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Journal Abstract Search

733 related items for PubMed ID: 15324879

  • 1. Synthesis and evaluation of tacrine-E2020 hybrids as acetylcholinesterase inhibitors for the treatment of Alzheimer's disease.
    Shao D, Zou C, Luo C, Tang X, Li Y.
    Bioorg Med Chem Lett; 2004 Sep 20; 14(18):4639-42. PubMed ID: 15324879
    [Abstract] [Full Text] [Related]

  • 2. Donepezil-tacrine hybrid related derivatives as new dual binding site inhibitors of AChE.
    Alonso D, Dorronsoro I, Rubio L, Muñoz P, García-Palomero E, Del Monte M, Bidon-Chanal A, Orozco M, Luque FJ, Castro A, Medina M, Martínez A.
    Bioorg Med Chem; 2005 Dec 15; 13(24):6588-97. PubMed ID: 16230018
    [Abstract] [Full Text] [Related]

  • 3. Rational approach to discover multipotent anti-Alzheimer drugs.
    Rosini M, Andrisano V, Bartolini M, Bolognesi ML, Hrelia P, Minarini A, Tarozzi A, Melchiorre C.
    J Med Chem; 2005 Jan 27; 48(2):360-3. PubMed ID: 15658850
    [Abstract] [Full Text] [Related]

  • 4. Synthesis, biological evaluation, and molecular modeling of donepezil and N-[(5-(benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine hybrids as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's disease.
    Bolea I, Juárez-Jiménez J, de Los Ríos C, Chioua M, Pouplana R, Luque FJ, Unzeta M, Marco-Contelles J, Samadi A.
    J Med Chem; 2011 Dec 22; 54(24):8251-70. PubMed ID: 22023459
    [Abstract] [Full Text] [Related]

  • 5. Synthesis and in vitro evaluation of N-alkyl-7-methoxytacrine hydrochlorides as potential cholinesterase inhibitors in Alzheimer disease.
    Korabecny J, Musilek K, Holas O, Binder J, Zemek F, Marek J, Pohanka M, Opletalova V, Dohnal V, Kuca K.
    Bioorg Med Chem Lett; 2010 Oct 15; 20(20):6093-5. PubMed ID: 20817518
    [Abstract] [Full Text] [Related]

  • 6. Design, synthesis, and biological evaluation of dual binding site acetylcholinesterase inhibitors: new disease-modifying agents for Alzheimer's disease.
    Muñoz-Ruiz P, Rubio L, García-Palomero E, Dorronsoro I, del Monte-Millán M, Valenzuela R, Usán P, de Austria C, Bartolini M, Andrisano V, Bidon-Chanal A, Orozco M, Luque FJ, Medina M, Martínez A.
    J Med Chem; 2005 Nov 17; 48(23):7223-33. PubMed ID: 16279781
    [Abstract] [Full Text] [Related]

  • 7. Synthesis, in vitro pharmacology, and molecular modeling of very potent tacrine-huperzine A hybrids as acetylcholinesterase inhibitors of potential interest for the treatment of Alzheimer's disease.
    Camps P, El Achab R, Görbig DM, Morral J, Muñoz-Torrero D, Badia A, Eladi Baños J, Vivas NM, Barril X, Orozco M, Luque FJ.
    J Med Chem; 1999 Aug 26; 42(17):3227-42. PubMed ID: 10464010
    [Abstract] [Full Text] [Related]

  • 8. Novel donepezil-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation.
    Camps P, Formosa X, Galdeano C, Gómez T, Muñoz-Torrero D, Scarpellini M, Viayna E, Badia A, Clos MV, Camins A, Pallàs M, Bartolini M, Mancini F, Andrisano V, Estelrich J, Lizondo M, Bidon-Chanal A, Luque FJ.
    J Med Chem; 2008 Jun 26; 51(12):3588-98. PubMed ID: 18517184
    [Abstract] [Full Text] [Related]

  • 9. Synthesis and biological activity of new donepezil-hydrazinonicotinamide hybrids.
    Zurek E, Szymański P, Mikiciuk-Olasik E.
    Drug Res (Stuttg); 2013 Mar 26; 63(3):137-44. PubMed ID: 23447117
    [Abstract] [Full Text] [Related]

  • 10. Tacrine-based dual binding site acetylcholinesterase inhibitors as potential disease-modifying anti-Alzheimer drug candidates.
    Camps P, Formosa X, Galdeano C, Gómez T, Muñoz-Torrero D, Ramírez L, Viayna E, Gómez E, Isambert N, Lavilla R, Badia A, Clos MV, Bartolini M, Mancini F, Andrisano V, Bidon-Chanal A, Huertas O, Dafni T, Luque FJ.
    Chem Biol Interact; 2010 Sep 06; 187(1-3):411-5. PubMed ID: 20167211
    [Abstract] [Full Text] [Related]

  • 11. 7-MEOTA-donepezil like compounds as cholinesterase inhibitors: Synthesis, pharmacological evaluation, molecular modeling and QSAR studies.
    Korabecny J, Dolezal R, Cabelova P, Horova A, Hruba E, Ricny J, Sedlacek L, Nepovimova E, Spilovska K, Andrs M, Musilek K, Opletalova V, Sepsova V, Ripova D, Kuca K.
    Eur J Med Chem; 2014 Jul 23; 82():426-38. PubMed ID: 24929293
    [Abstract] [Full Text] [Related]

  • 12. [Development of donepezil hydrochloride (Aricept) for the treatment of Alzheimer's disease].
    Yamanishi Y, Ogura H, Kosasa T.
    Tanpakushitsu Kakusan Koso; 2000 Apr 23; 45(6 Suppl):1047-51. PubMed ID: 10771671
    [No Abstract] [Full Text] [Related]

  • 13. Anticholinesterase effects of huperzine A, E2020, and tacrine in rats.
    Wang H, Tang XC.
    Zhongguo Yao Li Xue Bao; 1998 Jan 23; 19(1):27-30. PubMed ID: 10375753
    [Abstract] [Full Text] [Related]

  • 14. Synthesis, in vitro assay, and molecular modeling of new piperidine derivatives having dual inhibitory potency against acetylcholinesterase and Abeta1-42 aggregation for Alzheimer's disease therapeutics.
    Kwon YE, Park JY, No KT, Shin JH, Lee SK, Eun JS, Yang JH, Shin TY, Kim DK, Chae BS, Leem JY, Kim KH.
    Bioorg Med Chem; 2007 Oct 15; 15(20):6596-607. PubMed ID: 17681794
    [Abstract] [Full Text] [Related]

  • 15. Synthesis and biological evaluation of tacrine-thiadiazolidinone hybrids as dual acetylcholinesterase inhibitors.
    Dorronsoro I, Alonso D, Castro A, del Monte M, García-Palomero E, Martínez A.
    Arch Pharm (Weinheim); 2005 Jan 15; 338(1):18-23. PubMed ID: 15674800
    [Abstract] [Full Text] [Related]

  • 16. Design and synthesis of tacrine-ferulic acid hybrids as multi-potent anti-Alzheimer drug candidates.
    Fang L, Kraus B, Lehmann J, Heilmann J, Zhang Y, Decker M.
    Bioorg Med Chem Lett; 2008 May 01; 18(9):2905-9. PubMed ID: 18406135
    [Abstract] [Full Text] [Related]

  • 17. Design, synthesis and biological evaluation of new 2-benzoxazolinone derivatives as potential cholinesterase inhibitors for therapy of alzheimer's disease.
    Szymański P, Janik A, Zurek E, Mikiciuk-Olasik E.
    Pharmazie; 2011 Jun 01; 66(6):399-403. PubMed ID: 21699076
    [Abstract] [Full Text] [Related]

  • 18. Molecular modeling, docking and ADMET studies applied to the design of a novel hybrid for treatment of Alzheimer's disease.
    da Silva CH, Campo VL, Carvalho I, Taft CA.
    J Mol Graph Model; 2006 Oct 01; 25(2):169-75. PubMed ID: 16413803
    [Abstract] [Full Text] [Related]

  • 19. Design, synthesis and evaluation of tacrine-flurbiprofen-nitrate trihybrids as novel anti-Alzheimer's disease agents.
    Chen Y, Sun J, Huang Z, Liao H, Peng S, Lehmann J, Zhang Y.
    Bioorg Med Chem; 2013 May 01; 21(9):2462-70. PubMed ID: 23541836
    [Abstract] [Full Text] [Related]

  • 20. Synthesis and biological evaluation of NO-donor-tacrine hybrids as hepatoprotective anti-Alzheimer drug candidates.
    Fang L, Appenroth D, Decker M, Kiehntopf M, Roegler C, Deufel T, Fleck C, Peng S, Zhang Y, Lehmann J.
    J Med Chem; 2008 Feb 28; 51(4):713-6. PubMed ID: 18232655
    [Abstract] [Full Text] [Related]

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