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Journal Abstract Search


337 related items for PubMed ID: 15155556

  • 21. Bioactivation of coumarin in rat olfactory mucosal microsomes: Detection of protein covalent binding and identification of reactive intermediates through analysis of glutathione adducts.
    Zhuo X, Zhao W, Zheng J, Humphreys WG, Shu YZ, Zhu M.
    Chem Biol Interact; 2009 Oct 07; 181(2):227-35. PubMed ID: 19576871
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  • 22. Metabolic activation of the nitroaromatic antiandrogen flutamide by rat and human cytochromes P-450, including forms belonging to the 3A and 1A subfamilies.
    Berson A, Wolf C, Chachaty C, Fisch C, Fau D, Eugene D, Loeper J, Gauthier JC, Beaune P, Pompon D.
    J Pharmacol Exp Ther; 1993 Apr 07; 265(1):366-72. PubMed ID: 8386241
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  • 23. Bioactivation of phenytoin by human cytochrome P450: characterization of the mechanism and targets of covalent adduct formation.
    Munns AJ, De Voss JJ, Hooper WD, Dickinson RG, Gillam EM.
    Chem Res Toxicol; 1997 Sep 07; 10(9):1049-58. PubMed ID: 9305589
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  • 24. Involvement of different human glutathione transferase isoforms in the glutathione conjugation of reactive metabolites of troglitazone.
    Okada R, Maeda K, Nishiyama T, Aoyama S, Tozuka Z, Hiratsuka A, Ikeda T, Kusuhara H, Sugiyama Y.
    Drug Metab Dispos; 2011 Dec 07; 39(12):2290-7. PubMed ID: 21914835
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  • 25. Negative ion tandem mass spectrometry for the detection of glutathione conjugates.
    Dieckhaus CM, Fernández-Metzler CL, King R, Krolikowski PH, Baillie TA.
    Chem Res Toxicol; 2005 Apr 07; 18(4):630-8. PubMed ID: 15833023
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  • 26. A novel bioactivation pathway for 2-[2-(2,6-dichlorophenyl)aminophenyl]ethanoic acid (diclofenac) initiated by cytochrome P450-mediated oxidative decarboxylation.
    Grillo MP, Ma J, Teffera Y, Waldon DJ.
    Drug Metab Dispos; 2008 Sep 07; 36(9):1740-4. PubMed ID: 18541695
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  • 28. Mechanistic studies on the metabolic scission of thiazolidinedione derivatives to acyclic thiols.
    Reddy VB, Karanam BV, Gruber WL, Wallace MA, Vincent SH, Franklin RB, Baillie TA.
    Chem Res Toxicol; 2005 May 07; 18(5):880-8. PubMed ID: 15892582
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  • 32. Bioactivation of phencyclidine in rat and human liver microsomes and recombinant P450 2B enzymes: evidence for the formation of a novel quinone methide intermediate.
    Driscoll JP, Kornecki K, Wolkowski JP, Chupak L, Kalgutkar AS, O'Donnell JP.
    Chem Res Toxicol; 2007 Oct 07; 20(10):1488-97. PubMed ID: 17892269
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  • 34. Effects of benzyl isothiocyanate on rat and human cytochromes P450: identification of metabolites formed by P450 2B1.
    Goosen TC, Mills DE, Hollenberg PF.
    J Pharmacol Exp Ther; 2001 Jan 07; 296(1):198-206. PubMed ID: 11123381
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  • 36. Metabolic activation of a pyrazinone-containing thrombin inhibitor. Evidence for novel biotransformation involving pyrazinone ring oxidation, rearrangement, and covalent binding to proteins.
    Singh R, Silva Elipe MV, Pearson PG, Arison BH, Wong BK, White R, Yu X, Burgey CS, Lin JH, Baillie TA.
    Chem Res Toxicol; 2003 Feb 07; 16(2):198-207. PubMed ID: 12588191
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  • 37. The metabolism and toxicity of furosemide in the Wistar rat and CD-1 mouse: a chemical and biochemical definition of the toxicophore.
    Williams DP, Antoine DJ, Butler PJ, Jones R, Randle L, Payne A, Howard M, Gardner I, Blagg J, Park BK.
    J Pharmacol Exp Ther; 2007 Sep 07; 322(3):1208-20. PubMed ID: 17556636
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  • 38. Prediction of in vivo potential for metabolic activation of drugs into chemically reactive intermediate: correlation of in vitro and in vivo generation of reactive intermediates and in vitro glutathione conjugate formation in rats and humans.
    Masubuchi N, Makino C, Murayama N.
    Chem Res Toxicol; 2007 Mar 07; 20(3):455-64. PubMed ID: 17309281
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  • 39. Bioactivation of 2,3-diaminopyridine-containing bradykinin B1 receptor antagonists: irreversible binding to liver microsomal proteins and formation of glutathione conjugates.
    Tang C, Subramanian R, Kuo Y, Krymgold S, Lu P, Kuduk SD, Ng C, Feng DM, Elmore C, Soli E, Ho J, Bock MG, Baillie TA, Prueksaritanont T.
    Chem Res Toxicol; 2005 Jun 07; 18(6):934-45. PubMed ID: 15962928
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