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303 related items for PubMed ID: 15351401

  • 21. Synthesis of new serotonin 5-HT7 receptor ligands. Determinants of 5-HT7/5-HT1A receptor selectivity.
    Medina RA, Sallander J, Benhamú B, Porras E, Campillo M, Pardo L, López-Rodríguez ML.
    J Med Chem; 2009 Apr 23; 52(8):2384-92. PubMed ID: 19326916
    [Abstract] [Full Text] [Related]

  • 22. Structure-intrinsic activity relationship studies in the group of 1-imido/amido substituted 4-(4-arylpiperazin-1-yl)cyclohexane derivatives; new, potent 5-HT1A receptor agents with anxiolytic- like activity.
    Bojarski AJ, Paluchowska MH, Duszyńska B, Bugno R, Kłodzińska A, Tatarczyńska E, Chojnacka-Wójcik E.
    Bioorg Med Chem; 2006 Mar 01; 14(5):1391-402. PubMed ID: 16266808
    [Abstract] [Full Text] [Related]

  • 23. Further studies on the interaction of the 5-hydroxytryptamine3 (5-HT3) receptor with arylpiperazine ligands. development of a new 5-HT3 receptor ligand showing potent acetylcholinesterase inhibitory properties.
    Cappelli A, Gallelli A, Manini M, Anzini M, Mennuni L, Makovec F, Menziani MC, Alcaro S, Ortuso F, Vomero S.
    J Med Chem; 2005 May 19; 48(10):3564-75. PubMed ID: 15887964
    [Abstract] [Full Text] [Related]

  • 24. New 2-piperazinylbenzimidazole derivatives as 5-HT3 antagonists. Synthesis and pharmacological evaluation.
    Orjales A, Mosquera R, Labeaga L, Rodes R.
    J Med Chem; 1997 Feb 14; 40(4):586-93. PubMed ID: 9046349
    [Abstract] [Full Text] [Related]

  • 25. Novel potent and selective central 5-HT3 receptor ligands provided with different intrinsic efficacy. 1. Mapping the central 5-HT3 receptor binding site by arylpiperazine derivatives.
    Cappelli A, Anzini M, Vomero S, Mennuni L, Makovec F, Doucet E, Hamon M, Bruni G, Romeo MR, Menziani MC, De Benedetti PG, Langer T.
    J Med Chem; 1998 Feb 26; 41(5):728-41. PubMed ID: 9513601
    [Abstract] [Full Text] [Related]

  • 26. New 4-[omega-(diarylmethylamino)alkyl]- and 4-[omega-(diarylmethoxy)alkyl]-1-arylpiperazines as selective 5-HT1A/5-HT2A receptor ligands with differentiated in vivo activity.
    Paluchowska MH, Charakchieva-Minol S, Tatarczyńska E, Kłodzińska A, Stachowicz K, Chojnacka-Wójcik E.
    Pol J Pharmacol; 2004 Feb 26; 56(6):743-54. PubMed ID: 15662087
    [Abstract] [Full Text] [Related]

  • 27. New 5-HT(1A) receptor ligands containing a N'-cyanoisonicotinamidine nucleus: synthesis and in vitro pharmacological evaluation.
    Fiorino F, Severino B, De Angelis F, Perissutti E, Magli E, Frecentese F, Esposito A, Massarelli P, Nencini C, Santagada V, Caliendo G.
    Bioorg Med Chem Lett; 2010 May 01; 20(9):2978-82. PubMed ID: 20347301
    [Abstract] [Full Text] [Related]

  • 28. Lecozotan (SRA-333): a selective serotonin 1A receptor antagonist that enhances the stimulated release of glutamate and acetylcholine in the hippocampus and possesses cognitive-enhancing properties.
    Schechter LE, Smith DL, Rosenzweig-Lipson S, Sukoff SJ, Dawson LA, Marquis K, Jones D, Piesla M, Andree T, Nawoschik S, Harder JA, Womack MD, Buccafusco J, Terry AV, Hoebel B, Rada P, Kelly M, Abou-Gharbia M, Barrett JE, Childers W.
    J Pharmacol Exp Ther; 2005 Sep 01; 314(3):1274-89. PubMed ID: 15951399
    [Abstract] [Full Text] [Related]

  • 29. Serotonin 5-HT receptor blockade enhances Ca(2+)/calmodulin-dependent protein kinase II function and membrane expression of AMPA receptor subunits in the rat hippocampus: implications for memory formation.
    Schiapparelli L, Del Río J, Frechilla D.
    J Neurochem; 2005 Aug 01; 94(4):884-95. PubMed ID: 16092936
    [Abstract] [Full Text] [Related]

  • 30. Anxiolytic-like effect of a serotonergic ligand with high affinity for 5-HT1A, 5-HT2A and 5-HT3 receptors.
    Delgado M, Caicoya AG, Greciano V, Benhamú B, López-Rodríguez ML, Fernández-Alfonso MS, Pozo MA, Manzanares J, Fuentes JA.
    Eur J Pharmacol; 2005 Mar 21; 511(1):9-19. PubMed ID: 15777774
    [Abstract] [Full Text] [Related]

  • 31. N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-nitrophenyl) cyclohexanecarboxamide: a novel pre- and postsynaptic 5-hydroxytryptamine(1A) receptor antagonist active on the lower urinary tract.
    Leonardi A, Guarneri L, Poggesi E, Angelico P, Velasco C, Cilia A, Testa R.
    J Pharmacol Exp Ther; 2001 Dec 21; 299(3):1027-37. PubMed ID: 11714892
    [Abstract] [Full Text] [Related]

  • 32. A new class of arylpiperazine derivatives: the library synthesis on SynPhase lanterns and biological evaluation on serotonin 5-HT(1A) and 5-HT(2A) receptors.
    Zajdel P, Subra G, Bojarski AJ, Duszyńska B, Pawłowski M, Martinez J.
    J Comb Chem; 2004 Dec 21; 6(5):761-7. PubMed ID: 15360211
    [Abstract] [Full Text] [Related]

  • 33. Discovery of a novel 5-HT(3) antagonist/5-HT(1A) agonist 3-amino-5,6,7,8-tetrahydro-2-{4-[4-(quinolin-2-yl)piperazin-1-yl]butyl}quinazolin-4(3H)-one (TZB-30878) as an orally bioavailable agent for irritable bowel syndrome.
    Asagarasu A, Matsui T, Hayashi H, Tamaoki S, Yamauchi Y, Minato K, Sato M.
    J Med Chem; 2010 Nov 11; 53(21):7549-63. PubMed ID: 20931963
    [Abstract] [Full Text] [Related]

  • 34. The influence of modifications in imide fragment structure on 5-HT(1A) and 5-HT(7) receptor affinity and in vivo pharmacological properties of some new 1-(m-trifluoromethylphenyl)piperazines.
    Paluchowska MH, Bugno R, Duszyńska B, Tatarczyńska E, Nikiforuk A, Lenda T, Chojnacka-Wójcik E.
    Bioorg Med Chem; 2007 Nov 15; 15(22):7116-25. PubMed ID: 17825569
    [Abstract] [Full Text] [Related]

  • 35. In vitro characterization of SLV308 (7-[4-methyl-1-piperazinyl]-2(3H)-benzoxazolone, monohydrochloride): a novel partial dopamine D2 and D3 receptor agonist and serotonin 5-HT1A receptor agonist.
    Glennon JC, Van Scharrenburg G, Ronken E, Hesselink MB, Reinders JH, Van Der Neut M, Long SK, Feenstra RW, McCreary AC.
    Synapse; 2006 Dec 15; 60(8):599-608. PubMed ID: 17001660
    [Abstract] [Full Text] [Related]

  • 36. Synthesis of dihydrofuroaporphine derivatives: identification of a potent and selective serotonin 5-HT 1A receptor agonist.
    Liu Z, Zhang H, Ye N, Zhang J, Wu Q, Sun P, Li L, Zhen X, Zhang A.
    J Med Chem; 2010 Feb 11; 53(3):1319-28. PubMed ID: 20041669
    [Abstract] [Full Text] [Related]

  • 37. Synthesis and structure-activity relationships of a new model of arylpiperazines. 8. Computational simulation of ligand-receptor interaction of 5-HT(1A)R agonists with selectivity over alpha1-adrenoceptors.
    López-Rodríguez ML, Morcillo MJ, Fernández E, Benhamú B, Tejada I, Ayala D, Viso A, Campillo M, Pardo L, Delgado M, Manzanares J, Fuentes JA.
    J Med Chem; 2005 Apr 07; 48(7):2548-58. PubMed ID: 15801844
    [Abstract] [Full Text] [Related]

  • 38. Benzimidazole derivatives. 2. Synthesis and structure-activity relationships of new azabicyclic benzimidazole-4-carboxylic acid derivatives with affinity for serotoninergic 5-HT(3) receptors.
    López-Rodríguez ML, Benhamú B, Morcillo MJ, Tejada ID, Orensanz L, Alfaro MJ, Martín MI.
    J Med Chem; 1999 Dec 02; 42(24):5020-8. PubMed ID: 10585211
    [Abstract] [Full Text] [Related]

  • 39. 1-cinnamyl-4-(2-methoxyphenyl)piperazines: synthesis, binding properties, and docking to dopamine (D(2)) and serotonin (5-HT(1A)) receptors.
    Penjisević J, Sukalović V, Andrić D, Kostić-Rajacić S, Soskić V, Roglić G.
    Arch Pharm (Weinheim); 2007 Sep 02; 340(9):456-65. PubMed ID: 17763374
    [Abstract] [Full Text] [Related]

  • 40. Correlating efficacy in rodent cognition models with in vivo 5-hydroxytryptamine1a receptor occupancy by a novel antagonist, (R)-N-(2-methyl-(4-indolyl-1-piperazinyl)ethyl)-N-(2-pyridinyl)-cyclohexane carboxamide (WAY-101405).
    Hirst WD, Andree TH, Aschmies S, Childers WE, Comery TA, Dawson LA, Day M, Feingold IB, Grauer SM, Harrison BL, Hughes ZA, Kao J, Kelly MG, van der Lee H, Rosenzweig-Lipson S, Saab AL, Smith DL, Sullivan K, Rizzo SJ, Tio C, Zhang MY, Schechter LE.
    J Pharmacol Exp Ther; 2008 Apr 02; 325(1):134-45. PubMed ID: 18182558
    [Abstract] [Full Text] [Related]

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