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Journal Abstract Search

272 related items for PubMed ID: 15239661

  • 1. Studies toward the discovery of the next generation of antidepressants. 3. Dual 5-HT1A and serotonin transporter affinity within a class of N-aryloxyethylindolylalkylamines.
    Mewshaw RE, Zhou D, Zhou P, Shi X, Hornby G, Spangler T, Scerni R, Smith D, Schechter LE, Andree TH.
    J Med Chem; 2004 Jul 15; 47(15):3823-42. PubMed ID: 15239661
    [Abstract] [Full Text] [Related]

  • 2. Studies toward the discovery of the next generation of antidepressants. Part 6: Dual 5-HT1A receptor and serotonin transporter affinity within a class of arylpiperazinyl-cyclohexyl indole derivatives.
    Zhou D, Zhou P, Evrard DA, Meagher K, Webb M, Harrison BL, Huryn DM, Golembieski J, Hornby GA, Schechter LE, Smith DL, Andree TH, Mewshaw RE.
    Bioorg Med Chem; 2008 Jul 15; 16(14):6707-23. PubMed ID: 18571421
    [Abstract] [Full Text] [Related]

  • 3. Studies toward the discovery of the next generation of antidepressants. Part 5: 3,4-Dihydro-2H-benzo[1,4]oxazine derivatives with dual 5-HT1A receptor and serotonin transporter affinity.
    Zhou D, Harrison BL, Shah U, Andree TH, Hornby GA, Scerni R, Schechter LE, Smith DL, Sullivan KM, Mewshaw RE.
    Bioorg Med Chem Lett; 2006 Mar 01; 16(5):1338-41. PubMed ID: 16332439
    [Abstract] [Full Text] [Related]

  • 4. New arylpiperazine 5-HT(1A) receptor ligands containing the pyrimido[2,1-f]purine fragment: synthesis, in vitro, and in vivo pharmacological evaluation.
    Jurczyk S, Kołaczkowski M, Maryniak E, Zajdel P, Pawłowski M, Tatarczyńska E, Kłodzińska A, Chojnacka-Wójcik E, Bojarski AJ, Charakchieva-Minol S, Duszyńska B, Nowak G, Maciag D.
    J Med Chem; 2004 May 06; 47(10):2659-66. PubMed ID: 15115407
    [Abstract] [Full Text] [Related]

  • 5. Synthesis and 5-HT(1A), 5-HT(2A) receptor activity of new beta-tetralonohydantoins.
    Byrtus H, Pawłowski M, Czopek A, Bojarski AJ, Duszyńska B, Nowak G, Kłodzińska A, Tatarczyńska E, Wesołowska A, Chojnacka-Wójcik E.
    Eur J Med Chem; 2005 Aug 06; 40(8):820-9. PubMed ID: 16122584
    [Abstract] [Full Text] [Related]

  • 6. Optimization of (arylpiperazinylbutyl)oxindoles exhibiting selective 5-HT₇ receptor antagonist activity.
    Volk B, Gacsályi I, Pallagi K, Poszávácz L, Gyönös I, Szabó E, Bakó T, Spedding M, Simig G, Szénási G.
    J Med Chem; 2011 Oct 13; 54(19):6657-69. PubMed ID: 21859099
    [Abstract] [Full Text] [Related]

  • 7. Synthesis of new serotonin 5-HT7 receptor ligands. Determinants of 5-HT7/5-HT1A receptor selectivity.
    Medina RA, Sallander J, Benhamú B, Porras E, Campillo M, Pardo L, López-Rodríguez ML.
    J Med Chem; 2009 Apr 23; 52(8):2384-92. PubMed ID: 19326916
    [Abstract] [Full Text] [Related]

  • 8. New 1-aryl-3-(4-arylpiperazin-1-yl)propane derivatives, with dual action at 5-HT1A serotonin receptors and serotonin transporter, as a new class of antidepressants.
    Martínez-Esparza J, Oficialdegui AM, Pérez-Silanes S, Heras B, Orús L, Palop JA, Lasheras B, Roca J, Mourelle M, Bosch A, Del Castillo JC, Tordera R, Del Río J, Monge A.
    J Med Chem; 2001 Feb 01; 44(3):418-28. PubMed ID: 11462981
    [Abstract] [Full Text] [Related]

  • 9. Synthesis and SAR of highly potent dual 5-HT1A and 5-HT1B antagonists as potential antidepressant drugs.
    Kling A, Lange UE, Mack H, Bakker MH, Drescher KU, Hornberger W, Hutchins CW, Möller A, Müller R, Schmidt M, Unger L, Wicke K, Schellhaas K, Steiner G.
    Bioorg Med Chem Lett; 2005 Dec 15; 15(24):5567-73. PubMed ID: 16219465
    [Abstract] [Full Text] [Related]

  • 10. 1-Aryl-4-(4-succinimidobutyl)piperazines and their conformationally constrained analogues: synthesis, binding to serotonin (5-HT1A, 5-HT2A, 5-HT7), alpha1-adrenergic, and dopaminergic D2 receptors, and in vivo 5-HT1A functional characteristics.
    Bojarski AJ, Paluchowska MH, Duszyńska B, Kłodzińska A, Tatarczyńska E, Chojnacka-Wójcik E.
    Bioorg Med Chem; 2005 Mar 15; 13(6):2293-303. PubMed ID: 15727878
    [Abstract] [Full Text] [Related]

  • 11. Novel class of arylpiperazines containing N-acylated amino acids: their synthesis, 5-HT1A, 5-HT2A receptor affinity, and in vivo pharmacological evaluation.
    Zajdel P, Subra G, Bojarski AJ, Duszyńska B, Tatarczyńska E, Nikiforuk A, Chojnacka-Wójcik E, Pawłowski M, Martinez J.
    Bioorg Med Chem; 2007 Apr 15; 15(8):2907-19. PubMed ID: 17321139
    [Abstract] [Full Text] [Related]

  • 12. Synthesis and structure-affinity relationship investigations of 5-heteroaryl-substituted analogues of the antipsychotic sertindole. A new class of highly selective alpha(1) adrenoceptor antagonists.
    Balle T, Perregaard J, Ramirez MT, Larsen AK, Søby KK, Liljefors T, Andersen K.
    J Med Chem; 2003 Jan 16; 46(2):265-83. PubMed ID: 12519065
    [Abstract] [Full Text] [Related]

  • 13. Wheel running alters serotonin (5-HT) transporter, 5-HT1A, 5-HT1B, and alpha 1b-adrenergic receptor mRNA in the rat raphe nuclei.
    Greenwood BN, Foley TE, Day HE, Burhans D, Brooks L, Campeau S, Fleshner M.
    Biol Psychiatry; 2005 Mar 01; 57(5):559-68. PubMed ID: 15737672
    [Abstract] [Full Text] [Related]

  • 14. Syntheses and binding studies of new [(aryl)(aryloxy)methyl]piperidine derivatives and related compounds as potential antidepressant drugs with high affinity for serotonin (5-HT) and norepinephrine (NE) transporters.
    Orjales A, Mosquera R, Toledo A, Pumar MC, García N, Cortizo L, Labeaga L, Innerárity A.
    J Med Chem; 2003 Dec 04; 46(25):5512-32. PubMed ID: 14640559
    [Abstract] [Full Text] [Related]

  • 15. Design and synthesis of long-chain arylpiperazines with mixed affinity for serotonin transporter (SERT) and 5-HT(1A) receptor.
    Perrone R, Berardi F, Colabufo NA, Lacivita E, Larizza C, Leopoldo M, Tortorella V.
    J Pharm Pharmacol; 2005 Oct 04; 57(10):1319-27. PubMed ID: 16259761
    [Abstract] [Full Text] [Related]

  • 16. New 3-[4-(aryl)piperazin-1-yl]-1-(benzo[b]thiophen-2-yl)propane derivatives with dual action at 5-HT1A serotonin receptors and serotonin transporter as a new class of antidepressants.
    Orús L, Sáinz Y, Pérez S, Oficialdegui AM, Martinez J, Lasheras B, del Río J, Monge A.
    Pharmazie; 2002 Jun 04; 57(6):355-7. PubMed ID: 12116869
    [Abstract] [Full Text] [Related]

  • 17. 3-[(Aryl)(4-fluorobenzyloxy)methyl]piperidine derivatives: high-affinity ligands for the serotonin transporter.
    Nencetti S, Demontis GC, Mazzoni MR, Betti L, Banti I, Rossello A, Lapucci A.
    J Pharm Pharmacol; 2007 Oct 04; 59(10):1439-45. PubMed ID: 17910821
    [Abstract] [Full Text] [Related]

  • 18. New 3-[4-(3-substituted phenyl)piperazin-1-yl]-1-(benzo[b]thiophen-3-yl)propanol derivatives with dual action at 5-HT1A serotonin receptors and serotonin transporter as a new class of antidepressants.
    Orús L, Martínez J, Pérez S, Oficialdegui AM, del Castillo JC, Mourelle M, Lasheras B, del Río J, Monge A.
    Pharmazie; 2002 Aug 04; 57(8):515-8. PubMed ID: 12227188
    [Abstract] [Full Text] [Related]

  • 19. Novel mannich bases, 5-arylimidazolidine-2,4-dione derivatives with dual 5-HT(1A) receptor and serotonin transporter affinity.
    Czopek A, Kołaczkowski M, Bucki A, Byrtus H, Pawłowski M, Siwek A, Bojarski AJ, Bednarski M, Wróbel D, Wesołowska A.
    Arch Pharm (Weinheim); 2013 Feb 04; 346(2):98-109. PubMed ID: 23288448
    [Abstract] [Full Text] [Related]

  • 20. Structure-affinity relationship study on N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinealkylamides, a new class of 5-hydroxytryptamine7 receptor agents.
    Leopoldo M, Berardi F, Colabufo NA, Contino M, Lacivita E, Niso M, Perrone R, Tortorella V.
    J Med Chem; 2004 Dec 16; 47(26):6616-24. PubMed ID: 15588097
    [Abstract] [Full Text] [Related]

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