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Journal Abstract Search

210 related items for PubMed ID: 1522596

  • 1. Active site of trypanothione reductase. A target for rational drug design.
    Hunter WN, Bailey S, Habash J, Harrop SJ, Helliwell JR, Aboagye-Kwarteng T, Smith K, Fairlamb AH.
    J Mol Biol; 1992 Sep 05; 227(1):322-33. PubMed ID: 1522596
    [Abstract] [Full Text] [Related]

  • 2. Substrate interactions between trypanothione reductase and N1-glutathionylspermidine disulphide at 0.28-nm resolution.
    Bailey S, Smith K, Fairlamb AH, Hunter WN.
    Eur J Biochem; 1993 Apr 01; 213(1):67-75. PubMed ID: 8477734
    [Abstract] [Full Text] [Related]

  • 3. Redox enzyme engineering: conversion of human glutathione reductase into a trypanothione reductase.
    Bradley M, Bücheler US, Walsh CT.
    Biochemistry; 1991 Jun 25; 30(25):6124-7. PubMed ID: 2059620
    [Abstract] [Full Text] [Related]

  • 4. Molecular studies on trypanothione reductase: an antiparasitic target enzyme.
    Walsh C, Bradley M, Nadeau K.
    Curr Top Cell Regul; 1992 Jun 25; 33():409-17. PubMed ID: 1354149
    [No Abstract] [Full Text] [Related]

  • 5. Engineering the substrate specificity of glutathione reductase toward that of trypanothione reduction.
    Henderson GB, Murgolo NJ, Kuriyan J, Osapay K, Kominos D, Berry A, Scrutton NS, Hinchliffe NW, Perham RN, Cerami A.
    Proc Natl Acad Sci U S A; 1991 Oct 01; 88(19):8769-73. PubMed ID: 1924337
    [Abstract] [Full Text] [Related]

  • 6. X-ray structure of trypanothione reductase from Crithidia fasciculata at 2.4-A resolution.
    Kuriyan J, Kong XP, Krishna TS, Sweet RM, Murgolo NJ, Field H, Cerami A, Henderson GB.
    Proc Natl Acad Sci U S A; 1991 Oct 01; 88(19):8764-8. PubMed ID: 1924336
    [Abstract] [Full Text] [Related]

  • 7. Crystal structure of Trypanosoma cruzi trypanothione reductase in complex with trypanothione, and the structure-based discovery of new natural product inhibitors.
    Bond CS, Zhang Y, Berriman M, Cunningham ML, Fairlamb AH, Hunter WN.
    Structure; 1999 Jan 15; 7(1):81-9. PubMed ID: 10368274
    [Abstract] [Full Text] [Related]

  • 8. Glutathione reductase turned into trypanothione reductase: structural analysis of an engineered change in substrate specificity.
    Stoll VS, Simpson SJ, Krauth-Siegel RL, Walsh CT, Pai EF.
    Biochemistry; 1997 May 27; 36(21):6437-47. PubMed ID: 9174360
    [Abstract] [Full Text] [Related]

  • 9. The glutamyl binding site of trypanothione reductase from Crithidia fasciculata: enzyme kinetic properties of gamma-glutamyl-modified substrate analogues.
    el-Waer AF, Smith K, McKie JH, Benson T, Fairlamb AH, Douglas KT.
    Biochim Biophys Acta; 1993 Nov 10; 1203(1):93-8. PubMed ID: 8105896
    [Abstract] [Full Text] [Related]

  • 10. Molecular characterization of the trypanothione reductase gene from Crithidia fasciculata and Trypanosoma brucei: comparison with other flavoprotein disulphide oxidoreductases with respect to substrate specificity and catalytic mechanism.
    Aboagye-Kwarteng T, Smith K, Fairlamb AH.
    Mol Microbiol; 1992 Nov 10; 6(21):3089-99. PubMed ID: 1453951
    [Abstract] [Full Text] [Related]

  • 11. Mutational analysis of parasite trypanothione reductase: acquisition of glutathione reductase activity in a triple mutant.
    Sullivan FX, Sobolov SB, Bradley M, Walsh CT.
    Biochemistry; 1991 Mar 19; 30(11):2761-7. PubMed ID: 2007114
    [Abstract] [Full Text] [Related]

  • 12. Trypanothione: a novel bis(glutathionyl)spermidine cofactor for glutathione reductase in trypanosomatids.
    Fairlamb AH, Blackburn P, Ulrich P, Chait BT, Cerami A.
    Science; 1985 Mar 22; 227(4693):1485-7. PubMed ID: 3883489
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  • 17. Cloning, expression and reconstitution of the trypanothione-dependent peroxidase system of Crithidia fasciculata.
    Tetaud E, Fairlamb AH.
    Mol Biochem Parasitol; 1998 Oct 30; 96(1-2):111-23. PubMed ID: 9851611
    [Abstract] [Full Text] [Related]

  • 18. Structure of trypanothione reductase from Crithidia fasciculata at 2.6 A resolution; enzyme-NADP interactions at 2.8 A resolution.
    Bailey S, Fairlamb AH, Hunter WN.
    Acta Crystallogr D Biol Crystallogr; 1994 Mar 01; 50(Pt 2):139-54. PubMed ID: 15299452
    [Abstract] [Full Text] [Related]

  • 19. Mechanism of inhibition of trypanothione reductase and glutathione reductase by trivalent organic arsenicals.
    Cunningham ML, Zvelebil MJ, Fairlamb AH.
    Eur J Biochem; 1994 Apr 01; 221(1):285-95. PubMed ID: 8168518
    [Abstract] [Full Text] [Related]

  • 20. The structure of Trypanosoma cruzi trypanothione reductase in the oxidized and NADPH reduced state.
    Lantwin CB, Schlichting I, Kabsch W, Pai EF, Krauth-Siegel RL.
    Proteins; 1994 Feb 01; 18(2):161-73. PubMed ID: 8159665
    [Abstract] [Full Text] [Related]

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