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Journal Abstract Search

69 related items for PubMed ID: 15147304

  • 1. Nicotine reduces A beta in the brain and cerebral vessels of APPsw mice.
    Hellström-Lindahl E, Court J, Keverne J, Svedberg M, Lee M, Marutle A, Thomas A, Perry E, Bednar I, Nordberg A.
    Eur J Neurosci; 2004 May; 19(10):2703-10. PubMed ID: 15147304
    [Abstract] [Full Text] [Related]

  • 2. Dynamics of {beta}-amyloid reductions in brain, cerebrospinal fluid, and plasma of {beta}-amyloid precursor protein transgenic mice treated with a {gamma}-secretase inhibitor.
    Barten DM, Guss VL, Corsa JA, Loo A, Hansel SB, Zheng M, Munoz B, Srinivasan K, Wang B, Robertson BJ, Polson CT, Wang J, Roberts SB, Hendrick JP, Anderson JJ, Loy JK, Denton R, Verdoorn TA, Smith DW, Felsenstein KM.
    J Pharmacol Exp Ther; 2005 Feb; 312(2):635-43. PubMed ID: 15452193
    [Abstract] [Full Text] [Related]

  • 3. Age-dependent time course of cerebral brain-derived neurotrophic factor, nerve growth factor, and neurotrophin-3 in APP23 transgenic mice.
    Schulte-Herbrüggen O, Eckart S, Deicke U, Kühl A, Otten U, Danker-Hopfe H, Abramowski D, Staufenbiel M, Hellweg R.
    J Neurosci Res; 2008 Sep; 86(12):2774-83. PubMed ID: 18438945
    [Abstract] [Full Text] [Related]

  • 4. Apolipoprotein E modulates gamma-secretase cleavage of the amyloid precursor protein.
    Irizarry MC, Deng A, Lleo A, Berezovska O, Von Arnim CA, Martin-Rehrmann M, Manelli A, LaDu MJ, Hyman BT, Rebeck GW.
    J Neurochem; 2004 Sep; 90(5):1132-43. PubMed ID: 15312168
    [Abstract] [Full Text] [Related]

  • 5. In vivo beta-secretase 1 inhibition leads to brain Abeta lowering and increased alpha-secretase processing of amyloid precursor protein without effect on neuregulin-1.
    Sankaranarayanan S, Price EA, Wu G, Crouthamel MC, Shi XP, Tugusheva K, Tyler KX, Kahana J, Ellis J, Jin L, Steele T, Stachel S, Coburn C, Simon AJ.
    J Pharmacol Exp Ther; 2008 Mar; 324(3):957-69. PubMed ID: 18156464
    [Abstract] [Full Text] [Related]

  • 6. The novel beta-secretase inhibitor KMI-429 reduces amyloid beta peptide production in amyloid precursor protein transgenic and wild-type mice.
    Asai M, Hattori C, Iwata N, Saido TC, Sasagawa N, Szabó B, Hashimoto Y, Maruyama K, Tanuma S, Kiso Y, Ishiura S.
    J Neurochem; 2006 Jan; 96(2):533-40. PubMed ID: 16336629
    [Abstract] [Full Text] [Related]

  • 7. Absence of effect of chronic nicotine administration on amyloid beta peptide levels in transgenic mice overexpressing mutated human APP (Sw, Ind).
    Sabbagh MN, Walker DG, Reid RT, Stadnick T, Anand K, Lue LF.
    Neurosci Lett; 2008 Dec 26; 448(2):217-20. PubMed ID: 18926877
    [Abstract] [Full Text] [Related]

  • 8. P-glycoprotein efflux and other factors limit brain amyloid beta reduction by beta-site amyloid precursor protein-cleaving enzyme 1 inhibitors in mice.
    Meredith JE, Thompson LA, Toyn JH, Marcin L, Barten DM, Marcinkeviciene J, Kopcho L, Kim Y, Lin A, Guss V, Burton C, Iben L, Polson C, Cantone J, Ford M, Drexler D, Fiedler T, Lentz KA, Grace JE, Kolb J, Corsa J, Pierdomenico M, Jones K, Olson RE, Macor JE, Albright CF.
    J Pharmacol Exp Ther; 2008 Aug 26; 326(2):502-13. PubMed ID: 18499745
    [Abstract] [Full Text] [Related]

  • 9. Nicotine modulates expression of amyloid precursor protein and amyloid precursor-like protein 2 in mouse brain and in SH-SY5Y neuroblastoma cells.
    Gutala R, Wang J, Hwang YY, Haq R, Li MD.
    Brain Res; 2006 Jun 06; 1093(1):12-9. PubMed ID: 16707114
    [Abstract] [Full Text] [Related]

  • 10. Abeta is targeted to the vasculature in a mouse model of hereditary cerebral hemorrhage with amyloidosis.
    Herzig MC, Winkler DT, Burgermeister P, Pfeifer M, Kohler E, Schmidt SD, Danner S, Abramowski D, Stürchler-Pierrat C, Bürki K, van Duinen SG, Maat-Schieman ML, Staufenbiel M, Mathews PM, Jucker M.
    Nat Neurosci; 2004 Sep 06; 7(9):954-60. PubMed ID: 15311281
    [Abstract] [Full Text] [Related]

  • 11. Oral administration of a potent and selective non-peptidic BACE-1 inhibitor decreases beta-cleavage of amyloid precursor protein and amyloid-beta production in vivo.
    Hussain I, Hawkins J, Harrison D, Hille C, Wayne G, Cutler L, Buck T, Walter D, Demont E, Howes C, Naylor A, Jeffrey P, Gonzalez MI, Dingwall C, Michel A, Redshaw S, Davis JB.
    J Neurochem; 2007 Feb 06; 100(3):802-9. PubMed ID: 17156133
    [Abstract] [Full Text] [Related]

  • 12. BACE1 and mutated presenilin-1 differently modulate Abeta40 and Abeta42 levels and cerebral amyloidosis in APPDutch transgenic mice.
    Herzig MC, Paganetti P, Staufenbiel M, Jucker M.
    Neurodegener Dis; 2007 Feb 06; 4(2-3):127-35. PubMed ID: 17596707
    [Abstract] [Full Text] [Related]

  • 13. Targeting ADAM10 to lipid rafts in neuroblastoma SH-SY5Y cells impairs amyloidogenic processing of the amyloid precursor protein.
    Harris B, Pereira I, Parkin E.
    Brain Res; 2009 Nov 03; 1296():203-15. PubMed ID: 19679113
    [Abstract] [Full Text] [Related]

  • 14. Caffeine protects Alzheimer's mice against cognitive impairment and reduces brain beta-amyloid production.
    Arendash GW, Schleif W, Rezai-Zadeh K, Jackson EK, Zacharia LC, Cracchiolo JR, Shippy D, Tan J.
    Neuroscience; 2006 Nov 03; 142(4):941-52. PubMed ID: 16938404
    [Abstract] [Full Text] [Related]

  • 15. Reductions in beta-amyloid concentrations in vivo by the gamma-secretase inhibitors BMS-289948 and BMS-299897.
    Anderson JJ, Holtz G, Baskin PP, Turner M, Rowe B, Wang B, Kounnas MZ, Lamb BT, Barten D, Felsenstein K, McDonald I, Srinivasan K, Munoz B, Wagner SL.
    Biochem Pharmacol; 2005 Feb 15; 69(4):689-98. PubMed ID: 15670587
    [Abstract] [Full Text] [Related]

  • 16. Gamma-secretase subunit composition and distribution in the presenilin wild-type and mutant mouse brain.
    Siman R, Salidas S.
    Neuroscience; 2004 Feb 15; 129(3):615-28. PubMed ID: 15541883
    [Abstract] [Full Text] [Related]

  • 17. BACE1 inhibition reduces endogenous Abeta and alters APP processing in wild-type mice.
    Nishitomi K, Sakaguchi G, Horikoshi Y, Gray AJ, Maeda M, Hirata-Fukae C, Becker AG, Hosono M, Sakaguchi I, Minami SS, Nakajima Y, Li HF, Takeyama C, Kihara T, Ota A, Wong PC, Aisen PS, Kato A, Kinoshita N, Matsuoka Y.
    J Neurochem; 2006 Dec 15; 99(6):1555-63. PubMed ID: 17083447
    [Abstract] [Full Text] [Related]

  • 18. Effect of subchronic treatment of memantine, galantamine, and nicotine in the brain of Tg2576 (APPswe) transgenic mice.
    Unger C, Svedberg MM, Yu WF, Hedberg MM, Nordberg A.
    J Pharmacol Exp Ther; 2006 Apr 15; 317(1):30-6. PubMed ID: 16354790
    [Abstract] [Full Text] [Related]

  • 19. Acute treatment with the PPARgamma agonist pioglitazone and ibuprofen reduces glial inflammation and Abeta1-42 levels in APPV717I transgenic mice.
    Heneka MT, Sastre M, Dumitrescu-Ozimek L, Hanke A, Dewachter I, Kuiperi C, O'Banion K, Klockgether T, Van Leuven F, Landreth GE.
    Brain; 2005 Jun 15; 128(Pt 6):1442-53. PubMed ID: 15817521
    [Abstract] [Full Text] [Related]

  • 20. 1-(3',4'-Dichloro-2-fluoro[1,1'-biphenyl]-4-yl)-cyclopropanecarboxylic acid (CHF5074), a novel gamma-secretase modulator, reduces brain beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease without causing peripheral toxicity.
    Imbimbo BP, Del Giudice E, Colavito D, D'Arrigo A, Dalle Carbonare M, Villetti G, Facchinetti F, Volta R, Pietrini V, Baroc MF, Serneels L, De Strooper B, Leon A.
    J Pharmacol Exp Ther; 2007 Dec 15; 323(3):822-30. PubMed ID: 17895400
    [Abstract] [Full Text] [Related]

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