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1211 related items for PubMed ID: 15298346

  • 1. Pancreatic islets from cyclin-dependent kinase 4/R24C (Cdk4) knockin mice have significantly increased beta cell mass and are physiologically functional, indicating that Cdk4 is a potential target for pancreatic beta cell mass regeneration in Type 1 diabetes.
    Marzo N, Mora C, Fabregat ME, Martín J, Usac EF, Franco C, Barbacid M, Gomis R.
    Diabetologia; 2004 Apr; 47(4):686-94. PubMed ID: 15298346
    [Abstract] [Full Text] [Related]

  • 2. In vivo proliferation of differentiated pancreatic islet beta cells in transgenic mice expressing mutated cyclin-dependent kinase 4.
    Hino S, Yamaoka T, Yamashita Y, Yamada T, Hata J, Itakura M.
    Diabetologia; 2004 Oct; 47(10):1819-30. PubMed ID: 15480536
    [Abstract] [Full Text] [Related]

  • 3. Cyclin-dependent kinase 4 hyperactivity promotes autoreactivity in the immune system but protects pancreatic cell mass from autoimmune destruction in the nonobese diabetic mouse model.
    Marzo N, Ortega S, Stratmann T, García A, Ríos M, Giménez A, Gomis R, Mora C.
    J Immunol; 2008 Jan 15; 180(2):1189-98. PubMed ID: 18178859
    [Abstract] [Full Text] [Related]

  • 4. Overexpression of pre-pro-cholecystokinin stimulates beta-cell proliferation in mouse and human islets with retention of islet function.
    Lavine JA, Raess PW, Davis DB, Rabaglia ME, Presley BK, Keller MP, Beinfeld MC, Kopin AS, Newgard CB, Attie AD.
    Mol Endocrinol; 2008 Dec 15; 22(12):2716-28. PubMed ID: 18845673
    [Abstract] [Full Text] [Related]

  • 5. Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in beta-islet cell hyperplasia.
    Rane SG, Dubus P, Mettus RV, Galbreath EJ, Boden G, Reddy EP, Barbacid M.
    Nat Genet; 1999 May 15; 22(1):44-52. PubMed ID: 10319860
    [Abstract] [Full Text] [Related]

  • 6. Transgenic mice expressing Shb adaptor protein under the control of rat insulin promoter exhibit altered viability of pancreatic islet cells.
    Welsh M, Christmansson L, Karlsson T, Sandler S, Welsh N.
    Mol Med; 1999 Mar 15; 5(3):169-80. PubMed ID: 10404514
    [Abstract] [Full Text] [Related]

  • 7. Increased cytokine-induced cytotoxicity of pancreatic islet cells from transgenic mice expressing the Src-like tyrosine kinase GTK.
    Annerén C, Welsh M.
    Mol Med; 2001 May 15; 7(5):301-10. PubMed ID: 11474576
    [Abstract] [Full Text] [Related]

  • 8. Cdk4 regulates recruitment of quiescent beta-cells and ductal epithelial progenitors to reconstitute beta-cell mass.
    Lee JH, Jo J, Hardikar AA, Periwal V, Rane SG.
    PLoS One; 2010 Jan 13; 5(1):e8653. PubMed ID: 20084282
    [Abstract] [Full Text] [Related]

  • 9. Evidence for a local angiotensin-generating system and dose-dependent inhibition of glucose-stimulated insulin release by angiotensin II in isolated pancreatic islets.
    Lau T, Carlsson PO, Leung PS.
    Diabetologia; 2004 Feb 13; 47(2):240-8. PubMed ID: 14722647
    [Abstract] [Full Text] [Related]

  • 10. Functional and immunohistochemical evaluation of porcine neonatal islet-like cell clusters.
    Nielsen TB, Yderstraede KB, Schrøder HD, Holst JJ, Brusgaard K, Beck-Nielsen H.
    Cell Transplant; 2003 Feb 13; 12(1):13-25. PubMed ID: 12693660
    [Abstract] [Full Text] [Related]

  • 11. Adeno-associated virus vector mediated gene transfer to pancreatic beta cells.
    Prasad KM, Yang Z, Bleich D, Nadler JL.
    Gene Ther; 2000 Sep 13; 7(18):1553-61. PubMed ID: 11021593
    [Abstract] [Full Text] [Related]

  • 12. Targeted deletion of the PRL receptor: effects on islet development, insulin production, and glucose tolerance.
    Freemark M, Avril I, Fleenor D, Driscoll P, Petro A, Opara E, Kendall W, Oden J, Bridges S, Binart N, Breant B, Kelly PA.
    Endocrinology; 2002 Apr 13; 143(4):1378-85. PubMed ID: 11897695
    [Abstract] [Full Text] [Related]

  • 13. Human IGF binding protein-3 overexpression impairs glucose regulation in mice via an inhibition of insulin secretion.
    Nguyen KH, Yao XH, Moulik S, Mishra S, Nyomba BL.
    Endocrinology; 2011 Jun 13; 152(6):2184-96. PubMed ID: 21447640
    [Abstract] [Full Text] [Related]

  • 14. Genetic rescue of Cdk4 null mice restores pancreatic beta-cell proliferation but not homeostatic cell number.
    Martín J, Hunt SL, Dubus P, Sotillo R, Néhmé-Pélluard F, Magnuson MA, Parlow AF, Malumbres M, Ortega S, Barbacid M.
    Oncogene; 2003 Aug 14; 22(34):5261-9. PubMed ID: 12917627
    [Abstract] [Full Text] [Related]

  • 15. Transgenic mice overexpressing insulin-like growth factor-II in beta cells develop type 2 diabetes.
    Devedjian JC, George M, Casellas A, Pujol A, Visa J, Pelegrín M, Gros L, Bosch F.
    J Clin Invest; 2000 Mar 14; 105(6):731-40. PubMed ID: 10727441
    [Abstract] [Full Text] [Related]

  • 16. Bioengineered human pseudoislets form efficiently from donated tissue, compare favourably with native islets in vitro and restore normoglycaemia in mice.
    Yu Y, Gamble A, Pawlick R, Pepper AR, Salama B, Toms D, Razian G, Ellis C, Bruni A, Gala-Lopez B, Lu JL, Vovko H, Chiu C, Abdo S, Kin T, Korbutt G, Shapiro AMJ, Ungrin M.
    Diabetologia; 2018 Sep 14; 61(9):2016-2029. PubMed ID: 29971529
    [Abstract] [Full Text] [Related]

  • 17. Adenovirus-mediated hepatocyte growth factor expression in mouse islets improves pancreatic islet transplant performance and reduces beta cell death.
    Garcia-Ocana A, Takane KK, Reddy VT, Lopez-Talavera JC, Vasavada RC, Stewart AF.
    J Biol Chem; 2003 Jan 03; 278(1):343-51. PubMed ID: 12403787
    [Abstract] [Full Text] [Related]

  • 18. Increased islet cell proliferation, decreased apoptosis, and greater vascularization leading to beta-cell hyperplasia in mutant mice lacking insulin.
    Duvillié B, Currie C, Chrones T, Bucchini D, Jami J, Joshi RL, Hill DJ.
    Endocrinology; 2002 Apr 03; 143(4):1530-7. PubMed ID: 11897712
    [Abstract] [Full Text] [Related]

  • 19. Insulin secretory defects and impaired islet architecture in pancreatic beta-cell-specific STAT3 knockout mice.
    Gorogawa S, Fujitani Y, Kaneto H, Hazama Y, Watada H, Miyamoto Y, Takeda K, Akira S, Magnuson MA, Yamasaki Y, Kajimoto Y, Hori M.
    Biochem Biophys Res Commun; 2004 Jul 09; 319(4):1159-70. PubMed ID: 15194489
    [Abstract] [Full Text] [Related]

  • 20. Wide spectrum of tumors in knock-in mice carrying a Cdk4 protein insensitive to INK4 inhibitors.
    Sotillo R, Dubus P, Martín J, de la Cueva E, Ortega S, Malumbres M, Barbacid M.
    EMBO J; 2001 Dec 03; 20(23):6637-47. PubMed ID: 11726500
    [Abstract] [Full Text] [Related]


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