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Journal Abstract Search

445 related items for PubMed ID: 15341524

  • 1. PEN-2 enhances gamma-cleavage after presenilin heterodimer formation.
    Shiraishi H, Sai X, Wang HQ, Maeda Y, Kurono Y, Nishimura M, Yanagisawa K, Komano H.
    J Neurochem; 2004 Sep; 90(6):1402-13. PubMed ID: 15341524
    [Abstract] [Full Text] [Related]

  • 2. Co-expressed presenilin 1 NTF and CTF form functional gamma-secretase complexes in cells devoid of full-length protein.
    Laudon H, Mathews PM, Karlström H, Bergman A, Farmery MR, Nixon RA, Winblad B, Gandy SE, Lendahl U, Lundkvist J, Näslund J.
    J Neurochem; 2004 Apr; 89(1):44-53. PubMed ID: 15030388
    [Abstract] [Full Text] [Related]

  • 3. gamma-Secretase complexes containing N- and C-terminal fragments of different presenilin origin retain normal gamma-secretase activity.
    Strömberg K, Hansson EM, Laudon H, Bergstedt S, Näslund J, Lundkvist J, Lendahl U.
    J Neurochem; 2005 Nov; 95(3):880-90. PubMed ID: 16135086
    [Abstract] [Full Text] [Related]

  • 4. Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms.
    Bentahir M, Nyabi O, Verhamme J, Tolia A, Horré K, Wiltfang J, Esselmann H, De Strooper B.
    J Neurochem; 2006 Feb; 96(3):732-42. PubMed ID: 16405513
    [Abstract] [Full Text] [Related]

  • 5. Detergent-dependent dissociation of active gamma-secretase reveals an interaction between Pen-2 and PS1-NTF and offers a model for subunit organization within the complex.
    Fraering PC, LaVoie MJ, Ye W, Ostaszewski BL, Kimberly WT, Selkoe DJ, Wolfe MS.
    Biochemistry; 2004 Jan 20; 43(2):323-33. PubMed ID: 14717586
    [Abstract] [Full Text] [Related]

  • 6. Pharmacological evidences for DFK167-sensitive presenilin-independent gamma-secretase-like activity.
    Sevalle J, Ayral E, Hernandez JF, Martinez J, Checler F.
    J Neurochem; 2009 Jul 20; 110(1):275-83. PubMed ID: 19457123
    [Abstract] [Full Text] [Related]

  • 7. Reconstitution of gamma-secretase by truncated presenilin (PS) fragments revealed that PS C-terminal transmembrane domain is critical for formation of gamma-secretase complex.
    Shiraishi H, Marutani T, Wang HQ, Maeda Y, Kurono Y, Takashima A, Araki W, Nishimura M, Yanagisawa K, Komano H.
    Genes Cells; 2006 Jan 20; 11(1):83-93. PubMed ID: 16371134
    [Abstract] [Full Text] [Related]

  • 8. Syntaxin 5 interacts specifically with presenilin holoproteins and affects processing of betaAPP in neuronal cells.
    Suga K, Saito A, Tomiyama T, Mori H, Akagawa K.
    J Neurochem; 2005 Jul 20; 94(2):425-39. PubMed ID: 15998293
    [Abstract] [Full Text] [Related]

  • 9. A presenilin-independent aspartyl protease prefers the gamma-42 site cleavage.
    Lai MT, Crouthamel MC, DiMuzio J, Pietrak BL, Donoviel DB, Bernstein A, Gardell SJ, Li YM, Hazuda D.
    J Neurochem; 2006 Jan 20; 96(1):118-25. PubMed ID: 16300640
    [Abstract] [Full Text] [Related]

  • 10. C-terminal PAL motif of presenilin and presenilin homologues required for normal active site conformation.
    Wang J, Beher D, Nyborg AC, Shearman MS, Golde TE, Goate A.
    J Neurochem; 2006 Jan 20; 96(1):218-27. PubMed ID: 16305624
    [Abstract] [Full Text] [Related]

  • 11. Presenilin modulates Pen-2 levels posttranslationally by protecting it from proteasomal degradation.
    Crystal AS, Morais VA, Fortna RR, Carlin D, Pierson TC, Wilson CA, Lee VM, Doms RW.
    Biochemistry; 2004 Mar 30; 43(12):3555-63. PubMed ID: 15035625
    [Abstract] [Full Text] [Related]

  • 12. Length and overall sequence of the PEN-2 C-terminal domain determines its function in the stabilization of presenilin fragments.
    Prokop S, Haass C, Steiner H.
    J Neurochem; 2005 Jul 30; 94(1):57-62. PubMed ID: 15953349
    [Abstract] [Full Text] [Related]

  • 13. Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity.
    Wolfe MS, Xia W, Ostaszewski BL, Diehl TS, Kimberly WT, Selkoe DJ.
    Nature; 1999 Apr 08; 398(6727):513-7. PubMed ID: 10206644
    [Abstract] [Full Text] [Related]

  • 14. Immature nicastrin stabilizes APH-1 independent of PEN-2 and presenilin: identification of nicastrin mutants that selectively interact with APH-1.
    Shirotani K, Edbauer D, Kostka M, Steiner H, Haass C.
    J Neurochem; 2004 Jun 08; 89(6):1520-7. PubMed ID: 15189355
    [Abstract] [Full Text] [Related]

  • 15. Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane.
    Kaether C, Lammich S, Edbauer D, Ertl M, Rietdorf J, Capell A, Steiner H, Haass C.
    J Cell Biol; 2002 Aug 05; 158(3):551-61. PubMed ID: 12147673
    [Abstract] [Full Text] [Related]

  • 16. Transition-state analogue gamma-secretase inhibitors stabilize a 900 kDa presenilin/nicastrin complex.
    Evin G, Canterford LD, Hoke DE, Sharples RA, Culvenor JG, Masters CL.
    Biochemistry; 2005 Mar 22; 44(11):4332-41. PubMed ID: 15766262
    [Abstract] [Full Text] [Related]

  • 17. Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation.
    Edbauer D, Winkler E, Haass C, Steiner H.
    Proc Natl Acad Sci U S A; 2002 Jun 25; 99(13):8666-71. PubMed ID: 12048259
    [Abstract] [Full Text] [Related]

  • 18. Beta-amyloid secretases and beta-amloid degrading enzyme expression in lens.
    Li G, Percontino L, Sun Q, Qazi AS, Frederikse PH.
    Mol Vis; 2003 May 01; 9():179-83. PubMed ID: 12740567
    [Abstract] [Full Text] [Related]

  • 19. Ubiquilin regulates presenilin endoproteolysis and modulates gamma-secretase components, Pen-2 and nicastrin.
    Massey LK, Mah AL, Monteiro MJ.
    Biochem J; 2005 Nov 01; 391(Pt 3):513-25. PubMed ID: 15975090
    [Abstract] [Full Text] [Related]

  • 20. Phosphorylation of amyloid precursor carboxy-terminal fragments enhances their processing by a gamma-secretase-dependent mechanism.
    Vingtdeux V, Hamdane M, Gompel M, Bégard S, Drobecq H, Ghestem A, Grosjean ME, Kostanjevecki V, Grognet P, Vanmechelen E, Buée L, Delacourte A, Sergeant N.
    Neurobiol Dis; 2005 Nov 01; 20(2):625-37. PubMed ID: 15936948
    [Abstract] [Full Text] [Related]

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