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1718 related items for PubMed ID: 15282312

  • 1. Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2.
    Kobayashi A, Kang MI, Okawa H, Ohtsuji M, Zenke Y, Chiba T, Igarashi K, Yamamoto M.
    Mol Cell Biol; 2004 Aug; 24(16):7130-9. PubMed ID: 15282312
    [Abstract] [Full Text] [Related]

  • 2. BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase.
    Furukawa M, Xiong Y.
    Mol Cell Biol; 2005 Jan; 25(1):162-71. PubMed ID: 15601839
    [Abstract] [Full Text] [Related]

  • 3. Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex.
    Zhang DD, Lo SC, Cross JV, Templeton DJ, Hannink M.
    Mol Cell Biol; 2004 Dec; 24(24):10941-53. PubMed ID: 15572695
    [Abstract] [Full Text] [Related]

  • 4. Ubiquitination of Keap1, a BTB-Kelch substrate adaptor protein for Cul3, targets Keap1 for degradation by a proteasome-independent pathway.
    Zhang DD, Lo SC, Sun Z, Habib GM, Lieberman MW, Hannink M.
    J Biol Chem; 2005 Aug 26; 280(34):30091-9. PubMed ID: 15983046
    [Abstract] [Full Text] [Related]

  • 5. Regulation of the Nrf2-Keap1 antioxidant response by the ubiquitin proteasome system: an insight into cullin-ring ubiquitin ligases.
    Villeneuve NF, Lau A, Zhang DD.
    Antioxid Redox Signal; 2010 Dec 01; 13(11):1699-712. PubMed ID: 20486766
    [Abstract] [Full Text] [Related]

  • 6. CAND1-mediated substrate adaptor recycling is required for efficient repression of Nrf2 by Keap1.
    Lo SC, Hannink M.
    Mol Cell Biol; 2006 Feb 01; 26(4):1235-44. PubMed ID: 16449638
    [Abstract] [Full Text] [Related]

  • 7. The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: oxidative stress sensing by a Cul3-Keap1 ligase.
    Cullinan SB, Gordan JD, Jin J, Harper JW, Diehl JA.
    Mol Cell Biol; 2004 Oct 01; 24(19):8477-86. PubMed ID: 15367669
    [Abstract] [Full Text] [Related]

  • 8. Structural and biochemical characterization establishes a detailed understanding of KEAP1-CUL3 complex assembly.
    Adamson RJ, Payne NC, Bartual SG, Mazitschek R, Bullock AN.
    Free Radic Biol Med; 2023 Aug 01; 204():215-225. PubMed ID: 37156295
    [Abstract] [Full Text] [Related]

  • 9. Absolute Amounts and Status of the Nrf2-Keap1-Cul3 Complex within Cells.
    Iso T, Suzuki T, Baird L, Yamamoto M.
    Mol Cell Biol; 2016 Dec 15; 36(24):3100-3112. PubMed ID: 27697860
    [Abstract] [Full Text] [Related]

  • 10. Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression.
    McMahon M, Itoh K, Yamamoto M, Hayes JD.
    J Biol Chem; 2003 Jun 13; 278(24):21592-600. PubMed ID: 12682069
    [Abstract] [Full Text] [Related]

  • 11. A noncanonical mechanism of Nrf2 activation by autophagy deficiency: direct interaction between Keap1 and p62.
    Lau A, Wang XJ, Zhao F, Villeneuve NF, Wu T, Jiang T, Sun Z, White E, Zhang DD.
    Mol Cell Biol; 2010 Jul 13; 30(13):3275-85. PubMed ID: 20421418
    [Abstract] [Full Text] [Related]

  • 12. Specific patterns of electrophile adduction trigger Keap1 ubiquitination and Nrf2 activation.
    Hong F, Sekhar KR, Freeman ML, Liebler DC.
    J Biol Chem; 2005 Sep 09; 280(36):31768-75. PubMed ID: 15985429
    [Abstract] [Full Text] [Related]

  • 13. Diffusion dynamics of the Keap1-Cullin3 interaction in single live cells.
    Baird L, Dinkova-Kostova AT.
    Biochem Biophys Res Commun; 2013 Mar 29; 433(1):58-65. PubMed ID: 23454126
    [Abstract] [Full Text] [Related]

  • 14. Zinc-binding triggers a conformational-switch in the cullin-3 substrate adaptor protein KEAP1 that controls transcription factor NRF2.
    McMahon M, Swift SR, Hayes JD.
    Toxicol Appl Pharmacol; 2018 Dec 01; 360():45-57. PubMed ID: 30261176
    [Abstract] [Full Text] [Related]

  • 15. p97 Negatively Regulates NRF2 by Extracting Ubiquitylated NRF2 from the KEAP1-CUL3 E3 Complex.
    Tao S, Liu P, Luo G, Rojo de la Vega M, Chen H, Wu T, Tillotson J, Chapman E, Zhang DD.
    Mol Cell Biol; 2017 Apr 15; 37(8):. PubMed ID: 28115426
    [Abstract] [Full Text] [Related]

  • 16. The Keap1-Nrf2 system as an in vivo sensor for electrophiles.
    Uruno A, Motohashi H.
    Nitric Oxide; 2011 Aug 01; 25(2):153-60. PubMed ID: 21385624
    [Abstract] [Full Text] [Related]

  • 17. Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy.
    Shibata T, Ohta T, Tong KI, Kokubu A, Odogawa R, Tsuta K, Asamura H, Yamamoto M, Hirohashi S.
    Proc Natl Acad Sci U S A; 2008 Sep 09; 105(36):13568-73. PubMed ID: 18757741
    [Abstract] [Full Text] [Related]

  • 18. Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress.
    Zhang DD, Hannink M.
    Mol Cell Biol; 2003 Nov 09; 23(22):8137-51. PubMed ID: 14585973
    [Abstract] [Full Text] [Related]

  • 19. Molecular mechanisms of the Keap1–Nrf2 pathway in stress response and cancer evolution.
    Taguchi K, Motohashi H, Yamamoto M.
    Genes Cells; 2011 Feb 09; 16(2):123-40. PubMed ID: 21251164
    [Abstract] [Full Text] [Related]

  • 20. Unique pattern of component gene disruption in the NRF2 inhibitor KEAP1/CUL3/RBX1 E3-ubiquitin ligase complex in serous ovarian cancer.
    Martinez VD, Vucic EA, Thu KL, Pikor LA, Hubaux R, Lam WL.
    Biomed Res Int; 2014 Feb 09; 2014():159459. PubMed ID: 25114896
    [Abstract] [Full Text] [Related]

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