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Journal Abstract Search

274 related items for PubMed ID: 15324876

  • 1. Spiroquinazolinones as novel, potent, and selective PDE7 inhibitors. Part 1.
    Lorthiois E, Bernardelli P, Vergne F, Oliveira C, Mafroud AK, Proust E, Heuze L, Moreau F, Idrissi M, Tertre A, Bertin B, Coupe M, Wrigglesworth R, Descours A, Soulard P, Berna P.
    Bioorg Med Chem Lett; 2004 Sep 20; 14(18):4623-6. PubMed ID: 15324876
    [Abstract] [Full Text] [Related]

  • 2. Spiroquinazolinones as novel, potent, and selective PDE7 inhibitors. Part 2: Optimization of 5,8-disubstituted derivatives.
    Bernardelli P, Lorthiois E, Vergne F, Oliveira C, Mafroud AK, Proust E, Pham N, Ducrot P, Moreau F, Idrissi M, Tertre A, Bertin B, Coupe M, Chevalier E, Descours A, Berlioz-Seux F, Berna P, Li M.
    Bioorg Med Chem Lett; 2004 Sep 20; 14(18):4627-31. PubMed ID: 15324877
    [Abstract] [Full Text] [Related]

  • 3. Discovery of thiadiazoles as a novel structural class of potent and selective PDE7 inhibitors. Part 1: design, synthesis and structure-activity relationship studies.
    Vergne F, Bernardelli P, Lorthiois E, Pham N, Proust E, Oliveira C, Mafroud AK, Royer F, Wrigglesworth R, Schellhaas J, Barvian M, Moreau F, Idrissi M, Tertre A, Bertin B, Coupe M, Berna P, Soulard P.
    Bioorg Med Chem Lett; 2004 Sep 20; 14(18):4607-13. PubMed ID: 15324874
    [Abstract] [Full Text] [Related]

  • 4. Fused pyrimidine based inhibitors of phosphodiesterase 7 (PDE7): synthesis and initial structure-activity relationships.
    Kempson J, Pitts WJ, Barbosa J, Guo J, Omotoso O, Watson A, Stebbins K, Starling GC, Dodd JH, Barrish JC, Felix R, Fischer K.
    Bioorg Med Chem Lett; 2005 Apr 01; 15(7):1829-33. PubMed ID: 15780616
    [Abstract] [Full Text] [Related]

  • 5. Discovery of thiadiazoles as a novel structural class of potent and selective PDE7 inhibitors. Part 2: metabolism-directed optimization studies towards orally bioavailable derivatives.
    Vergne F, Bernardelli P, Lorthiois E, Pham N, Proust E, Oliveira C, Mafroud AK, Ducrot P, Wrigglesworth R, Berlioz-Seux F, Coleon F, Chevalier E, Moreau F, Idrissi M, Tertre A, Descours A, Berna P, Li M.
    Bioorg Med Chem Lett; 2004 Sep 20; 14(18):4615-21. PubMed ID: 15324875
    [Abstract] [Full Text] [Related]

  • 6. Syntheses and evaluation of pyrido[2,3-dlpyrimidine-2,4-diones as PDE 4 inhibitors.
    Nam G, Yoon CM, Kim E, Rhee CK, Kim JH, Shin JH, Kim SH.
    Bioorg Med Chem Lett; 2001 Mar 12; 11(5):611-4. PubMed ID: 11266153
    [Abstract] [Full Text] [Related]

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  • 8. Identification of purine inhibitors of phosphodiesterase 7 (PDE7).
    Pitts WJ, Vaccaro W, Huynh T, Leftheris K, Roberge JY, Barbosa J, Guo J, Brown B, Watson A, Donaldson K, Starling GC, Kiener PA, Poss MA, Dodd JH, Barrish JC.
    Bioorg Med Chem Lett; 2004 Jun 07; 14(11):2955-8. PubMed ID: 15125967
    [Abstract] [Full Text] [Related]

  • 9. QSAR study of phosphodiesterase inhibitory activity of imidazo[2,1-b]-quinazolines: active site analysis.
    Prabhakar YS.
    Drug Des Deliv; 1989 Dec 07; 5(2):81-91. PubMed ID: 2577989
    [Abstract] [Full Text] [Related]

  • 10. Quinazolines: combined type 3 and 4 phosphodiesterase inhibitors.
    Charpiot B, Brun J, Donze I, Naef R, Stefani M, Mueller T.
    Bioorg Med Chem Lett; 1998 Oct 20; 8(20):2891-6. PubMed ID: 9873643
    [Abstract] [Full Text] [Related]

  • 11. Identification of potent pyrimidine inhibitors of phosphodiesterase 7 (PDE7) and their ability to inhibit T cell proliferation.
    Guo J, Watson A, Kempson J, Carlsen M, Barbosa J, Stebbins K, Lee D, Dodd J, Nadler SG, McKinnon M, Barrish J, Pitts WJ.
    Bioorg Med Chem Lett; 2009 Apr 01; 19(7):1935-8. PubMed ID: 19272774
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  • 12.
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  • 13. Synthesis and evaluation of quinazoline derivatives as phosphodiesterase 7 inhibitors.
    Sánchez AI, Martínez-Barrasa V, Burgos C, Vaquero JJ, Alvarez-Builla J, Terricabras E, Segarra V.
    Bioorg Med Chem; 2013 Apr 15; 21(8):2370-2378. PubMed ID: 23454131
    [Abstract] [Full Text] [Related]

  • 14. Design, synthesis, and biological activities of new thieno[3,2-d] pyrimidines as selective type 4 phosphodiesterase inhibitors.
    Crespo MI, Pagès L, Vega A, Segarra V, López M, Doménech T, Miralpeix M, Beleta J, Ryder H, Palacios JM.
    J Med Chem; 1998 Oct 08; 41(21):4021-35. PubMed ID: 9767640
    [Abstract] [Full Text] [Related]

  • 15. Synthesis, biological evaluation and molecular modelling studies on benzothiadiazine derivatives as PDE4 selective inhibitors.
    Tait A, Luppi A, Hatzelmann A, Fossa P, Mosti L.
    Bioorg Med Chem; 2005 Feb 15; 13(4):1393-402. PubMed ID: 15670947
    [Abstract] [Full Text] [Related]

  • 16. Cyclic nucleotide phosphodiesterases (PDEs) in human osteoblastic cells; the effect of PDE inhibition on cAMP accumulation.
    Ahlström M, Pekkinen M, Huttunen M, Lamberg-Allardt C.
    Cell Mol Biol Lett; 2005 Feb 15; 10(2):305-19. PubMed ID: 16010295
    [Abstract] [Full Text] [Related]

  • 17. Synthesis of 7-benzylamino-6-chloro-2-piperazino-4-pyrrolidinopteridine and novel derivatives free of positional isomers. Potent inhibitors of cAMP-specific phosphodiesterase and of malignant tumor cell growth.
    Merz KH, Marko D, Regiert T, Reiss G, Frank W, Eisenbrand G.
    J Med Chem; 1998 Nov 19; 41(24):4733-43. PubMed ID: 9822544
    [Abstract] [Full Text] [Related]

  • 18. Inhibitory effects of flavonoids on phosphodiesterase isozymes from guinea pig and their structure-activity relationships.
    Ko WC, Shih CM, Lai YH, Chen JH, Huang HL.
    Biochem Pharmacol; 2004 Nov 15; 68(10):2087-94. PubMed ID: 15476679
    [Abstract] [Full Text] [Related]

  • 19. Novel cyclic compounds as potent phosphodiesterase 4 inhibitors.
    He W, Huang FC, Hanney B, Souness J, Miller B, Liang G, Mason J, Djuric S.
    J Med Chem; 1998 Oct 22; 41(22):4216-23. PubMed ID: 9784096
    [Abstract] [Full Text] [Related]

  • 20. Potent tetracyclic guanine inhibitors of PDE1 and PDE5 cyclic guanosine monophosphate phosphodiesterases with oral antihypertensive activity.
    Ahn HS, Bercovici A, Boykow G, Bronnenkant A, Chackalamannil S, Chow J, Cleven R, Cook J, Czarniecki M, Domalski C, Fawzi A, Green M, Gündes A, Ho G, Laudicina M, Lindo N, Ma K, Manna M, McKittrick B, Mirzai B, Nechuta T, Neustadt B, Puchalski C, Pula K, Zhang H.
    J Med Chem; 1997 Jul 04; 40(14):2196-210. PubMed ID: 9216839
    [Abstract] [Full Text] [Related]

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