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Journal Abstract Search

176 related items for PubMed ID: 15125967

  • 1. Identification of purine inhibitors of phosphodiesterase 7 (PDE7).
    Pitts WJ, Vaccaro W, Huynh T, Leftheris K, Roberge JY, Barbosa J, Guo J, Brown B, Watson A, Donaldson K, Starling GC, Kiener PA, Poss MA, Dodd JH, Barrish JC.
    Bioorg Med Chem Lett; 2004 Jun 07; 14(11):2955-8. PubMed ID: 15125967
    [Abstract] [Full Text] [Related]

  • 2. Fused pyrimidine based inhibitors of phosphodiesterase 7 (PDE7): synthesis and initial structure-activity relationships.
    Kempson J, Pitts WJ, Barbosa J, Guo J, Omotoso O, Watson A, Stebbins K, Starling GC, Dodd JH, Barrish JC, Felix R, Fischer K.
    Bioorg Med Chem Lett; 2005 Apr 01; 15(7):1829-33. PubMed ID: 15780616
    [Abstract] [Full Text] [Related]

  • 3. Spiroquinazolinones as novel, potent, and selective PDE7 inhibitors. Part 1.
    Lorthiois E, Bernardelli P, Vergne F, Oliveira C, Mafroud AK, Proust E, Heuze L, Moreau F, Idrissi M, Tertre A, Bertin B, Coupe M, Wrigglesworth R, Descours A, Soulard P, Berna P.
    Bioorg Med Chem Lett; 2004 Sep 20; 14(18):4623-6. PubMed ID: 15324876
    [Abstract] [Full Text] [Related]

  • 4. Discovery of thiadiazoles as a novel structural class of potent and selective PDE7 inhibitors. Part 1: design, synthesis and structure-activity relationship studies.
    Vergne F, Bernardelli P, Lorthiois E, Pham N, Proust E, Oliveira C, Mafroud AK, Royer F, Wrigglesworth R, Schellhaas J, Barvian M, Moreau F, Idrissi M, Tertre A, Bertin B, Coupe M, Berna P, Soulard P.
    Bioorg Med Chem Lett; 2004 Sep 20; 14(18):4607-13. PubMed ID: 15324874
    [Abstract] [Full Text] [Related]

  • 5. Synthesis and structure-activity relationships of guanine analogues as phosphodiesterase 7 (PDE7) inhibitors.
    Barnes MJ, Cooper N, Davenport RJ, Dyke HJ, Galleway FP, Galvin FC, Gowers L, Haughan AF, Lowe C, Meissner JW, Montana JG, Morgan T, Picken CL, Watson RJ.
    Bioorg Med Chem Lett; 2001 Apr 23; 11(8):1081-3. PubMed ID: 11327595
    [Abstract] [Full Text] [Related]

  • 6. Identification of potent pyrimidine inhibitors of phosphodiesterase 7 (PDE7) and their ability to inhibit T cell proliferation.
    Guo J, Watson A, Kempson J, Carlsen M, Barbosa J, Stebbins K, Lee D, Dodd J, Nadler SG, McKinnon M, Barrish J, Pitts WJ.
    Bioorg Med Chem Lett; 2009 Apr 01; 19(7):1935-8. PubMed ID: 19272774
    [Abstract] [Full Text] [Related]

  • 7. Selective inhibitors of cyclic AMP-specific phosphodiesterase: heterocycle-condensed purines.
    Sawanishi H, Suzuki H, Yamamoto S, Waki Y, Kasugai S, Ohya K, Suzuki N, Miyamoto K, Takagi K.
    J Med Chem; 1997 Sep 26; 40(20):3248-53. PubMed ID: 9379444
    [Abstract] [Full Text] [Related]

  • 8. 9-Benzyladenines: potent and selective cAMP phosphodiesterase inhibitors.
    Bourguignon JJ, Désaubry L, Raboisson P, Wermuth CG, Lugnier C.
    J Med Chem; 1997 Jun 06; 40(12):1768-70. PubMed ID: 9191951
    [No Abstract] [Full Text] [Related]

  • 9. Spiroquinazolinones as novel, potent, and selective PDE7 inhibitors. Part 2: Optimization of 5,8-disubstituted derivatives.
    Bernardelli P, Lorthiois E, Vergne F, Oliveira C, Mafroud AK, Proust E, Pham N, Ducrot P, Moreau F, Idrissi M, Tertre A, Bertin B, Coupe M, Chevalier E, Descours A, Berlioz-Seux F, Berna P, Li M.
    Bioorg Med Chem Lett; 2004 Sep 20; 14(18):4627-31. PubMed ID: 15324877
    [Abstract] [Full Text] [Related]

  • 10. Phosphodiesterase 4 isoenzyme inhibitory activity of 3-phenylxanthines and 4-pheny.
    Suzuki H, Sawanishi H, Yamamoto K, Yokogawa K, Miyamoto K.
    Chem Pharm Bull (Tokyo); 2001 Feb 20; 49(2):188-91. PubMed ID: 11217107
    [Abstract] [Full Text] [Related]

  • 11. Discovery of thiadiazoles as a novel structural class of potent and selective PDE7 inhibitors. Part 2: metabolism-directed optimization studies towards orally bioavailable derivatives.
    Vergne F, Bernardelli P, Lorthiois E, Pham N, Proust E, Oliveira C, Mafroud AK, Ducrot P, Wrigglesworth R, Berlioz-Seux F, Coleon F, Chevalier E, Moreau F, Idrissi M, Tertre A, Descours A, Berna P, Li M.
    Bioorg Med Chem Lett; 2004 Sep 20; 14(18):4615-21. PubMed ID: 15324875
    [Abstract] [Full Text] [Related]

  • 12. Discovery of BRL 50481 [3-(N,N-dimethylsulfonamido)-4-methyl-nitrobenzene], a selective inhibitor of phosphodiesterase 7: in vitro studies in human monocytes, lung macrophages, and CD8+ T-lymphocytes.
    Smith SJ, Cieslinski LB, Newton R, Donnelly LE, Fenwick PS, Nicholson AG, Barnes PJ, Barnette MS, Giembycz MA.
    Mol Pharmacol; 2004 Dec 20; 66(6):1679-89. PubMed ID: 15371556
    [Abstract] [Full Text] [Related]

  • 13. 2,1,3-Benzothiadiazine derivatives: synthesis and screening versus PDE4 enzyme.
    Tait A, Luppi A, Avallone R, Baraldi M.
    Farmaco; 2005 Aug 20; 60(8):653-63. PubMed ID: 15963514
    [Abstract] [Full Text] [Related]

  • 14. First dual M3 antagonists-PDE4 inhibitors: synthesis and SAR of 4,6-diaminopyrimidine derivatives.
    Provins L, Christophe B, Danhaive P, Dulieu J, Durieu V, Gillard M, Lebon F, Lengelé S, Quéré L, van Keulen B.
    Bioorg Med Chem Lett; 2006 Apr 01; 16(7):1834-9. PubMed ID: 16439121
    [Abstract] [Full Text] [Related]

  • 15. Phosphodiesterase inhibitors in airways disease.
    Fan Chung K.
    Eur J Pharmacol; 2006 Mar 08; 533(1-3):110-7. PubMed ID: 16458289
    [Abstract] [Full Text] [Related]

  • 16. Implications of PDE4 structure on inhibitor selectivity across PDE families.
    Ke H.
    Int J Impot Res; 2004 Jun 08; 16 Suppl 1():S24-7. PubMed ID: 15224132
    [Abstract] [Full Text] [Related]

  • 17. Design and synthesis of novel imidazo[1,2-a]quinoxalines as PDE4 inhibitors.
    Deleuze-Masquéfa C, Gerebtzoff G, Subra G, Fabreguettes JR, Ovens A, Carraz M, Strub MP, Bompart J, George P, Bonnet PA.
    Bioorg Med Chem; 2004 Mar 01; 12(5):1129-39. PubMed ID: 14980625
    [Abstract] [Full Text] [Related]

  • 18. Synthesis and cyclic AMP phosphodiesterase 4 isoenzyme inhibitory activity of heterocycle condensed purines.
    Suzuki H, Yamamoto M, Shimura S, Miyamoto K, Yamamoto K, Sawanishi H.
    Chem Pharm Bull (Tokyo); 2002 Sep 01; 50(9):1163-8. PubMed ID: 12237530
    [Abstract] [Full Text] [Related]

  • 19. Enaminones 9. Further studies on the anticonvulsant activity and potential type IV phosphodiesterase inhibitory activity of substituted vinylic benzamides.
    Anderson AJ, Nicholson JM, Bakare O, Butcher RJ, Wilson TL, Scott KR.
    Bioorg Med Chem; 2006 Feb 15; 14(4):997-1006. PubMed ID: 16219468
    [Abstract] [Full Text] [Related]

  • 20. Cyclic nucleotide phosphodiesterases (PDEs) in human osteoblastic cells; the effect of PDE inhibition on cAMP accumulation.
    Ahlström M, Pekkinen M, Huttunen M, Lamberg-Allardt C.
    Cell Mol Biol Lett; 2005 Feb 15; 10(2):305-19. PubMed ID: 16010295
    [Abstract] [Full Text] [Related]

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