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369 related items for PubMed ID: 15208673

  • 1. AKT and mTOR phosphorylation is frequently detected in ovarian cancer and can be targeted to disrupt ovarian tumor cell growth.
    Altomare DA, Wang HQ, Skele KL, De Rienzo A, Klein-Szanto AJ, Godwin AK, Testa JR.
    Oncogene; 2004 Jul 29; 23(34):5853-7. PubMed ID: 15208673
    [Abstract] [Full Text] [Related]

  • 2. G1 cell cycle progression and the expression of G1 cyclins are regulated by PI3K/AKT/mTOR/p70S6K1 signaling in human ovarian cancer cells.
    Gao N, Flynn DC, Zhang Z, Zhong XS, Walker V, Liu KJ, Shi X, Jiang BH.
    Am J Physiol Cell Physiol; 2004 Aug 29; 287(2):C281-91. PubMed ID: 15028555
    [Abstract] [Full Text] [Related]

  • 3. Positive feedback regulation between AKT activation and fatty acid synthase expression in ovarian carcinoma cells.
    Wang HQ, Altomare DA, Skele KL, Poulikakos PI, Kuhajda FP, Di Cristofano A, Testa JR.
    Oncogene; 2005 May 19; 24(22):3574-82. PubMed ID: 15806173
    [Abstract] [Full Text] [Related]

  • 4. Longitudinal inhibition of PI3K/Akt/mTOR signaling by LY294002 and rapamycin induces growth arrest of adult T-cell leukemia cells.
    Ikezoe T, Nishioka C, Bandobashi K, Yang Y, Kuwayama Y, Adachi Y, Takeuchi T, Koeffler HP, Taguchi H.
    Leuk Res; 2007 May 19; 31(5):673-82. PubMed ID: 17007924
    [Abstract] [Full Text] [Related]

  • 5. LY294002 and metformin cooperatively enhance the inhibition of growth and the induction of apoptosis of ovarian cancer cells.
    Li C, Liu VW, Chan DW, Yao KM, Ngan HY.
    Int J Gynecol Cancer; 2012 Jan 19; 22(1):15-22. PubMed ID: 22080879
    [Abstract] [Full Text] [Related]

  • 6. Activation of mammalian target of rapamycin signaling pathway contributes to tumor cell survival in anaplastic lymphoma kinase-positive anaplastic large cell lymphoma.
    Vega F, Medeiros LJ, Leventaki V, Atwell C, Cho-Vega JH, Tian L, Claret FX, Rassidakis GZ.
    Cancer Res; 2006 Jul 01; 66(13):6589-97. PubMed ID: 16818631
    [Abstract] [Full Text] [Related]

  • 7. Activation of Akt and eIF4E survival pathways by rapamycin-mediated mammalian target of rapamycin inhibition.
    Sun SY, Rosenberg LM, Wang X, Zhou Z, Yue P, Fu H, Khuri FR.
    Cancer Res; 2005 Aug 15; 65(16):7052-8. PubMed ID: 16103051
    [Abstract] [Full Text] [Related]

  • 8. Human and mouse mesotheliomas exhibit elevated AKT/PKB activity, which can be targeted pharmacologically to inhibit tumor cell growth.
    Altomare DA, You H, Xiao GH, Ramos-Nino ME, Skele KL, De Rienzo A, Jhanwar SC, Mossman BT, Kane AB, Testa JR.
    Oncogene; 2005 Sep 08; 24(40):6080-9. PubMed ID: 15897870
    [Abstract] [Full Text] [Related]

  • 9. XIAP regulates Akt activity and caspase-3-dependent cleavage during cisplatin-induced apoptosis in human ovarian epithelial cancer cells.
    Asselin E, Mills GB, Tsang BK.
    Cancer Res; 2001 Mar 01; 61(5):1862-8. PubMed ID: 11280739
    [Abstract] [Full Text] [Related]

  • 10. Constitutive activation of phosphatidyl-inositide 3 kinase contributes to the survival of Hodgkin's lymphoma cells through a mechanism involving Akt kinase and mTOR.
    Dutton A, Reynolds GM, Dawson CW, Young LS, Murray PG.
    J Pathol; 2005 Mar 01; 205(4):498-506. PubMed ID: 15714459
    [Abstract] [Full Text] [Related]

  • 11. Frequent activation of AKT2 and induction of apoptosis by inhibition of phosphoinositide-3-OH kinase/Akt pathway in human ovarian cancer.
    Yuan ZQ, Sun M, Feldman RI, Wang G, Ma X, Jiang C, Coppola D, Nicosia SV, Cheng JQ.
    Oncogene; 2000 May 04; 19(19):2324-30. PubMed ID: 10822383
    [Abstract] [Full Text] [Related]

  • 12. Inhibition of the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin pathway but not the MEK/ERK pathway attenuates laminin-mediated small cell lung cancer cellular survival and resistance to imatinib mesylate or chemotherapy.
    Tsurutani J, West KA, Sayyah J, Gills JJ, Dennis PA.
    Cancer Res; 2005 Sep 15; 65(18):8423-32. PubMed ID: 16166321
    [Abstract] [Full Text] [Related]

  • 13. Synergistic augmentation of rapamycin-induced autophagy in malignant glioma cells by phosphatidylinositol 3-kinase/protein kinase B inhibitors.
    Takeuchi H, Kondo Y, Fujiwara K, Kanzawa T, Aoki H, Mills GB, Kondo S.
    Cancer Res; 2005 Apr 15; 65(8):3336-46. PubMed ID: 15833867
    [Abstract] [Full Text] [Related]

  • 14. Signal transduction pathways in androgen-dependent and -independent prostate cancer cell proliferation.
    Ghosh PM, Malik SN, Bedolla RG, Wang Y, Mikhailova M, Prihoda TJ, Troyer DA, Kreisberg JI.
    Endocr Relat Cancer; 2005 Mar 15; 12(1):119-34. PubMed ID: 15788644
    [Abstract] [Full Text] [Related]

  • 15. Activation of PI3K/Akt pathway by PTEN reduction and PIK3CA mRNA amplification contributes to cisplatin resistance in an ovarian cancer cell line.
    Lee S, Choi EJ, Jin C, Kim DH.
    Gynecol Oncol; 2005 Apr 15; 97(1):26-34. PubMed ID: 15790433
    [Abstract] [Full Text] [Related]

  • 16. Cisplatin and PI3kinase inhibition decrease invasion and migration of human ovarian carcinoma cells and regulate matrix-metalloproteinase expression.
    Karam AK, Santiskulvong C, Fekete M, Zabih S, Eng C, Dorigo O.
    Cytoskeleton (Hoboken); 2010 Aug 15; 67(8):535-44. PubMed ID: 20607860
    [Abstract] [Full Text] [Related]

  • 17. Inhibition of mTOR activity restores tamoxifen response in breast cancer cells with aberrant Akt Activity.
    deGraffenried LA, Friedrichs WE, Russell DH, Donzis EJ, Middleton AK, Silva JM, Roth RA, Hidalgo M.
    Clin Cancer Res; 2004 Dec 01; 10(23):8059-67. PubMed ID: 15585641
    [Abstract] [Full Text] [Related]

  • 18. PKB/Akt mediates radiosensitization by the signaling inhibitor LY294002 in human malignant gliomas.
    Nakamura JL, Karlsson A, Arvold ND, Gottschalk AR, Pieper RO, Stokoe D, Haas-Kogan DA.
    J Neurooncol; 2005 Feb 01; 71(3):215-22. PubMed ID: 15735908
    [Abstract] [Full Text] [Related]

  • 19. Role of the Akt/mTOR survival pathway in cisplatin resistance in ovarian cancer cells.
    Peng DJ, Wang J, Zhou JY, Wu GS.
    Biochem Biophys Res Commun; 2010 Apr 09; 394(3):600-5. PubMed ID: 20214883
    [Abstract] [Full Text] [Related]

  • 20. The in vitro and in vivo effects of 2-(4-morpholinyl)-8-phenyl-chromone (LY294002), a specific inhibitor of phosphatidylinositol 3'-kinase, in human colon cancer cells.
    Semba S, Itoh N, Ito M, Harada M, Yamakawa M.
    Clin Cancer Res; 2002 Jun 09; 8(6):1957-63. PubMed ID: 12060641
    [Abstract] [Full Text] [Related]

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