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270 related items for PubMed ID: 15274641

  • 1. A disubstituted succinamide is a potent sodium channel blocker with efficacy in a rat pain model.
    Priest BT, Garcia ML, Middleton RE, Brochu RM, Clark S, Dai G, Dick IE, Felix JP, Liu CJ, Reiseter BS, Schmalhofer WA, Shao PP, Tang YS, Chou MZ, Kohler MG, Smith MM, Warren VA, Williams BS, Cohen CJ, Martin WJ, Meinke PT, Parsons WH, Wafford KA, Kaczorowski GJ.
    Biochemistry; 2004 Aug 03; 43(30):9866-76. PubMed ID: 15274641
    [Abstract] [Full Text] [Related]

  • 2. A-887826 is a structurally novel, potent and voltage-dependent Na(v)1.8 sodium channel blocker that attenuates neuropathic tactile allodynia in rats.
    Zhang XF, Shieh CC, Chapman ML, Matulenko MA, Hakeem AH, Atkinson RN, Kort ME, Marron BE, Joshi S, Honore P, Faltynek CR, Krafte DS, Jarvis MF.
    Neuropharmacology; 2010 Sep 03; 59(3):201-7. PubMed ID: 20566409
    [Abstract] [Full Text] [Related]

  • 3. Discovery and biological evaluation of 5-aryl-2-furfuramides, potent and selective blockers of the Nav1.8 sodium channel with efficacy in models of neuropathic and inflammatory pain.
    Kort ME, Drizin I, Gregg RJ, Scanio MJ, Shi L, Gross MF, Atkinson RN, Johnson MS, Pacofsky GJ, Thomas JB, Carroll WA, Krambis MJ, Liu D, Shieh CC, Zhang X, Hernandez G, Mikusa JP, Zhong C, Joshi S, Honore P, Roeloffs R, Marsh KC, Murray BP, Liu J, Werness S, Faltynek CR, Krafte DS, Jarvis MF, Chapman ML, Marron BE.
    J Med Chem; 2008 Feb 14; 51(3):407-16. PubMed ID: 18176998
    [Abstract] [Full Text] [Related]

  • 4. A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat.
    Jarvis MF, Honore P, Shieh CC, Chapman M, Joshi S, Zhang XF, Kort M, Carroll W, Marron B, Atkinson R, Thomas J, Liu D, Krambis M, Liu Y, McGaraughty S, Chu K, Roeloffs R, Zhong C, Mikusa JP, Hernandez G, Gauvin D, Wade C, Zhu C, Pai M, Scanio M, Shi L, Drizin I, Gregg R, Matulenko M, Hakeem A, Gross M, Johnson M, Marsh K, Wagoner PK, Sullivan JP, Faltynek CR, Krafte DS.
    Proc Natl Acad Sci U S A; 2007 May 15; 104(20):8520-5. PubMed ID: 17483457
    [Abstract] [Full Text] [Related]

  • 5. The neuroleptic drug, fluphenazine, blocks neuronal voltage-gated sodium channels.
    Zhou X, Dong XW, Priestley T.
    Brain Res; 2006 Aug 23; 1106(1):72-81. PubMed ID: 16839522
    [Abstract] [Full Text] [Related]

  • 6. Heterologous expression and functional analysis of rat Nav1.8 (SNS) voltage-gated sodium channels in the dorsal root ganglion neuroblastoma cell line ND7-23.
    John VH, Main MJ, Powell AJ, Gladwell ZM, Hick C, Sidhu HS, Clare JJ, Tate S, Trezise DJ.
    Neuropharmacology; 2004 Mar 23; 46(3):425-38. PubMed ID: 14975698
    [Abstract] [Full Text] [Related]

  • 7. The TTX metabolite 4,9-anhydro-TTX is a highly specific blocker of the Na(v1.6) voltage-dependent sodium channel.
    Rosker C, Lohberger B, Hofer D, Steinecker B, Quasthoff S, Schreibmayer W.
    Am J Physiol Cell Physiol; 2007 Aug 23; 293(2):C783-9. PubMed ID: 17522141
    [Abstract] [Full Text] [Related]

  • 8. Comparison of the effects of four Na+ channel analgesics on TTX-resistant Na+ currents in rat sensory neurons and recombinant Nav1.2 channels.
    Weiser T.
    Neurosci Lett; 2006 Mar 13; 395(3):179-84. PubMed ID: 16293367
    [Abstract] [Full Text] [Related]

  • 9. Inhibition of voltage-gated Na(+) currents in sensory neurones by the sea anemone toxin APETx2.
    Blanchard MG, Rash LD, Kellenberger S.
    Br J Pharmacol; 2012 Apr 13; 165(7):2167-77. PubMed ID: 21943094
    [Abstract] [Full Text] [Related]

  • 10. State- and use-dependent block of muscle Nav1.4 and neuronal Nav1.7 voltage-gated Na+ channel isoforms by ranolazine.
    Wang GK, Calderon J, Wang SY.
    Mol Pharmacol; 2008 Mar 13; 73(3):940-8. PubMed ID: 18079277
    [Abstract] [Full Text] [Related]

  • 11. Novel cyclopentane dicarboxamide sodium channel blockers as a potential treatment for chronic pain.
    Shao PP, Ok D, Fisher MH, Garcia ML, Kaczorowski GJ, Li C, Lyons KA, Martin WJ, Meinke PT, Priest BT, Smith MM, Wyvratt MJ, Ye F, Parsons WH.
    Bioorg Med Chem Lett; 2005 Apr 01; 15(7):1901-7. PubMed ID: 15780630
    [Abstract] [Full Text] [Related]

  • 12. Identification of a potent, state-dependent inhibitor of Nav1.7 with oral efficacy in the formalin model of persistent pain.
    Bregman H, Berry L, Buchanan JL, Chen A, Du B, Feric E, Hierl M, Huang L, Immke D, Janosky B, Johnson D, Li X, Ligutti J, Liu D, Malmberg A, Matson D, McDermott J, Miu P, Nguyen HN, Patel VF, Waldon D, Wilenkin B, Zheng XM, Zou A, McDonough SI, DiMauro EF.
    J Med Chem; 2011 Jul 14; 54(13):4427-45. PubMed ID: 21634377
    [Abstract] [Full Text] [Related]

  • 13. muO-conotoxin MrVIB selectively blocks Nav1.8 sensory neuron specific sodium channels and chronic pain behavior without motor deficits.
    Ekberg J, Jayamanne A, Vaughan CW, Aslan S, Thomas L, Mould J, Drinkwater R, Baker MD, Abrahamsen B, Wood JN, Adams DJ, Christie MJ, Lewis RJ.
    Proc Natl Acad Sci U S A; 2006 Nov 07; 103(45):17030-5. PubMed ID: 17077153
    [Abstract] [Full Text] [Related]

  • 14. V102862 (Co 102862): a potent, broad-spectrum state-dependent blocker of mammalian voltage-gated sodium channels.
    Ilyin VI, Hodges DD, Whittemore ER, Carter RB, Cai SX, Woodward RM.
    Br J Pharmacol; 2005 Mar 07; 144(6):801-12. PubMed ID: 15778702
    [Abstract] [Full Text] [Related]

  • 15. Modulation of peripheral Na(+) channels and neuronal firing by n-butyl-p-aminobenzoate.
    Thériault O, Poulin H, Sculptoreanu A, de Groat WC, O'Leary ME, Chahine M.
    Eur J Pharmacol; 2014 Mar 15; 727():158-66. PubMed ID: 24486399
    [Abstract] [Full Text] [Related]

  • 16. The muO-conotoxin MrVIA inhibits voltage-gated sodium channels by associating with domain-3.
    Zorn S, Leipold E, Hansel A, Bulaj G, Olivera BM, Terlau H, Heinemann SH.
    FEBS Lett; 2006 Feb 20; 580(5):1360-4. PubMed ID: 16458302
    [Abstract] [Full Text] [Related]

  • 17. Recombinant PaurTx-3, a spider toxin, inhibits sodium channels and decreases membrane excitability in DRG neurons.
    Chen M, Peng S, Wang L, Yang L, Si Y, Zhou X, Zhang Y, Liu Z.
    Biochem Biophys Res Commun; 2020 Dec 17; 533(4):958-964. PubMed ID: 33004176
    [Abstract] [Full Text] [Related]

  • 18. Use-dependent block by lidocaine but not amitriptyline is more pronounced in tetrodotoxin (TTX)-Resistant Nav1.8 than in TTX-sensitive Na+ channels.
    Leffler A, Reiprich A, Mohapatra DP, Nau C.
    J Pharmacol Exp Ther; 2007 Jan 17; 320(1):354-64. PubMed ID: 17005919
    [Abstract] [Full Text] [Related]

  • 19. A novel slow-inactivation-specific ion channel modulator attenuates neuropathic pain.
    Hildebrand ME, Smith PL, Bladen C, Eduljee C, Xie JY, Chen L, Fee-Maki M, Doering CJ, Mezeyova J, Zhu Y, Belardetti F, Pajouhesh H, Parker D, Arneric SP, Parmar M, Porreca F, Tringham E, Zamponi GW, Snutch TP.
    Pain; 2011 Apr 17; 152(4):833-843. PubMed ID: 21349638
    [Abstract] [Full Text] [Related]

  • 20. 3-Oxoisoindoline-1-carboxamides: potent, state-dependent blockers of voltage-gated sodium channel Na(V)1.7 with efficacy in rat pain models.
    Macsari I, Besidski Y, Csjernyik G, Nilsson LI, Sandberg L, Yngve U, Ahlin K, Bueters T, Eriksson AB, Lund PE, Venyike E, Oerther S, Hygge Blakeman K, Luo L, Arvidsson PI.
    J Med Chem; 2012 Aug 09; 55(15):6866-80. PubMed ID: 22770500
    [Abstract] [Full Text] [Related]

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