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Journal Abstract Search

609 related items for PubMed ID: 15294456

  • 1. Pharmacological and behavioral properties of A-349821, a selective and potent human histamine H3 receptor antagonist.
    Esbenshade TA, Fox GB, Krueger KM, Baranowski JL, Miller TR, Kang CH, Denny LI, Witte DG, Yao BB, Pan JB, Faghih R, Bennani YL, Williams M, Hancock AA.
    Biochem Pharmacol; 2004 Sep 01; 68(5):933-45. PubMed ID: 15294456
    [Abstract] [Full Text] [Related]

  • 2. Two novel and selective nonimidazole histamine H3 receptor antagonists A-304121 and A-317920: I. In vitro pharmacological effects.
    Esbenshade TA, Krueger KM, Miller TR, Kang CH, Denny LI, Witte DG, Yao BB, Fox GB, Faghih R, Bennani YL, Williams M, Hancock AA.
    J Pharmacol Exp Ther; 2003 Jun 01; 305(3):887-96. PubMed ID: 12606603
    [Abstract] [Full Text] [Related]

  • 3. Pharmacological properties of ABT-239 [4-(2-{2-[(2R)-2-Methylpyrrolidinyl]ethyl}-benzofuran-5-yl)benzonitrile]: I. Potent and selective histamine H3 receptor antagonist with drug-like properties.
    Esbenshade TA, Fox GB, Krueger KM, Miller TR, Kang CH, Denny LI, Witte DG, Yao BB, Pan L, Wetter J, Marsh K, Bennani YL, Cowart MD, Sullivan JP, Hancock AA.
    J Pharmacol Exp Ther; 2005 Apr 01; 313(1):165-75. PubMed ID: 15608078
    [Abstract] [Full Text] [Related]

  • 4. Structurally novel histamine H3 receptor antagonists GSK207040 and GSK334429 improve scopolamine-induced memory impairment and capsaicin-induced secondary allodynia in rats.
    Medhurst AD, Briggs MA, Bruton G, Calver AR, Chessell I, Crook B, Davis JB, Davis RP, Foley AG, Heslop T, Hirst WD, Medhurst SJ, Ociepka S, Ray A, Regan CM, Sargent B, Schogger J, Stean TO, Trail BK, Upton N, White T, Orlek B, Wilson DM.
    Biochem Pharmacol; 2007 Apr 15; 73(8):1182-94. PubMed ID: 17276409
    [Abstract] [Full Text] [Related]

  • 5. G protein-dependent pharmacology of histamine H3 receptor ligands: evidence for heterogeneous active state receptor conformations.
    Krueger KM, Witte DG, Ireland-Denny L, Miller TR, Baranowski JL, Buckner S, Milicic I, Esbenshade TA, Hancock AA.
    J Pharmacol Exp Ther; 2005 Jul 15; 314(1):271-81. PubMed ID: 15821027
    [Abstract] [Full Text] [Related]

  • 6. Pharmacological properties of ABT-239 [4-(2-{2-[(2R)-2-Methylpyrrolidinyl]ethyl}-benzofuran-5-yl)benzonitrile]: II. Neurophysiological characterization and broad preclinical efficacy in cognition and schizophrenia of a potent and selective histamine H3 receptor antagonist.
    Fox GB, Esbenshade TA, Pan JB, Radek RJ, Krueger KM, Yao BB, Browman KE, Buckley MJ, Ballard ME, Komater VA, Miner H, Zhang M, Faghih R, Rueter LE, Bitner RS, Drescher KU, Wetter J, Marsh K, Lemaire M, Porsolt RD, Bennani YL, Sullivan JP, Cowart MD, Decker MW, Hancock AA.
    J Pharmacol Exp Ther; 2005 Apr 15; 313(1):176-90. PubMed ID: 15608077
    [Abstract] [Full Text] [Related]

  • 7. Pharmacological characterization of the novel histamine H3-receptor antagonist N-(3,5-dichlorophenyl)-N'-[[4-(1H-imidazol-4-ylmethyl)phenyl]-methyl]-urea (SCH 79687).
    McLeod RL, Rizzo CA, West RE, Aslanian R, McCormick K, Bryant M, Hsieh Y, Korfmacher W, Mingo GG, Varty L, Williams SM, Shih NY, Egan RW, Hey JA.
    J Pharmacol Exp Ther; 2003 Jun 15; 305(3):1037-44. PubMed ID: 12649305
    [Abstract] [Full Text] [Related]

  • 8. Studies on the pharmacology of the novel histamine H3 receptor agonist Sch 50971.
    Hey JA, Aslanian R, Bolser DC, Chapman RW, Egan RW, Rizzo CA, Shih NY, Fernandez X, McLeod RL, West R, Kreutner W.
    Arzneimittelforschung; 1998 Sep 15; 48(9):881-8. PubMed ID: 9793613
    [Abstract] [Full Text] [Related]

  • 9. Two novel and selective nonimidazole H3 receptor antagonists A-304121 and A-317920: II. In vivo behavioral and neurophysiological characterization.
    Fox GB, Pan JB, Radek RJ, Lewis AM, Bitner RS, Esbenshade TA, Faghih R, Bennani YL, Williams M, Yao BB, Decker MW, Hancock AA.
    J Pharmacol Exp Ther; 2003 Jun 15; 305(3):897-908. PubMed ID: 12606600
    [Abstract] [Full Text] [Related]

  • 10. Neurochemical and behavioral effects of ciproxifan, a potent histamine H3-receptor antagonist.
    Ligneau X, Lin J, Vanni-Mercier G, Jouvet M, Muir JL, Ganellin CR, Stark H, Elz S, Schunack W, Schwartz J.
    J Pharmacol Exp Ther; 1998 Nov 15; 287(2):658-66. PubMed ID: 9808693
    [Abstract] [Full Text] [Related]

  • 11. Histamine H3-receptor-mediated [35S]GTP gamma[S] binding: evidence for constitutive activity of the recombinant and native rat and human H3 receptors.
    Rouleau A, Ligneau X, Tardivel-Lacombe J, Morisset S, Gbahou F, Schwartz JC, Arrang JM.
    Br J Pharmacol; 2002 Jan 15; 135(2):383-92. PubMed ID: 11815373
    [Abstract] [Full Text] [Related]

  • 12. Identification and pharmacological characterization of a series of new 1H-4-substituted-imidazoyl histamine H3 receptor ligands.
    Yates SL, Phillips JG, Gregory R, Pawlowski GP, Fadnis L, Khan MA, Ali SM, Tedford CE.
    J Pharmacol Exp Ther; 1999 May 15; 289(2):1151-9. PubMed ID: 10215699
    [Abstract] [Full Text] [Related]

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  • 14. Detection of multiple H3 receptor affinity states utilizing [3H]A-349821, a novel, selective, non-imidazole histamine H3 receptor inverse agonist radioligand.
    Witte DG, Yao BB, Miller TR, Carr TL, Cassar S, Sharma R, Faghih R, Surber BW, Esbenshade TA, Hancock AA, Krueger KM.
    Br J Pharmacol; 2006 Jul 15; 148(5):657-70. PubMed ID: 16715122
    [Abstract] [Full Text] [Related]

  • 15. High constitutive activity of native H3 receptors regulates histamine neurons in brain.
    Morisset S, Rouleau A, Ligneau X, Gbahou F, Tardivel-Lacombe J, Stark H, Schunack W, Ganellin CR, Schwartz JC, Arrang JM.
    Nature; 2000 Dec 14; 408(6814):860-4. PubMed ID: 11130725
    [Abstract] [Full Text] [Related]

  • 16. Development of chiral N-alkylcarbamates as new leads for potent and selective H3-receptor antagonists: synthesis, capillary electrophoresis, and in vitro and oral in vivo activity.
    Sasse A, Kiec-Kononowicz K, Stark H, Motyl M, Reidemeister S, Ganellin CR, Ligneau X, Schwartz JC, Schunack W.
    J Med Chem; 1999 Feb 25; 42(4):593-600. PubMed ID: 10052966
    [Abstract] [Full Text] [Related]

  • 17. SB-616234-A (1-[6-(cis-3,5-dimethylpiperazin-1-yl)-2,3-dihydro-5-methoxyindol-1-yl]-1-[2'methyl-4'-(5-methyl-1,2,3-oxadiazol-3-yl)biphenyl-4-yl]methanone hydrochloride): a novel, potent and selective 5-HT1B receptor antagonist.
    Scott C, Langmead CJ, Clarke KL, Wyman P, Smith PW, Starr KR, Dawson LA, Price GW, Hagan JJ, Watson J.
    Neuropharmacology; 2006 Jun 25; 50(8):984-90. PubMed ID: 16546225
    [Abstract] [Full Text] [Related]

  • 18. Detailed pharmacological characterization of GT-2331 for the rat histamine H3 receptor.
    Ito S, Yoshimoto R, Miyamoto Y, Mitobe Y, Nakamura T, Ishihara A, MacNeil DJ, Kanatani A, Tokita S.
    Eur J Pharmacol; 2006 Jan 04; 529(1-3):40-6. PubMed ID: 16316645
    [Abstract] [Full Text] [Related]

  • 19. In vitro optimization of structure activity relationships of analogues of A-331440 combining radioligand receptor binding assays and micronucleus assays of potential antiobesity histamine H3 receptor antagonists.
    Hancock AA, Diehl MS, Faghih R, Bush EN, Krueger KM, Krishna G, Miller TR, Wilcox DM, Nguyen P, Pratt JK, Cowart MD, Esbenshade TA, Jacobson PB.
    Basic Clin Pharmacol Toxicol; 2004 Sep 04; 95(3):144-52. PubMed ID: 15447739
    [Abstract] [Full Text] [Related]

  • 20. Pharmacological properties and procognitive effects of ABT-288, a potent and selective histamine H3 receptor antagonist.
    Esbenshade TA, Browman KE, Miller TR, Krueger KM, Komater-Roderwald V, Zhang M, Fox GB, Rueter L, Robb HM, Radek RJ, Drescher KU, Fey TA, Bitner RS, Marsh K, Polakowski JS, Zhao C, Cowart MD, Hancock AA, Sullivan JP, Brioni JD.
    J Pharmacol Exp Ther; 2012 Oct 04; 343(1):233-45. PubMed ID: 22815533
    [Abstract] [Full Text] [Related]

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