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688 related items for PubMed ID: 15147316

  • 1. Targeted introduction of V642I mutation in amyloid precursor protein gene causes functional abnormality resembling early stage of Alzheimer's disease in aged mice.
    Kawasumi M, Chiba T, Yamada M, Miyamae-Kaneko M, Matsuoka M, Nakahara J, Tomita T, Iwatsubo T, Kato S, Aiso S, Nishimoto I, Kouyama K.
    Eur J Neurosci; 2004 May; 19(10):2826-38. PubMed ID: 15147316
    [Abstract] [Full Text] [Related]

  • 2. Intraneuronal amyloid beta and reduced brain volume in a novel APP T714I mouse model for Alzheimer's disease.
    Van Broeck B, Vanhoutte G, Pirici D, Van Dam D, Wils H, Cuijt I, Vennekens K, Zabielski M, Michalik A, Theuns J, De Deyn PP, Van der Linden A, Van Broeckhoven C, Kumar-Singh S.
    Neurobiol Aging; 2008 Feb; 29(2):241-52. PubMed ID: 17112635
    [Abstract] [Full Text] [Related]

  • 3. Aberrant expressions of pathogenic phenotype in Alzheimer's diseased transgenic mice carrying NSE-controlled APPsw.
    Hwang DY, Cho JS, Lee SH, Chae KR, Lim HJ, Min SH, Seo SJ, Song YS, Song CW, Paik SG, Sheen YY, Kim YK.
    Exp Neurol; 2004 Mar; 186(1):20-32. PubMed ID: 14980807
    [Abstract] [Full Text] [Related]

  • 4. Progressive cognitive impairment and anxiety induction in the absence of plaque deposition in C57BL/6 inbred mice expressing transgenic amyloid precursor protein.
    Lee KW, Lee SH, Kim H, Song JS, Yang SD, Paik SG, Han PL.
    J Neurosci Res; 2004 May 15; 76(4):572-80. PubMed ID: 15114629
    [Abstract] [Full Text] [Related]

  • 5. Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP.
    Lewis J, Dickson DW, Lin WL, Chisholm L, Corral A, Jones G, Yen SH, Sahara N, Skipper L, Yager D, Eckman C, Hardy J, Hutton M, McGowan E.
    Science; 2001 Aug 24; 293(5534):1487-91. PubMed ID: 11520987
    [Abstract] [Full Text] [Related]

  • 6. Neuropathological characterization of mutant amyloid precursor protein yeast artificial chromosome transgenic mice.
    Kulnane LS, Lamb BT.
    Neurobiol Dis; 2001 Dec 24; 8(6):982-92. PubMed ID: 11741394
    [Abstract] [Full Text] [Related]

  • 7. Central cholinergic functions in human amyloid precursor protein knock-in/presenilin-1 transgenic mice.
    Hartmann J, Erb C, Ebert U, Baumann KH, Popp A, König G, Klein J.
    Neuroscience; 2004 Dec 24; 125(4):1009-17. PubMed ID: 15120860
    [Abstract] [Full Text] [Related]

  • 8. Amyloid plaques, neurofibrillary tangles and neuronal loss in brains of transgenic mice overexpressing a C-terminal fragment of human amyloid precursor protein.
    Kawabata S, Higgins GA, Gordon JW.
    Nature; 1991 Dec 12; 354(6353):476-8. PubMed ID: 1793460
    [Abstract] [Full Text] [Related]

  • 9. Alzheimer-type neuropathology in transgenic mice overexpressing V717F beta-amyloid precursor protein.
    Games D, Adams D, Alessandrini R, Barbour R, Berthelette P, Blackwell C, Carr T, Clemens J, Donaldson T, Gillespie F.
    Nature; 1995 Feb 09; 373(6514):523-7. PubMed ID: 7845465
    [Abstract] [Full Text] [Related]

  • 10. Mutations in amyloid precursor protein and presenilin-1 genes increase the basal oxidative stress in murine neuronal cells and lead to increased sensitivity to oxidative stress mediated by amyloid beta-peptide (1-42), HO and kainic acid: implications for Alzheimer's disease.
    Mohmmad Abdul H, Sultana R, Keller JN, St Clair DK, Markesbery WR, Butterfield DA.
    J Neurochem; 2006 Mar 09; 96(5):1322-35. PubMed ID: 16478525
    [Abstract] [Full Text] [Related]

  • 11. Amyloid precursor protein cytoplasmic domain with phospho-Thr668 accumulates in Alzheimer's disease and its transgenic models: a role to mediate interaction of Abeta and tau.
    Shin RW, Ogino K, Shimabuku A, Taki T, Nakashima H, Ishihara T, Kitamoto T.
    Acta Neuropathol; 2007 Jun 09; 113(6):627-36. PubMed ID: 17431643
    [Abstract] [Full Text] [Related]

  • 12. [Recent advances in Alzheimer's disease research--amyloid precursor protein trafficking, processing, and mutations in Alzheimer's disease linked genes].
    Fukatsu R, Tsuzuki K, Hayashi Y, Takamaru Y, Sasaki N, Yoshida T, Hatakeyama Y, Fuji N, Takahata N.
    Hokkaido Igaku Zasshi; 1997 Jan 09; 72(1):3-11. PubMed ID: 9086357
    [Abstract] [Full Text] [Related]

  • 13. Age-dependent increase in lysosome-associated membrane protein 1 and early-onset behavioral deficits in APPSL transgenic mouse model of Alzheimer's disease.
    Hashimoto T, Ogino K, Shin RW, Kitamoto T, Kikuchi T, Shimizu N.
    Neurosci Lett; 2010 Jan 22; 469(2):273-7. PubMed ID: 20025930
    [Abstract] [Full Text] [Related]

  • 14. Progressive age-related development of Alzheimer-like pathology in APP/PS1 mice.
    Trinchese F, Liu S, Battaglia F, Walter S, Mathews PM, Arancio O.
    Ann Neurol; 2004 Jun 22; 55(6):801-14. PubMed ID: 15174014
    [Abstract] [Full Text] [Related]

  • 15. Deposition of mouse amyloid beta in human APP/PS1 double and single AD model transgenic mice.
    van Groen T, Kiliaan AJ, Kadish I.
    Neurobiol Dis; 2006 Sep 22; 23(3):653-62. PubMed ID: 16829076
    [Abstract] [Full Text] [Related]

  • 16. Beta-amyloid precursor protein transgenic mice that harbor diffuse A beta deposits but do not form plaques show increased ischemic vulnerability: role of inflammation.
    Koistinaho M, Kettunen MI, Goldsteins G, Keinänen R, Salminen A, Ort M, Bures J, Liu D, Kauppinen RA, Higgins LS, Koistinaho J.
    Proc Natl Acad Sci U S A; 2002 Feb 05; 99(3):1610-5. PubMed ID: 11818564
    [Abstract] [Full Text] [Related]

  • 17. Estrogen treatment improves spatial learning in APP + PS1 mice but does not affect beta amyloid accumulation and plaque formation.
    Heikkinen T, Kalesnykas G, Rissanen A, Tapiola T, Iivonen S, Wang J, Chaudhuri J, Tanila H, Miettinen R, Puoliväli J.
    Exp Neurol; 2004 May 05; 187(1):105-17. PubMed ID: 15081593
    [Abstract] [Full Text] [Related]

  • 18. Allele-specific silencing of Alzheimer's disease genes: the amyloid precursor protein genes with Swedish or London mutations.
    Feng X, Zhao P, He Y, Zuo Z.
    Gene; 2006 Apr 12; 371(1):68-74. PubMed ID: 16426772
    [Abstract] [Full Text] [Related]

  • 19. A transgenic rat model of Alzheimer's disease with extracellular Abeta deposition.
    Flood DG, Lin YG, Lang DM, Trusko SP, Hirsch JD, Savage MJ, Scott RW, Howland DS.
    Neurobiol Aging; 2009 Jul 12; 30(7):1078-90. PubMed ID: 18053619
    [Abstract] [Full Text] [Related]

  • 20. Cognitive and physical activity differently modulate disease progression in the amyloid precursor protein (APP)-23 model of Alzheimer's disease.
    Wolf SA, Kronenberg G, Lehmann K, Blankenship A, Overall R, Staufenbiel M, Kempermann G.
    Biol Psychiatry; 2006 Dec 15; 60(12):1314-23. PubMed ID: 16806094
    [Abstract] [Full Text] [Related]

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