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218 related items for PubMed ID: 15317466

  • 1. Bile acid derivatives as ligands of the farnesoid X receptor. Synthesis, evaluation, and structure-activity relationship of a series of body and side chain modified analogues of chenodeoxycholic acid.
    Pellicciari R, Costantino G, Camaioni E, Sadeghpour BM, Entrena A, Willson TM, Fiorucci S, Clerici C, Gioiello A.
    J Med Chem; 2004 Aug 26; 47(18):4559-69. PubMed ID: 15317466
    [Abstract] [Full Text] [Related]

  • 2. Back door modulation of the farnesoid X receptor: design, synthesis, and biological evaluation of a series of side chain modified chenodeoxycholic acid derivatives.
    Pellicciari R, Gioiello A, Costantino G, Sadeghpour BM, Rizzo G, Meyer U, Parks DJ, Entrena-Guadix A, Fiorucci S.
    J Med Chem; 2006 Jul 13; 49(14):4208-15. PubMed ID: 16821780
    [Abstract] [Full Text] [Related]

  • 3. Nongenomic actions of bile acids. Synthesis and preliminary characterization of 23- and 6,23-alkyl-substituted bile acid derivatives as selective modulators for the G-protein coupled receptor TGR5.
    Pellicciari R, Sato H, Gioiello A, Costantino G, Macchiarulo A, Sadeghpour BM, Giorgi G, Schoonjans K, Auwerx J.
    J Med Chem; 2007 Sep 06; 50(18):4265-8. PubMed ID: 17685603
    [Abstract] [Full Text] [Related]

  • 4. Binding mode of 6ECDCA, a potent bile acid agonist of the farnesoid X receptor (FXR).
    Costantino G, Macchiarulo A, Entrena-Guadix A, Camaioni E, Pellicciari R.
    Bioorg Med Chem Lett; 2003 Jun 02; 13(11):1865-8. PubMed ID: 12749886
    [Abstract] [Full Text] [Related]

  • 5. The farnesoid X receptor induces very low density lipoprotein receptor gene expression.
    Sirvent A, Claudel T, Martin G, Brozek J, Kosykh V, Darteil R, Hum DW, Fruchart JC, Staels B.
    FEBS Lett; 2004 May 21; 566(1-3):173-7. PubMed ID: 15147890
    [Abstract] [Full Text] [Related]

  • 6. Targeting farnesoid X receptor for liver and metabolic disorders.
    Fiorucci S, Rizzo G, Donini A, Distrutti E, Santucci L.
    Trends Mol Med; 2007 Jul 21; 13(7):298-309. PubMed ID: 17588816
    [Abstract] [Full Text] [Related]

  • 7. 3D-QSAR studies with the aid of molecular docking for a series of non-steroidal FXR agonists.
    Zhang T, Zhou JH, Shi LW, Zhu RX, Chen MB.
    Bioorg Med Chem Lett; 2007 Apr 15; 17(8):2156-60. PubMed ID: 17307356
    [Abstract] [Full Text] [Related]

  • 8. The nuclear receptor for bile acids, FXR, transactivates human organic solute transporter-alpha and -beta genes.
    Landrier JF, Eloranta JJ, Vavricka SR, Kullak-Ublick GA.
    Am J Physiol Gastrointest Liver Physiol; 2006 Mar 15; 290(3):G476-85. PubMed ID: 16269519
    [Abstract] [Full Text] [Related]

  • 9. Knockdown of ATP8B1 expression leads to specific downregulation of the bile acid sensor FXR in HepG2 cells: effect of the FXR agonist GW4064.
    Martínez-Fernández P, Hierro L, Jara P, Alvarez L.
    Am J Physiol Gastrointest Liver Physiol; 2009 May 15; 296(5):G1119-29. PubMed ID: 19228886
    [Abstract] [Full Text] [Related]

  • 10. Discovery and optimization of non-steroidal FXR agonists from natural product-like libraries.
    Nicolaou KC, Evans RM, Roecker AJ, Hughes R, Downes M, Pfefferkorn JA.
    Org Biomol Chem; 2003 Mar 21; 1(6):908-20. PubMed ID: 12929628
    [Abstract] [Full Text] [Related]

  • 11. 6alpha-ethyl-chenodeoxycholic acid (6-ECDCA), a potent and selective FXR agonist endowed with anticholestatic activity.
    Pellicciari R, Fiorucci S, Camaioni E, Clerici C, Costantino G, Maloney PR, Morelli A, Parks DJ, Willson TM.
    J Med Chem; 2002 Aug 15; 45(17):3569-72. PubMed ID: 12166927
    [Abstract] [Full Text] [Related]

  • 12. 5Alpha-bile alcohols function as farnesoid X receptor antagonists.
    Nishimaki-Mogami T, Kawahara Y, Tamehiro N, Yoshida T, Inoue K, Ohno Y, Nagao T, Une M.
    Biochem Biophys Res Commun; 2006 Jan 06; 339(1):386-91. PubMed ID: 16300737
    [Abstract] [Full Text] [Related]

  • 13. Pyrazolidine-3,5-dione derivatives as potent non-steroidal agonists of farnesoid X receptor: virtual screening, synthesis, and biological evaluation.
    Deng G, Li W, Shen J, Jiang H, Chen K, Liu H.
    Bioorg Med Chem Lett; 2008 Oct 15; 18(20):5497-502. PubMed ID: 18815030
    [Abstract] [Full Text] [Related]

  • 14. Structure-activity relationship of bile acids and bile acid analogs in regard to FXR activation.
    Fujino T, Une M, Imanaka T, Inoue K, Nishimaki-Mogami T.
    J Lipid Res; 2004 Jan 15; 45(1):132-8. PubMed ID: 13130122
    [Abstract] [Full Text] [Related]

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  • 16. Protective effects of 6-ethyl chenodeoxycholic acid, a farnesoid X receptor ligand, in estrogen-induced cholestasis.
    Fiorucci S, Clerici C, Antonelli E, Orlandi S, Goodwin B, Sadeghpour BM, Sabatino G, Russo G, Castellani D, Willson TM, Pruzanski M, Pellicciari R, Morelli A.
    J Pharmacol Exp Ther; 2005 May 15; 313(2):604-12. PubMed ID: 15644430
    [Abstract] [Full Text] [Related]

  • 17. The farnesoid X receptor (FXR) as a new target in non-alcoholic steatohepatitis.
    Cariou B.
    Diabetes Metab; 2008 Dec 15; 34(6 Pt 2):685-91. PubMed ID: 19195631
    [Abstract] [Full Text] [Related]

  • 18. Farnesoid x receptor ligands inhibit vascular smooth muscle cell inflammation and migration.
    Li YT, Swales KE, Thomas GJ, Warner TD, Bishop-Bailey D.
    Arterioscler Thromb Vasc Biol; 2007 Dec 15; 27(12):2606-11. PubMed ID: 18029909
    [Abstract] [Full Text] [Related]

  • 19. Obeticholic acid, a synthetic bile acid agonist of the farnesoid X receptor, attenuates experimental autoimmune encephalomyelitis.
    Ho PP, Steinman L.
    Proc Natl Acad Sci U S A; 2016 Feb 09; 113(6):1600-5. PubMed ID: 26811456
    [Abstract] [Full Text] [Related]

  • 20. Role of bile acids and bile acid receptors in metabolic regulation.
    Lefebvre P, Cariou B, Lien F, Kuipers F, Staels B.
    Physiol Rev; 2009 Jan 09; 89(1):147-91. PubMed ID: 19126757
    [Abstract] [Full Text] [Related]

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