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Journal Abstract Search

151 related items for PubMed ID: 15139759

  • 1. Syntheses and characterization of the acyl glucuronide and hydroxy metabolites of diclofenac.
    Kenny JR, Maggs JL, Meng X, Sinnott D, Clarke SE, Park BK, Stachulski AV.
    J Med Chem; 2004 May 20; 47(11):2816-25. PubMed ID: 15139759
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  • 3. Extrapolation of diclofenac clearance from in vitro microsomal metabolism data: role of acyl glucuronidation and sequential oxidative metabolism of the acyl glucuronide.
    Kumar S, Samuel K, Subramanian R, Braun MP, Stearns RA, Chiu SH, Evans DC, Baillie TA.
    J Pharmacol Exp Ther; 2002 Dec 20; 303(3):969-78. PubMed ID: 12438516
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  • 4. Determination of degradation pathways and kinetics of acyl glucuronides by NMR spectroscopy.
    Walker GS, Atherton J, Bauman J, Kohl C, Lam W, Reily M, Lou Z, Mutlib A.
    Chem Res Toxicol; 2007 Jun 20; 20(6):876-86. PubMed ID: 17536843
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  • 5. Identification of quinone imine containing glutathione conjugates of diclofenac in rat bile.
    Waldon DJ, Teffera Y, Colletti AE, Liu J, Zurcher D, Copeland KW, Zhao Z.
    Chem Res Toxicol; 2010 Dec 20; 23(12):1947-53. PubMed ID: 21053927
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  • 6. Identification of a novel glutathione adduct of diclofenac, 4'-hydroxy-2'-glutathion-deschloro-diclofenac, upon incubation with human liver microsomes.
    Yu LJ, Chen Y, Deninno MP, O'Connell TN, Hop CE.
    Drug Metab Dispos; 2005 Apr 20; 33(4):484-8. PubMed ID: 15640374
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  • 8. Mechanism of covalent adduct formation of diclofenac to rat hepatic microsomal proteins. Retention of the glucuronic acid moiety in the adduct.
    Kretz-Rommel A, Boelsterli UA.
    Drug Metab Dispos; 1994 Apr 20; 22(6):956-61. PubMed ID: 7895615
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  • 9. Gamma-glutamyltranspeptidase-mediated degradation of diclofenac-S-acyl-glutathione in vitro and in vivo in rat.
    Grillo MP, Hua F, March KL, Benet LZ, Knutson CG, Ware JA.
    Chem Res Toxicol; 2008 Oct 20; 21(10):1933-8. PubMed ID: 18693772
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  • 12. Enzymatic and microbial transformation assays for the evaluation of the environmental fate of diclofenac and its metabolites.
    Lee HJ, Lee E, Yoon SH, Chang HR, Kim K, Kwon JH.
    Chemosphere; 2012 May 20; 87(8):969-74. PubMed ID: 22401746
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  • 13. Bioactivation of diclofenac in vitro and in vivo: correlation to electrochemical studies.
    Madsen KG, Skonberg C, Jurva U, Cornett C, Hansen SH, Johansen TN, Olsen J.
    Chem Res Toxicol; 2008 May 20; 21(5):1107-19. PubMed ID: 18419141
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  • 14. Synthesis of 1-beta-O-acyl glucuronides of diclofenac, mefenamic acid and (S)-naproxen by the chemo-selective enzymatic removal of protecting groups from the corresponding methyl acetyl derivatives.
    Baba A, Yoshioka T.
    Org Biomol Chem; 2006 Sep 07; 4(17):3303-10. PubMed ID: 17036119
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  • 15. In vivo perturbation of rat hepatocyte canalicular membrane function by diclofenac.
    Sallustio BC, Holbrook FL.
    Drug Metab Dispos; 2001 Dec 07; 29(12):1535-8. PubMed ID: 11717171
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  • 16. Effective synthesis of 1beta-acyl glucuronides by selective acylation.
    Perrie JA, Harding JR, Holt DW, Johnston A, Meath P, Stachulski AV.
    Org Lett; 2005 Jun 23; 7(13):2591-4. PubMed ID: 15957898
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  • 17. Role of benoxaprofen and flunoxaprofen acyl glucuronides in covalent binding to rat plasma and liver proteins in vivo.
    Dong JQ, Liu J, Smith PC.
    Biochem Pharmacol; 2005 Sep 15; 70(6):937-48. PubMed ID: 16046212
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  • 18. Acyl glucuronides: the good, the bad and the ugly.
    Regan SL, Maggs JL, Hammond TG, Lambert C, Williams DP, Park BK.
    Biopharm Drug Dispos; 2010 Oct 15; 31(7):367-95. PubMed ID: 20830700
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  • 19. Covalent binding of zomepirac glucuronide to proteins: evidence for a Schiff base mechanism.
    Smith PC, Benet LZ, McDonagh AF.
    Drug Metab Dispos; 1990 Oct 15; 18(5):639-44. PubMed ID: 1981713
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  • 20. Formation and protein binding of the acyl glucuronide of a leukotriene B4 antagonist (SB-209247): relation to species differences in hepatotoxicity.
    Kenny JR, Maggs JL, Tettey JN, Harrell AW, Parker SG, Clarke SE, Park BK.
    Drug Metab Dispos; 2005 Feb 15; 33(2):271-81. PubMed ID: 15523047
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