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Journal Abstract Search

337 related items for PubMed ID: 15155556

  • 1. Metabolic activation of troglitazone: identification of a reactive metabolite and mechanisms involved.
    He K, Talaat RE, Pool WF, Reily MD, Reed JE, Bridges AJ, Woolf TF.
    Drug Metab Dispos; 2004 Jun; 32(6):639-46. PubMed ID: 15155556
    [Abstract] [Full Text] [Related]

  • 2. Incorporation of an oxygen from water into troglitazone quinone by cytochrome P450 and myeloperoxidase.
    He K, Talaat RE, Woolf TF.
    Drug Metab Dispos; 2004 Apr; 32(4):442-6. PubMed ID: 15039298
    [Abstract] [Full Text] [Related]

  • 3. Electrochemical oxidation of troglitazone: identification and characterization of the major reactive metabolite in liver microsomes.
    Madsen KG, Grönberg G, Skonberg C, Jurva U, Hansen SH, Olsen J.
    Chem Res Toxicol; 2008 Oct; 21(10):2035-41. PubMed ID: 18788755
    [Abstract] [Full Text] [Related]

  • 4. Metabolism of troglitazone in hepatocytes isolated from experimentally induced diabetic rats.
    Meechan AJ, Henderson C, Bates CD, Grant MH, Tettey JN.
    J Pharm Pharmacol; 2006 Oct; 58(10):1359-65. PubMed ID: 17034659
    [Abstract] [Full Text] [Related]

  • 5. Differences in cytochrome P450-mediated biotransformation of 1,2-dichlorobenzene by rat and man: implications for human risk assessment.
    Hissink AM, Oudshoorn MJ, Van Ommen B, Haenen GR, Van Bladeren PJ.
    Chem Res Toxicol; 1996 Dec; 9(8):1249-56. PubMed ID: 8951226
    [Abstract] [Full Text] [Related]

  • 6. Metabolism of the cytochrome P450 mechanism-based inhibitor N-benzyl-1-aminobenzotriazole to products that covalently bind with protein in guinea pig liver and lung microsomes: comparative study with 1-aminobenzotriazole.
    Woodcroft KJ, Webb CD, Yao M, Weedon AC, Bend JR.
    Chem Res Toxicol; 1997 May; 10(5):589-99. PubMed ID: 9168258
    [Abstract] [Full Text] [Related]

  • 7. Enzyme-induction dependent bioactivation of troglitazone and troglitazone quinone in vivo.
    Tettey JN, Maggs JL, Rapeport WG, Pirmohamed M, Park BK.
    Chem Res Toxicol; 2001 Aug; 14(8):965-74. PubMed ID: 11511170
    [Abstract] [Full Text] [Related]

  • 8. Identification of glutathione conjugates of troglitazone in human hepatocytes.
    Prabhu S, Fackett A, Lloyd S, McClellan HA, Terrell CM, Silber PM, Li AP.
    Chem Biol Interact; 2002 Nov 10; 142(1-2):83-97. PubMed ID: 12399157
    [Abstract] [Full Text] [Related]

  • 9. Thiazolidinedione bioactivation: a comparison of the bioactivation potentials of troglitazone, rosiglitazone, and pioglitazone using stable isotope-labeled analogues and liquid chromatography tandem mass spectrometry.
    Alvarez-Sanchez R, Montavon F, Hartung T, Pähler A.
    Chem Res Toxicol; 2006 Aug 10; 19(8):1106-16. PubMed ID: 16918252
    [Abstract] [Full Text] [Related]

  • 10. Studies on the metabolism of troglitazone to reactive intermediates in vitro and in vivo. Evidence for novel biotransformation pathways involving quinone methide formation and thiazolidinedione ring scission.
    Kassahun K, Pearson PG, Tang W, McIntosh I, Leung K, Elmore C, Dean D, Wang R, Doss G, Baillie TA.
    Chem Res Toxicol; 2001 Jan 10; 14(1):62-70. PubMed ID: 11170509
    [Abstract] [Full Text] [Related]

  • 11. Troglitazone quinone formation catalyzed by human and rat CYP3A: an atypical CYP oxidation reaction.
    He K, Woolf TF, Kindt EK, Fielder AE, Talaat RE.
    Biochem Pharmacol; 2001 Jul 15; 62(2):191-8. PubMed ID: 11389877
    [Abstract] [Full Text] [Related]

  • 12. Metabolic activation of diclofenac by human cytochrome P450 3A4: role of 5-hydroxydiclofenac.
    Shen S, Marchick MR, Davis MR, Doss GA, Pohl LR.
    Chem Res Toxicol; 1999 Feb 15; 12(2):214-22. PubMed ID: 10027801
    [Abstract] [Full Text] [Related]

  • 13. NADPH-dependent covalent binding of [3H]paroxetine to human liver microsomes and S-9 fractions: identification of an electrophilic quinone metabolite of paroxetine.
    Zhao SX, Dalvie DK, Kelly JM, Soglia JR, Frederick KS, Smith EB, Obach RS, Kalgutkar AS.
    Chem Res Toxicol; 2007 Nov 15; 20(11):1649-57. PubMed ID: 17907785
    [Abstract] [Full Text] [Related]

  • 14. Studies on cytochrome P-450-mediated bioactivation of diclofenac in rats and in human hepatocytes: identification of glutathione conjugated metabolites.
    Tang W, Stearns RA, Bandiera SM, Zhang Y, Raab C, Braun MP, Dean DC, Pang J, Leung KH, Doss GA, Strauss JR, Kwei GY, Rushmore TH, Chiu SH, Baillie TA.
    Drug Metab Dispos; 1999 Mar 15; 27(3):365-72. PubMed ID: 10064567
    [Abstract] [Full Text] [Related]

  • 15. Metabolism of capsaicin by cytochrome P450 produces novel dehydrogenated metabolites and decreases cytotoxicity to lung and liver cells.
    Reilly CA, Ehlhardt WJ, Jackson DA, Kulanthaivel P, Mutlib AE, Espina RJ, Moody DE, Crouch DJ, Yost GS.
    Chem Res Toxicol; 2003 Mar 15; 16(3):336-49. PubMed ID: 12641434
    [Abstract] [Full Text] [Related]

  • 16. Bioactivation of isothiazoles: minimizing the risk of potential toxicity in drug discovery.
    Teffera Y, Choquette D, Liu J, Colletti AE, Hollis LS, Lin MH, Zhao Z.
    Chem Res Toxicol; 2010 Nov 15; 23(11):1743-52. PubMed ID: 20825217
    [Abstract] [Full Text] [Related]

  • 17. Evidence for the bioactivation of zomepirac and tolmetin by an oxidative pathway: identification of glutathione adducts in vitro in human liver microsomes and in vivo in rats.
    Chen Q, Doss GA, Tung EC, Liu W, Tang YS, Braun MP, Didolkar V, Strauss JR, Wang RW, Stearns RA, Evans DC, Baillie TA, Tang W.
    Drug Metab Dispos; 2006 Jan 15; 34(1):145-51. PubMed ID: 16251255
    [Abstract] [Full Text] [Related]

  • 18. Investigation of the role of the thiazolidinedione ring of troglitazone in inducing hepatotoxicity.
    Saha S, New LS, Ho HK, Chui WK, Chan EC.
    Toxicol Lett; 2010 Feb 01; 192(2):141-9. PubMed ID: 19854250
    [Abstract] [Full Text] [Related]

  • 19. In vitro metabolic activation of thiabendazole via 5-hydroxythiabendazole: identification of a glutathione conjugate of 5-hydroxythiabendazole.
    Dalvie D, Smith E, Deese A, Bowlin S.
    Drug Metab Dispos; 2006 Apr 01; 34(4):709-17. PubMed ID: 16434547
    [Abstract] [Full Text] [Related]

  • 20. Troglitazone thiol adduct formation in human liver microsomes: enzyme kinetics and reaction phenotyping.
    Gan J, Qu Q, He B, Shyu WC, Rodrigues AD, He K.
    Drug Metab Lett; 2008 Aug 01; 2(3):184-9. PubMed ID: 19356091
    [Abstract] [Full Text] [Related]

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