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325 related items for PubMed ID: 15220194

  • 1. Glucose- and interleukin-1beta-induced beta-cell apoptosis requires Ca2+ influx and extracellular signal-regulated kinase (ERK) 1/2 activation and is prevented by a sulfonylurea receptor 1/inwardly rectifying K+ channel 6.2 (SUR/Kir6.2) selective potassium channel opener in human islets.
    Maedler K, Størling J, Sturis J, Zuellig RA, Spinas GA, Arkhammar PO, Mandrup-Poulsen T, Donath MY.
    Diabetes; 2004 Jul; 53(7):1706-13. PubMed ID: 15220194
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  • 2. Potent and selective activation of the pancreatic beta-cell type K(ATP) channel by two novel diazoxide analogues.
    Dabrowski M, Larsen T, Ashcroft FM, Bondo Hansen J, Wahl P.
    Diabetologia; 2003 Oct; 46(10):1375-82. PubMed ID: 12961066
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  • 3. Induction of beta-cell rest by a Kir6.2/SUR1-selective K(ATP)-channel opener preserves beta-cell insulin stores and insulin secretion in human islets cultured at high (11 mM) glucose.
    Ritzel RA, Hansen JB, Veldhuis JD, Butler PC.
    J Clin Endocrinol Metab; 2004 Feb; 89(2):795-805. PubMed ID: 14764798
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  • 4. The effects of NN414, a SUR1/Kir6.2 selective potassium channel opener, in healthy male subjects.
    Zdravkovic M, Kruse M, Rost KL, Møss J, Kecskes A, Dyrberg T.
    J Clin Pharmacol; 2005 Jul; 45(7):763-72. PubMed ID: 15951466
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  • 5. NN414, a SUR1/Kir6.2-selective potassium channel opener, reduces blood glucose and improves glucose tolerance in the VDF Zucker rat.
    Carr RD, Brand CL, Bodvarsdottir TB, Hansen JB, Sturis J.
    Diabetes; 2003 Oct; 52(10):2513-8. PubMed ID: 14514634
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  • 6. Requirements of calcium fluxes and ERK kinase activation for glucose- and interleukin-1beta-induced beta-cell apoptosis.
    Fei H, Zhao B, Zhao S, Wang Q.
    Mol Cell Biochem; 2008 Aug; 315(1-2):75-84. PubMed ID: 18498041
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  • 7. Attenuation of hyperinsulinemia by NN414, a SUR1/Kir6.2 selective K-adenosine triphosphate channel opener, improves glucose tolerance and lipid profile in obese Zucker rats.
    Alemzadeh R, Fledelius C, Bodvarsdottir T, Sturis J.
    Metabolism; 2004 Apr; 53(4):441-7. PubMed ID: 15045689
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  • 9. A novel enhancer of insulinotrophic action by high glucose (JTT-608) stimulates insulin secretion from pancreatic beta-cells via a new cellular mechanism.
    Itabashi N, Okada K, Muto S, Fujita N, Ohta T, Miyazaki Ji, Asano Y, Saito T.
    J Pharmacol Exp Ther; 2001 Jun; 297(3):953-60. PubMed ID: 11356916
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  • 10. Possible New Strategies for the Treatment of Congenital Hyperinsulinism.
    Sikimic J, Hoffmeister T, Gresch A, Kaiser J, Barthlen W, Wolke C, Wieland I, Lendeckel U, Krippeit-Drews P, Düfer M, Drews G.
    Front Endocrinol (Lausanne); 2020 Jun; 11():545638. PubMed ID: 33193079
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  • 11. Towards selective Kir6.2/SUR1 potassium channel openers, medicinal chemistry and therapeutic perspectives.
    Hansen JB.
    Curr Med Chem; 2006 Jun; 13(4):361-76. PubMed ID: 16475928
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  • 14. Protection of rat pancreatic islets by potassium channel openers against alloxan, sodium nitroprusside and interleukin-1beta mediated suppression--possible involvement of the mitochondrial membrane potential.
    Kullin M, Li Z, Bondo Hansen J, Welsh N, Karlsson FA, Sandler S.
    Diabetologia; 2003 Jan; 46(1):80-8. PubMed ID: 12637986
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  • 15. The actions of a novel potent islet beta-cell specific ATP-sensitive K+ channel opener can be modulated by syntaxin-1A acting on sulfonylurea receptor 1.
    Ng B, Kang Y, Elias CL, He Y, Xie H, Hansen JB, Wahl P, Gaisano HY.
    Diabetes; 2007 Aug; 56(8):2124-34. PubMed ID: 17496234
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  • 19. The effects of NN414, a SUR1/Kir6.2 selective potassium channel opener in subjects with type 2 diabetes.
    Zdravkovic M, Kruse M, Rost KL, Møss J, Kecskes A.
    Exp Clin Endocrinol Diabetes; 2007 Jun; 115(6):405-6. PubMed ID: 17701889
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  • 20. Regulated expression of adenosine triphosphate-sensitive potassium channel subunits in pancreatic beta-cells.
    Moritz W, Leech CA, Ferrer J, Habener JF.
    Endocrinology; 2001 Jan; 142(1):129-38. PubMed ID: 11145575
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