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485 related items for PubMed ID: 15189355

  • 1. Immature nicastrin stabilizes APH-1 independent of PEN-2 and presenilin: identification of nicastrin mutants that selectively interact with APH-1.
    Shirotani K, Edbauer D, Kostka M, Steiner H, Haass C.
    J Neurochem; 2004 Jun; 89(6):1520-7. PubMed ID: 15189355
    [Abstract] [Full Text] [Related]

  • 2. Length and overall sequence of the PEN-2 C-terminal domain determines its function in the stabilization of presenilin fragments.
    Prokop S, Haass C, Steiner H.
    J Neurochem; 2005 Jul; 94(1):57-62. PubMed ID: 15953349
    [Abstract] [Full Text] [Related]

  • 3. Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane.
    Kaether C, Lammich S, Edbauer D, Ertl M, Rietdorf J, Capell A, Steiner H, Haass C.
    J Cell Biol; 2002 Aug 05; 158(3):551-61. PubMed ID: 12147673
    [Abstract] [Full Text] [Related]

  • 4. Pharmacological evidences for DFK167-sensitive presenilin-independent gamma-secretase-like activity.
    Sevalle J, Ayral E, Hernandez JF, Martinez J, Checler F.
    J Neurochem; 2009 Jul 05; 110(1):275-83. PubMed ID: 19457123
    [Abstract] [Full Text] [Related]

  • 5. Reconstitution of gamma-secretase activity.
    Edbauer D, Winkler E, Regula JT, Pesold B, Steiner H, Haass C.
    Nat Cell Biol; 2003 May 05; 5(5):486-8. PubMed ID: 12679784
    [Abstract] [Full Text] [Related]

  • 6. Detergent-dependent dissociation of active gamma-secretase reveals an interaction between Pen-2 and PS1-NTF and offers a model for subunit organization within the complex.
    Fraering PC, LaVoie MJ, Ye W, Ostaszewski BL, Kimberly WT, Selkoe DJ, Wolfe MS.
    Biochemistry; 2004 Jan 20; 43(2):323-33. PubMed ID: 14717586
    [Abstract] [Full Text] [Related]

  • 7. PEN-2 enhances gamma-cleavage after presenilin heterodimer formation.
    Shiraishi H, Sai X, Wang HQ, Maeda Y, Kurono Y, Nishimura M, Yanagisawa K, Komano H.
    J Neurochem; 2004 Sep 20; 90(6):1402-13. PubMed ID: 15341524
    [Abstract] [Full Text] [Related]

  • 8. The role of presenilin cofactors in the gamma-secretase complex.
    Takasugi N, Tomita T, Hayashi I, Tsuruoka M, Niimura M, Takahashi Y, Thinakaran G, Iwatsubo T.
    Nature; 2003 Mar 27; 422(6930):438-41. PubMed ID: 12660785
    [Abstract] [Full Text] [Related]

  • 9. Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation.
    Edbauer D, Winkler E, Haass C, Steiner H.
    Proc Natl Acad Sci U S A; 2002 Jun 25; 99(13):8666-71. PubMed ID: 12048259
    [Abstract] [Full Text] [Related]

  • 10. Conserved residues in juxtamembrane region of the extracellular domain of nicastrin are essential for gamma-secretase complex formation.
    Walker ES, Martinez M, Wang J, Goate A.
    J Neurochem; 2006 Jul 25; 98(1):300-9. PubMed ID: 16805816
    [Abstract] [Full Text] [Related]

  • 11. Excess of nicastrin in brain results in heterozygosity having no effect on endogenous APP processing and amyloid peptide levels in vivo.
    Brijbassi S, Amtul Z, Newbigging S, Westaway D, St George-Hyslop P, Rozmahel RF.
    Neurobiol Dis; 2007 Feb 25; 25(2):291-6. PubMed ID: 17071095
    [Abstract] [Full Text] [Related]

  • 12. Nicastrin is critical for stability and trafficking but not association of other presenilin/gamma-secretase components.
    Zhang YW, Luo WJ, Wang H, Lin P, Vetrivel KS, Liao F, Li F, Wong PC, Farquhar MG, Thinakaran G, Xu H.
    J Biol Chem; 2005 Apr 29; 280(17):17020-6. PubMed ID: 15711015
    [Abstract] [Full Text] [Related]

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  • 15. Reconstitution of gamma-secretase by truncated presenilin (PS) fragments revealed that PS C-terminal transmembrane domain is critical for formation of gamma-secretase complex.
    Shiraishi H, Marutani T, Wang HQ, Maeda Y, Kurono Y, Takashima A, Araki W, Nishimura M, Yanagisawa K, Komano H.
    Genes Cells; 2006 Jan 29; 11(1):83-93. PubMed ID: 16371134
    [Abstract] [Full Text] [Related]

  • 16. Ubiquitin-proteasome pathway mediates degradation of APH-1.
    He G, Qing H, Cai F, Kwok C, Xu H, Yu G, Bernstein A, Song W.
    J Neurochem; 2006 Dec 29; 99(5):1403-12. PubMed ID: 17059559
    [Abstract] [Full Text] [Related]

  • 17. Pathological activity of familial Alzheimer's disease-associated mutant presenilin can be executed by six different gamma-secretase complexes.
    Shirotani K, Tomioka M, Kremmer E, Haass C, Steiner H.
    Neurobiol Dis; 2007 Jul 29; 27(1):102-7. PubMed ID: 17560791
    [Abstract] [Full Text] [Related]

  • 18. The Alzheimer's disease-associated gamma-secretase complex: functional domains in the presenilin 1 protein.
    Laudon H, Winblad B, Näslund J.
    Physiol Behav; 2007 Sep 10; 92(1-2):115-20. PubMed ID: 17588625
    [Abstract] [Full Text] [Related]

  • 19. Assembly, trafficking and function of gamma-secretase.
    Kaether C, Haass C, Steiner H.
    Neurodegener Dis; 2006 Sep 10; 3(4-5):275-83. PubMed ID: 17047368
    [Abstract] [Full Text] [Related]

  • 20. gamma-Secretase complexes containing N- and C-terminal fragments of different presenilin origin retain normal gamma-secretase activity.
    Strömberg K, Hansson EM, Laudon H, Bergstedt S, Näslund J, Lundkvist J, Lendahl U.
    J Neurochem; 2005 Nov 10; 95(3):880-90. PubMed ID: 16135086
    [Abstract] [Full Text] [Related]

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