GABAA receptor isoforms by a diazepam analogue provides evidence for a novel benzodiazepine binding site that prevents modulation by these drugs.
    Baur R, Tan KR, Lüscher BP, Gonthier A, Goeldner M, Sigel E.
    J Neurochem; 2008 Sep 01; 106(6):2353-63. PubMed ID: 18643789
    [Abstract] [Full Text] [Related]

  • 9. 2,5-Dihydropyrazolo[4,3-c]pyridin-3-ones: functionally selective benzodiazepine binding site ligands on the GABAA receptor.
    Mitchinson A, Atack JR, Blurton P, Carling RW, Castro JL, Curley KS, Russell MG, Marshall G, McKernan RM, Moore KW, Narquizian R, Smith A, Street LJ, Thompson SA, Wafford K.
    Bioorg Med Chem Lett; 2004 Jul 05; 14(13):3441-4. PubMed ID: 15177449
    [Abstract] [Full Text] [Related]

  • 10. GABAA receptor pharmacology of fluorinated derivatives of the novel sedative-hypnotic pyrazolopyrimidine indiplon.
    Wegner F, Deuther-Conrad W, Scheunemann M, Brust P, Fischer S, Hiller A, Diekers M, Strecker K, Wohlfarth K, Allgaier C, Steinbach J, Hoepping A.
    Eur J Pharmacol; 2008 Feb 02; 580(1-2):1-11. PubMed ID: 18035350
    [Abstract] [Full Text] [Related]

  • 11. In vivo labelling of alpha5 subunit-containing GABA(A) receptors using the selective radioligand [(3)H]L-655,708.
    Atack JR, Alder L, Cook SM, Smith AJ, McKernan RM.
    Neuropharmacology; 2005 Aug 02; 49(2):220-9. PubMed ID: 15996568
    [Abstract] [Full Text] [Related]

  • 12. Type A gamma-aminobutyric acid (GABAA) receptor subunits and benzodiazepine binding: significance to clinical syndromes and their treatment.
    Smith TA.
    Br J Biomed Sci; 2001 Aug 02; 58(2):111-21. PubMed ID: 11440203
    [Abstract] [Full Text] [Related]

  • 13. TPA023 [7-(1,1-dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine], an agonist selective for alpha2- and alpha3-containing GABAA receptors, is a nonsedating anxiolytic in rodents and primates.
    Atack JR, Wafford KA, Tye SJ, Cook SM, Sohal B, Pike A, Sur C, Melillo D, Bristow L, Bromidge F, Ragan I, Kerby J, Street L, Carling R, Castro JL, Whiting P, Dawson GR, McKernan RM.
    J Pharmacol Exp Ther; 2006 Jan 02; 316(1):410-22. PubMed ID: 16183706
    [Abstract] [Full Text] [Related]

  • 14. 2,3,7-Trisubstituted pyrazolo[1,5-d][1,2,4]triazines: functionally selective GABAA alpha3-subtype agonists.
    Carling RW, Russell MG, Moore KW, Mitchinson A, Guiblin A, Smith A, Wafford KA, Marshall G, Atack JR, Street LJ.
    Bioorg Med Chem Lett; 2006 Jul 01; 16(13):3550-4. PubMed ID: 16621541
    [Abstract] [Full Text] [Related]

  • 15. Affinity of 3-acyl substituted 4-quinolones at the benzodiazepine site of GABA(A) receptors.
    Lager E, Nilsson J, Østergaard Nielsen E, Nielsen M, Liljefors T, Sterner O.
    Bioorg Med Chem; 2008 Jul 15; 16(14):6936-48. PubMed ID: 18541432
    [Abstract] [Full Text] [Related]

  • 16. Two neighboring residues of loop A of the alpha1 subunit point towards the benzodiazepine binding site of GABAA receptors.
    Tan KR, Baur R, Gonthier A, Goeldner M, Sigel E.
    FEBS Lett; 2007 Oct 02; 581(24):4718-22. PubMed ID: 17854801
    [Abstract] [Full Text] [Related]

  • 17. A new pyridazine series of GABAA alpha5 ligands.
    van Niel MB, Wilson K, Adkins CH, Atack JR, Castro JL, Clarke DE, Fletcher S, Gerhard U, Mackey MM, Malpas S, Maubach K, Newman R, O'Connor D, Pillai GV, Simpson PB, Thomas SR, MacLeod AM.
    J Med Chem; 2005 Sep 22; 48(19):6004-11. PubMed ID: 16162003
    [Abstract] [Full Text] [Related]

  • 18. Exploring subtype selectivity and metabolic stability of a novel series of ligands for the benzodiazepine binding site of the GABAA receptor.
    Hintermann S, Hurth K, Nozulak J, Tintelnot-Blomley M, Aichholz R, Blanz J, Kaupmann K, Mosbacher J.
    Bioorg Med Chem Lett; 2011 Mar 01; 21(5):1523-6. PubMed ID: 21277199
    [Abstract] [Full Text] [Related]

  • 19. GABAA receptor subtype-selective modulators. II. α5-selective inverse agonists for cognition enhancement.
    Atack JR.
    Curr Top Med Chem; 2011 Mar 01; 11(9):1203-14. PubMed ID: 21050171
    [Abstract] [Full Text] [Related]

  • 20. Studies of molecular pharmacophore/receptor models for GABAA/BzR subtypes: binding affinities of symmetrically substituted pyrazolo[4,3-c]quinolin-3-ones at recombinant alpha x beta 3 gamma 2 subtypes and quantitative structure-activity relationship studies via a comparative molecular field analysis.
    He X, Huang Q, Yu S, Ma C, McKernan R, Cook JM.
    Drug Des Discov; 1999 Jul 01; 16(1):77-91. PubMed ID: 10466058
    [Abstract] [Full Text] [Related]

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