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313 related items for PubMed ID: 15246822

  • 1. The presenilin-1 familial Alzheimer disease mutant P117L impairs neurogenesis in the hippocampus of adult mice.
    Wen PH, Hof PR, Chen X, Gluck K, Austin G, Younkin SG, Younkin LH, DeGasperi R, Gama Sosa MA, Robakis NK, Haroutunian V, Elder GA.
    Exp Neurol; 2004 Aug; 188(2):224-37. PubMed ID: 15246822
    [Abstract] [Full Text] [Related]

  • 2. Overexpression of wild type but not an FAD mutant presenilin-1 promotes neurogenesis in the hippocampus of adult mice.
    Wen PH, Shao X, Shao Z, Hof PR, Wisniewski T, Kelley K, Friedrich VL, Ho L, Pasinetti GM, Shioi J, Robakis NK, Elder GA.
    Neurobiol Dis; 2002 Jun; 10(1):8-19. PubMed ID: 12079399
    [Abstract] [Full Text] [Related]

  • 3. Expression of familial Alzheimer's disease-linked human presenilin 1 variants impair enrichment-induced adult hippocampal neurogenesis.
    Veeraraghavalu K, Choi SH, Sisodia SS.
    Neurodegener Dis; 2010 Jun; 7(1-3):46-9. PubMed ID: 20160458
    [Abstract] [Full Text] [Related]

  • 4. Cell cycle-driven neuronal apoptosis specifically linked to amyloid peptide Abeta1-42 exposure is not exacerbated in a mouse model of presenilin-1 familial Alzheimer's disease.
    Malik B, Currais A, Soriano S.
    J Neurochem; 2008 Jul; 106(2):912-6. PubMed ID: 18466334
    [Abstract] [Full Text] [Related]

  • 5. Neurons overexpressing mutant presenilin-1 are more sensitive to apoptosis induced by endoplasmic reticulum-Golgi stress.
    Terro F, Czech C, Esclaire F, Elyaman W, Yardin C, Baclet MC, Touchet N, Tremp G, Pradier L, Hugon J.
    J Neurosci Res; 2002 Aug 15; 69(4):530-9. PubMed ID: 12210846
    [Abstract] [Full Text] [Related]

  • 6. Neuropathology of mice carrying mutant APP(swe) and/or PS1(M146L) transgenes: alterations in the p75(NTR) cholinergic basal forebrain septohippocampal pathway.
    Jaffar S, Counts SE, Ma SY, Dadko E, Gordon MN, Morgan D, Mufson EJ.
    Exp Neurol; 2001 Aug 15; 170(2):227-43. PubMed ID: 11476589
    [Abstract] [Full Text] [Related]

  • 7. Synaptic transmission and hippocampal long-term potentiation in transgenic mice expressing FAD-linked presenilin 1.
    Parent A, Linden DJ, Sisodia SS, Borchelt DR.
    Neurobiol Dis; 1999 Feb 15; 6(1):56-62. PubMed ID: 10078973
    [Abstract] [Full Text] [Related]

  • 8. The presenilin 1 C92S mutation increases abeta 42 production.
    Lewis PA, Perez-Tur J, Golde TE, Hardy J.
    Biochem Biophys Res Commun; 2000 Oct 14; 277(1):261-3. PubMed ID: 11027672
    [Abstract] [Full Text] [Related]

  • 9. Additive effects of PS1 and APP mutations on secretion of the 42-residue amyloid beta-protein.
    Citron M, Eckman CB, Diehl TS, Corcoran C, Ostaszewski BL, Xia W, Levesque G, St George Hyslop P, Younkin SG, Selkoe DJ.
    Neurobiol Dis; 1998 Aug 14; 5(2):107-16. PubMed ID: 9746908
    [Abstract] [Full Text] [Related]

  • 10. Abnormal intracellular trafficking of high affinity nerve growth factor receptor, Trk, in stable transfectants expressing presenilin 1 protein.
    Hamano T, Mutoh T, Tabira T, Araki W, Kuriyama M, Mihara T, Yano S, Yamamoto H.
    Brain Res Mol Brain Res; 2005 Jun 13; 137(1-2):70-6. PubMed ID: 15950763
    [Abstract] [Full Text] [Related]

  • 11. The presenilin 1 mutation (M146V) linked to familial Alzheimer's disease attenuates the neuronal differentiation of NTera 2 cells.
    Tokuhiro S, Tomita T, Iwata H, Kosaka T, Saido TC, Maruyama K, Iwatsubo T.
    Biochem Biophys Res Commun; 1998 Mar 27; 244(3):751-5. PubMed ID: 9535737
    [Abstract] [Full Text] [Related]

  • 12. Decreased Abeta secretion by cells expressing familial Alzheimer's disease-linked mutant presenilin 1.
    Shimojo M, Sahara N, Murayama M, Ichinose H, Takashima A.
    Neurosci Res; 2007 Mar 27; 57(3):446-53. PubMed ID: 17210196
    [Abstract] [Full Text] [Related]

  • 13. Functional phenotype in transgenic mice expressing mutant human presenilin-1.
    Barrow PA, Empson RM, Gladwell SJ, Anderson CM, Killick R, Yu X, Jefferys JG, Duff K.
    Neurobiol Dis; 2000 Apr 27; 7(2):119-26. PubMed ID: 10783295
    [Abstract] [Full Text] [Related]

  • 14. Presenilin-1 mutations downregulate the signalling pathway of the unfolded-protein response.
    Katayama T, Imaizumi K, Sato N, Miyoshi K, Kudo T, Hitomi J, Morihara T, Yoneda T, Gomi F, Mori Y, Nakano Y, Takeda J, Tsuda T, Itoyama Y, Murayama O, Takashima A, St George-Hyslop P, Takeda M, Tohyama M.
    Nat Cell Biol; 1999 Dec 27; 1(8):479-85. PubMed ID: 10587643
    [Abstract] [Full Text] [Related]

  • 15. Neural progenitor cells do not differentiate prematurely in presenilin-1 null mutant mice.
    Wen PH, De Gasperi R, Gama Sosa MA, Elder GA.
    Neurosci Lett; 2004 Nov 23; 371(2-3):249-54. PubMed ID: 15519767
    [Abstract] [Full Text] [Related]

  • 16. Presenilin 2 familial Alzheimer's disease mutations result in partial loss of function and dramatic changes in Abeta 42/40 ratios.
    Walker ES, Martinez M, Brunkan AL, Goate A.
    J Neurochem; 2005 Jan 23; 92(2):294-301. PubMed ID: 15663477
    [Abstract] [Full Text] [Related]

  • 17. Deficits in Enrichment-Dependent Neurogenesis and Enhanced Anxiety Behaviors Mediated by Expression of Alzheimer's Disease-Linked Ps1 Variants Are Rescued by Microglial Depletion.
    Ortega-Martinez S, Palla N, Zhang X, Lipman E, Sisodia SS.
    J Neurosci; 2019 Aug 21; 39(34):6766-6780. PubMed ID: 31217332
    [Abstract] [Full Text] [Related]

  • 18. Presenilin proteins undergo heterogeneous endoproteolysis between Thr291 and Ala299 and occur as stable N- and C-terminal fragments in normal and Alzheimer brain tissue.
    Podlisny MB, Citron M, Amarante P, Sherrington R, Xia W, Zhang J, Diehl T, Levesque G, Fraser P, Haass C, Koo EH, Seubert P, St George-Hyslop P, Teplow DB, Selkoe DJ.
    Neurobiol Dis; 1997 Aug 21; 3(4):325-37. PubMed ID: 9173929
    [Abstract] [Full Text] [Related]

  • 19. Alzheimer's disease-like alterations in peripheral cells from presenilin-1 transgenic mice.
    Eckert A, Schindowski K, Leutner S, Luckhaus C, Touchet N, Czech C, Müller WE.
    Neurobiol Dis; 2001 Apr 21; 8(2):331-42. PubMed ID: 11300728
    [Abstract] [Full Text] [Related]

  • 20. APP processing and amyloid deposition in mice haplo-insufficient for presenilin 1.
    Jankowsky JL, Slunt HH, Gonzales V, Jenkins NA, Copeland NG, Borchelt DR.
    Neurobiol Aging; 2004 Aug 21; 25(7):885-92. PubMed ID: 15212842
    [Abstract] [Full Text] [Related]

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