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124 related items for PubMed ID: 1525963

  • 1. Inhibitors of sterol synthesis. Chemical synthesis and spectral properties of (25R)-5 alpha-cholest-8(14)-ene-3 beta,15 beta,26-triol, a potential metabolite of 3 beta-hydroxy-5 alpha-cholest-8(14)-en-15-one and its effects on 3-hydroxy-3-methylglutaryl-coenzyme A reductase in CHO-K1 cells.
    Swaminathan S, Pinkerton FD, Wilson WK, Schroepfer GJ.
    Chem Phys Lipids; 1992 May; 61(3):235-42. PubMed ID: 1525963
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  • 2. Inhibitors of sterol synthesis. Chemical syntheses and spectral properties of 26-oxygenated derivatives of 3 beta-hydroxy-5 alpha-cholest-8(14)-en-15-one and their effects on 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in CHO-K1 cells.
    Siddiqui AU, Wilson WK, Ruecker KE, Pinkerton FD, Schroepfer GJ.
    Chem Phys Lipids; 1992 Nov; 63(1-2):77-90. PubMed ID: 1486662
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  • 3. Inhibitors of sterol synthesis. Chemical synthesis of 7 alpha-ethyl and 16 alpha-ethyl derivatives of delta 8(14)-15-oxygenated sterols and their effects on 3-hydroxy-3-methylglutaryl coenzyme A reductase in CHO-K1 cells.
    Kim HS, Wilson WK, Kirkpatrick ND, Pinkerton FD, Swaminathan S, Hylarides MD, Schroepfer GJ.
    Chem Phys Lipids; 1992 Jul; 62(1):55-67. PubMed ID: 1423803
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  • 6. Inhibitors of sterol synthesis. Chemical synthesis and spectral properties of 3 beta-hydroxy-5 alpha-cholesta-8(14),24-dien-15-one, 3 beta,25-dihydroxy-5 alpha-cholest-8(14)-en-15-one, and 3 beta,24-dihydroxy-5 alpha-cholest-8(14)-en-15-one and their effects on 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in CHO-K1 cells.
    Swaminathan S, Pinkerton FD, Numazawa S, Wilson WK, Schroepfer GJ.
    J Lipid Res; 1992 Oct; 33(10):1503-15. PubMed ID: 1431575
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  • 7. Inhibitors of sterol synthesis: effects of a 7 alpha-alkyl analog of 3 beta-hydroxy-5 alpha-cholest-8(14)-en-15-one on 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in cultured mammalian cells and on serum cholesterol levels and other parameters in rats.
    Siddiqui AU, Gerst N, Kim LJ, Pinkerton FD, Kisic A, Wilson WK, Schroepfer GJ.
    Chem Phys Lipids; 1994 Apr 19; 70(2):163-78. PubMed ID: 8033288
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  • 8. Inhibitors of sterol synthesis. Characterization of beta,gamma-unsaturated analogs of 3 beta-hydroxy-5 alpha-cholest-8(14)-en-15-one and their effects on 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in CHO-K1 cells.
    Wilson WK, Wheeler ME, Pinkerton FD, St Pyrek J, Schroepfer GJ.
    J Lipid Res; 1991 Jul 19; 32(7):1215-27. PubMed ID: 1940644
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  • 9. Inhibitors of sterol synthesis. Chemical synthesis, structure, and biological activities of (25R)-3 beta,26-dihydroxy-5 alpha-cholest-8(14)-en-15-one, a metabolite of 3 beta-hydroxy-5 alpha-cholest-8(14)-en-15-one.
    Kim HS, Wilson WK, Needleman DH, Pinkerton FD, Wilson DK, Quiocho FA, Schroepfer GJ.
    J Lipid Res; 1989 Feb 19; 30(2):247-61. PubMed ID: 2715729
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  • 10. Inhibitors of sterol synthesis. Synthesis and spectral properties of 3 beta-hydroxy-5 alpha-cholestan-15-one and its 17 beta-epimer and their effects on 3-hydroxy-3-methylglutaryl coenzyme A reductase activity.
    Siddiqui AU, Wilson WK, Parish EJ, Gerst N, Pinkerton FD, Schroepfer GJ.
    Chem Phys Lipids; 1994 Oct 20; 74(1):1-15. PubMed ID: 7820900
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  • 11. Inhibitors of sterol synthesis. A highly efficient and specific side-chain oxidation of 3 beta-acetoxy-5 alpha-cholest-8(14)-en-15-one for construction of metabolites and analogs of the 15-ketosterol.
    Herz JE, Swaminathan S, Pinkerton FD, Wilson WK, Schroepfer GJ.
    J Lipid Res; 1992 Apr 20; 33(4):579-98. PubMed ID: 1527481
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  • 12. Inhibitors of sterol synthesis. Differential effects of 14 alpha-hydroxymethyl-5 alpha-cholest-7-ene-3 beta, 15 alpha-diol and 14 alpha-hydroxymethyl-5 alpha-cholest-6-ene-3 beta, 15 alpha-diol on sterol synthesis in cell-free homogenates of rat liver.
    Miller LR, Pascal RA, Schroepfer GJ.
    J Biol Chem; 1981 Aug 10; 256(15):8085-91. PubMed ID: 7263642
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  • 13. Inhibitors of sterol synthesis: synthesis and spectral properties of derivatives of 3 beta-hydroxy-25,26,26,26,27,27,27-heptafluoro-5 alpha-cholest-8(14)-en-15-one fluorinated at carbon 7 or carbon 9 and their effects on 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in cultured mammalian cells.
    Siddiqui AU, Swaminathan S, Pinkerton FD, Gerst N, Wilson WK, Choi H, Schroephfer GJ.
    Chem Phys Lipids; 1994 Jun 24; 72(1):59-75. PubMed ID: 7923480
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  • 14. Enzymatic formation and chemical synthesis of an active metabolite of 3 beta-hydroxy-5 alpha-cholest-8(14)-en-15-one, a potent regulator of cholesterol metabolism.
    Schroepfer GJ, Kim HS, Vermilion JL, Stephens TW, Pinkerton FD, Needleman DH, Wilson WK, St Pyrek J.
    Biochem Biophys Res Commun; 1988 Feb 29; 151(1):130-6. PubMed ID: 3348769
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  • 15. Inhibitors of sterol synthesis. Chemical synthesis of 5 beta-cholest-8-ene-3 beta,15 alpha-diol and its effects on 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in CHO-K1 cells.
    Wilson WK, Pinkerton FD, Kirkpatrick ND, Schroepfer GJ.
    J Lipid Res; 1989 Jun 29; 30(6):919-28. PubMed ID: 2794782
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  • 17. Synergistic action of two oxysterols in the lowering of HMG-CoA reductase activity in CHO-K1 cells.
    Pinkerton FD, Pelley RP, Schroepfer GJ.
    Biochem Biophys Res Commun; 1992 Jul 15; 186(1):569-73. PubMed ID: 1632792
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  • 18. Inhibitors of sterol synthesis. Synthesis and spectral properties of 3 beta-hydroxy-24-dimethylamino-5 alpha-chol-8(14)-en-15-one and its effects on HMG-CoA reductase activity in CHO-K1 cells.
    Herz JE, Wilson WK, Pinkerton FD, Schroepfer GJ.
    Chem Phys Lipids; 1991 Nov 15; 60(1):61-9. PubMed ID: 1813179
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  • 19. Inhibitors of sterol synthesis. Effects of fluorine substitution at carbon atom 25 of cholesterol on its spectral and chromatographic properties and on 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in CHO-K1 cells.
    Wilson WK, Swaminathan S, Pinkerton FD, Gerst N, Schroepfer GJ.
    Steroids; 1994 May 15; 59(5):310-7. PubMed ID: 8073444
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  • 20. Inhibitors of sterol synthesis. Characterization of side chain oxygenated derivatives formed upon incubation of 3 beta-hydroxy-5 alpha-cholest-8(14)-en-15-one with rat liver mitochondria.
    Pyrek JS, Vermilion JL, Stephens TW, Wilson WK, Schroepfer GJ.
    J Biol Chem; 1989 Mar 15; 264(8):4536-43. PubMed ID: 2925655
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