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207 related items for PubMed ID: 15319033

  • 1. Lentivirus-mediated expression of mutant MGMTP140K protects human CD34+ cells against the combined toxicity of O6-benzylguanine and 1,3-bis(2-chloroethyl)-nitrosourea or temozolomide.
    Chinnasamy D, Fairbairn LJ, Neuenfeldt J, Treisman JS, Hanson JP, Margison GP, Chinnasamy N.
    Hum Gene Ther; 2004 Aug; 15(8):758-69. PubMed ID: 15319033
    [Abstract] [Full Text] [Related]

  • 2. Simultaneous protection of G156A methylguanine DNA methyltransferase gene-transduced hematopoietic progenitors and sensitization of tumor cells using O6-benzylguanine and temozolomide.
    Reese JS, Davis BM, Liu L, Gerson SL.
    Clin Cancer Res; 1999 Jan; 5(1):163-9. PubMed ID: 9918215
    [Abstract] [Full Text] [Related]

  • 3. Chemoprotective gene transfer I: transduction of human haemopoietic progenitors with O6-benzylguanine-resistant O6-alkylguanine-DNA alkyltransferase attenuates the toxic effects of O6-alkylating agents in vitro.
    Hickson I, Fairbairn LJ, Chinnasamy N, Lashford LS, Thatcher N, Margison GP, Dexter TM, Rafferty JA.
    Gene Ther; 1998 Jun; 5(6):835-41. PubMed ID: 9747464
    [Abstract] [Full Text] [Related]

  • 4. Lentiviral transduction of P140K MGMT into human CD34(+) hematopoietic progenitors at low multiplicity of infection confers significant resistance to BG/BCNU and allows selection in vitro.
    Zielske SP, Gerson SL.
    Mol Ther; 2002 Apr; 5(4):381-7. PubMed ID: 11945064
    [Abstract] [Full Text] [Related]

  • 5. Direct reversal of DNA damage by mutant methyltransferase protein protects mice against dose-intensified chemotherapy and leads to in vivo selection of hematopoietic stem cells.
    Ragg S, Xu-Welliver M, Bailey J, D'Souza M, Cooper R, Chandra S, Seshadri R, Pegg AE, Williams DA.
    Cancer Res; 2000 Sep 15; 60(18):5187-95. PubMed ID: 11016647
    [Abstract] [Full Text] [Related]

  • 6. Selection for G156A O6-methylguanine DNA methyltransferase gene-transduced hematopoietic progenitors and protection from lethality in mice treated with O6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea.
    Davis BM, Reese JS, Koç ON, Lee K, Schupp JE, Gerson SL.
    Cancer Res; 1997 Nov 15; 57(22):5093-9. PubMed ID: 9371508
    [Abstract] [Full Text] [Related]

  • 7. Protection of committed murine haemopoietic progenitors against BCNU toxicity does not predict protection of primitive, multipotent spleen colony-forming cells - implications for chemoprotective gene therapy.
    Chinnasamy N, Rafferty J, Lashford L, Chinnasamy D, Margison G, Thatcher N, Dexter T, Fairbairn L.
    Leukemia; 1999 Nov 15; 13(11):1776-83. PubMed ID: 10557052
    [Abstract] [Full Text] [Related]

  • 8. In vivo selection of MGMT(P140K) lentivirus-transduced human NOD/SCID repopulating cells without pretransplant irradiation conditioning.
    Zielske SP, Reese JS, Lingas KT, Donze JR, Gerson SL.
    J Clin Invest; 2003 Nov 15; 112(10):1561-70. PubMed ID: 14617757
    [Abstract] [Full Text] [Related]

  • 9. Chemoprotective gene transfer II: multilineage in vivo protection of haemopoiesis against the effects of an antitumour agent by expression of a mutant human O6-alkylguanine-DNA alkyltransferase.
    Chinnasamy N, Rafferty JA, Hickson I, Lashford LS, Longhurst SJ, Thatcher N, Margison GP, Dexter TM, Fairbairn LJ.
    Gene Ther; 1998 Jun 15; 5(6):842-7. PubMed ID: 9747465
    [Abstract] [Full Text] [Related]

  • 10. Differential competitive resistance to methylating versus chloroethylating agents among five O6-alkylguanine DNA alkyltransferases in human hematopoietic cells.
    Fontes AM, Davis BM, Encell LP, Lingas K, Covas DT, Zago MA, Loeb LA, Pegg AE, Gerson SL.
    Mol Cancer Ther; 2006 Jan 15; 5(1):121-8. PubMed ID: 16432170
    [Abstract] [Full Text] [Related]

  • 11. Human long-term culture initiating cells are sensitive to benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea and protected after mutant (G156A) methylguanine methyltransferase gene transfer.
    Koç ON, Reese JS, Szekely EM, Gerson SL.
    Cancer Gene Ther; 1999 Jan 15; 6(4):340-8. PubMed ID: 10419052
    [Abstract] [Full Text] [Related]

  • 12. Mitochondrial targeting of human O6-methylguanine DNA methyltransferase protects against cell killing by chemotherapeutic alkylating agents.
    Cai S, Xu Y, Cooper RJ, Ferkowicz MJ, Hartwell JR, Pollok KE, Kelley MR.
    Cancer Res; 2005 Apr 15; 65(8):3319-27. PubMed ID: 15833865
    [Abstract] [Full Text] [Related]

  • 13. In vivo selection of hematopoietic progenitor cells and temozolomide dose intensification in rhesus macaques through lentiviral transduction with a drug resistance gene.
    Larochelle A, Choi U, Shou Y, Naumann N, Loktionova NA, Clevenger JR, Krouse A, Metzger M, Donahue RE, Kang E, Stewart C, Persons D, Malech HL, Dunbar CE, Sorrentino BP.
    J Clin Invest; 2009 Jul 15; 119(7):1952-63. PubMed ID: 19509470
    [Abstract] [Full Text] [Related]

  • 14. Chemoprotection of human hematopoietic stem cells by simultaneous lentiviral overexpression of multidrug resistance 1 and O(6)-methylguanine-DNA methyltransferase(P140K).
    Maier P, Spier I, Laufs S, Veldwijk MR, Fruehauf S, Wenz F, Zeller WJ.
    Gene Ther; 2010 Mar 15; 17(3):389-99. PubMed ID: 19865182
    [Abstract] [Full Text] [Related]

  • 15. Retroviral transduction of a mutant methylguanine DNA methyltransferase gene into human CD34 cells confers resistance to O6-benzylguanine plus 1,3-bis(2-chloroethyl)-1-nitrosourea.
    Reese JS, Koç ON, Lee KM, Liu L, Allay JA, Phillips WP, Gerson SL.
    Proc Natl Acad Sci U S A; 1996 Nov 26; 93(24):14088-93. PubMed ID: 8943065
    [Abstract] [Full Text] [Related]

  • 16. Human mesenchymal stem cells provide stromal support for efficient CD34+ transduction.
    Reese JS, Koç ON, Gerson SL.
    J Hematother Stem Cell Res; 1999 Oct 26; 8(5):515-23. PubMed ID: 10791902
    [Abstract] [Full Text] [Related]

  • 17. Human CD34+ hematopoietic progenitors have low, cytokine-unresponsive O6-alkylguanine-DNA alkyltransferase and are sensitive to O6-benzylguanine plus BCNU.
    Gerson SL, Phillips W, Kastan M, Dumenco LL, Donovan C.
    Blood; 1996 Sep 01; 88(5):1649-55. PubMed ID: 8781420
    [Abstract] [Full Text] [Related]

  • 18. Protection of hematopoietic cells from O(6)-alkylation damage by O(6)-methylguanine DNA methyltransferase gene transfer: studies with different O(6)-alkylating agents and retroviral backbones.
    Jansen M, Bardenheuer W, Sorg UR, Seeber S, Flasshove M, Moritz T.
    Eur J Haematol; 2001 Jul 01; 67(1):2-13. PubMed ID: 11553261
    [Abstract] [Full Text] [Related]

  • 19. O6-Benzylguanine potentiates BCNU but not busulfan toxicity in hematopoietic stem cells.
    Westerhof GR, Down JD, Blokland I, Wood M, Boudewijn A, Watson AJ, McGown AT, Ploemacher RE, Margison GP.
    Exp Hematol; 2001 May 01; 29(5):633-8. PubMed ID: 11376877
    [Abstract] [Full Text] [Related]

  • 20. In vivo selection for human and murine hematopoietic cells transduced with a therapeutic MGMT lentiviral vector that inhibits HIV replication.
    Davis BM, Humeau L, Dropulic B.
    Mol Ther; 2004 Feb 01; 9(2):160-72. PubMed ID: 14759800
    [Abstract] [Full Text] [Related]

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