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294 related items for PubMed ID: 15252145

  • 1. Activation of protein kinase C betaII/epsilon-c-Jun NH2-terminal kinase pathway and inhibition of mitogen-activated protein/extracellular signal-regulated kinase 1/2 phosphorylation in antitumor invasive activity induced by the polymethoxy flavonoid, nobiletin.
    Miyata Y, Sato T, Yano M, Ito A.
    Mol Cancer Ther; 2004 Jul; 3(7):839-47. PubMed ID: 15252145
    [Abstract] [Full Text] [Related]

  • 2. Inhibition of activator protein-1 binding activity and phosphatidylinositol 3-kinase pathway by nobiletin, a polymethoxy flavonoid, results in augmentation of tissue inhibitor of metalloproteinases-1 production and suppression of production of matrix metalloproteinases-1 and -9 in human fibrosarcoma HT-1080 cells.
    Sato T, Koike L, Miyata Y, Hirata M, Mimaki Y, Sashida Y, Yano M, Ito A.
    Cancer Res; 2002 Feb 15; 62(4):1025-9. PubMed ID: 11861377
    [Abstract] [Full Text] [Related]

  • 3. Activated Ki-Ras suppresses 12-O-tetradecanoylphorbol-13-acetate-induced activation of the c-Jun NH2-terminal kinase pathway in human colon cancer cells.
    Okumura K, Shirasawa S, Nishioka M, Sasazuki T.
    Cancer Res; 1999 May 15; 59(10):2445-50. PubMed ID: 10344756
    [Abstract] [Full Text] [Related]

  • 4. c-Raf/MEK/ERK pathway controls protein kinase C-mediated p70S6K activation in adult cardiac muscle cells.
    Iijima Y, Laser M, Shiraishi H, Willey CD, Sundaravadivel B, Xu L, McDermott PJ, Kuppuswamy D.
    J Biol Chem; 2002 Jun 21; 277(25):23065-75. PubMed ID: 11940578
    [Abstract] [Full Text] [Related]

  • 5. FGF-2 and TPA induce matrix metalloproteinase-9 secretion in MCF-7 cells through PKC activation of the Ras/ERK pathway.
    Liu JF, Crépin M, Liu JM, Barritault D, Ledoux D.
    Biochem Biophys Res Commun; 2002 May 17; 293(4):1174-82. PubMed ID: 12054499
    [Abstract] [Full Text] [Related]

  • 6. Rapamycin and UCN-01 synergistically induce apoptosis in human leukemia cells through a process that is regulated by the Raf-1/MEK/ERK, Akt, and JNK signal transduction pathways.
    Hahn M, Li W, Yu C, Rahmani M, Dent P, Grant S.
    Mol Cancer Ther; 2005 Mar 17; 4(3):457-70. PubMed ID: 15767555
    [Abstract] [Full Text] [Related]

  • 7. Nobiletin induces inhibitions of Ras activity and mitogen-activated protein kinase kinase/extracellular signal-regulated kinase signaling to suppress cell proliferation in C6 rat glioma cells.
    Aoki K, Yokosuka A, Mimaki Y, Fukunaga K, Yamakuni T.
    Biol Pharm Bull; 2013 Mar 17; 36(4):540-7. PubMed ID: 23546290
    [Abstract] [Full Text] [Related]

  • 8. EGF-induced trophoblast secretion of MMP-9 and TIMP-1 involves activation of both PI3K and MAPK signalling pathways.
    Qiu Q, Yang M, Tsang BK, Gruslin A.
    Reproduction; 2004 Sep 17; 128(3):355-63. PubMed ID: 15333786
    [Abstract] [Full Text] [Related]

  • 9. Triptolide, a diterpenoid triepoxide, induces antitumor proliferation via activation of c-Jun NH2-terminal kinase 1 by decreasing phosphatidylinositol 3-kinase activity in human tumor cells.
    Miyata Y, Sato T, Ito A.
    Biochem Biophys Res Commun; 2005 Nov 04; 336(4):1081-6. PubMed ID: 16176806
    [Abstract] [Full Text] [Related]

  • 10. Andrographolide acts through inhibition of ERK1/2 and Akt phosphorylation to suppress chemotactic migration.
    Tsai HR, Yang LM, Tsai WJ, Chiou WF.
    Eur J Pharmacol; 2004 Sep 13; 498(1-3):45-52. PubMed ID: 15363974
    [Abstract] [Full Text] [Related]

  • 11. A citrus polymethoxyflavonoid, nobiletin, is a novel MEK inhibitor that exhibits antitumor metastasis in human fibrosarcoma HT-1080 cells.
    Miyata Y, Sato T, Imada K, Dobashi A, Yano M, Ito A.
    Biochem Biophys Res Commun; 2008 Feb 01; 366(1):168-73. PubMed ID: 18053806
    [Abstract] [Full Text] [Related]

  • 12. Suppression of phorbol-12-myristate-13-acetate-induced tumor cell invasion by bergamottin via the inhibition of protein kinase Cdelta/p38 mitogen-activated protein kinase and JNK/nuclear factor-kappaB-dependent matrix metalloproteinase-9 expression.
    Hwang YP, Yun HJ, Choi JH, Kang KW, Jeong HG.
    Mol Nutr Food Res; 2010 Jul 01; 54(7):977-90. PubMed ID: 19943262
    [Abstract] [Full Text] [Related]

  • 13. Activation of phosphatidylinositol 3-kinase and extracellular signal-regulated kinase is required for glial cell line-derived neurotrophic factor-induced migration and invasion of pancreatic carcinoma cells.
    Veit C, Genze F, Menke A, Hoeffert S, Gress TM, Gierschik P, Giehl K.
    Cancer Res; 2004 Aug 01; 64(15):5291-300. PubMed ID: 15289335
    [Abstract] [Full Text] [Related]

  • 14. Cross-talk between phosphatidylinositol 3-kinase/AKT and c-jun NH2-terminal kinase mediates survival of isolated human islets.
    Aikin R, Maysinger D, Rosenberg L.
    Endocrinology; 2004 Oct 01; 145(10):4522-31. PubMed ID: 15242986
    [Abstract] [Full Text] [Related]

  • 15. Fibronectin activates matrix metalloproteinase-9 secretion via the MEK1-MAPK and the PI3K-Akt pathways in ovarian cancer cells.
    Thant AA, Nawa A, Kikkawa F, Ichigotani Y, Zhang Y, Sein TT, Amin AR, Hamaguchi M.
    Clin Exp Metastasis; 2000 Oct 01; 18(5):423-8. PubMed ID: 11467775
    [Abstract] [Full Text] [Related]

  • 16. Transforming growth factor-beta1 induces tissue inhibitor of metalloproteinase-1 expression via activation of extracellular signal-regulated kinase and Sp1 in human fibrosarcoma cells.
    Kwak HJ, Park MJ, Cho H, Park CM, Moon SI, Lee HC, Park IC, Kim MS, Rhee CH, Hong SI.
    Mol Cancer Res; 2006 Mar 01; 4(3):209-20. PubMed ID: 16547158
    [Abstract] [Full Text] [Related]

  • 17. In vitro studies on nobiletin isolated from citrus plants and the bioactive metabolites, inhibitory action against gelatinase enzymatic activity and the molecular mechanisms in human retinal Müller cell line.
    Miyata Y, Nagase T, Katsura Y, Takahashi H, Natsugari H, Oshitari T, Kosano H.
    Biomed Pharmacother; 2017 Sep 01; 93():70-80. PubMed ID: 28623785
    [Abstract] [Full Text] [Related]

  • 18. Nobiletin, a citrus flavonoid, suppresses invasion and migration involving FAK/PI3K/Akt and small GTPase signals in human gastric adenocarcinoma AGS cells.
    Lee YC, Cheng TH, Lee JS, Chen JH, Liao YC, Fong Y, Wu CH, Shih YW.
    Mol Cell Biochem; 2011 Jan 01; 347(1-2):103-15. PubMed ID: 20963626
    [Abstract] [Full Text] [Related]

  • 19. Myricetin inhibits matrix metalloproteinase 2 protein expression and enzyme activity in colorectal carcinoma cells.
    Ko CH, Shen SC, Lee TJ, Chen YC.
    Mol Cancer Ther; 2005 Feb 01; 4(2):281-90. PubMed ID: 15713899
    [Abstract] [Full Text] [Related]

  • 20. Requirement for a hsp90 chaperone-dependent MEK1/2-ERK pathway for B cell antigen receptor-induced cyclin D2 expression in mature B lymphocytes.
    Piatelli MJ, Doughty C, Chiles TC.
    J Biol Chem; 2002 Apr 05; 277(14):12144-50. PubMed ID: 11823472
    [Abstract] [Full Text] [Related]

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