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113 related items for PubMed ID: 15379903

  • 1. Nicastrin expression in mouse peripheral tissues is not co-ordinated with presenilin and is high in muscle.
    Ilaya NT, Evin G, Masters CL, Culvenor JG.
    J Neurochem; 2004 Oct; 91(1):230-7. PubMed ID: 15379903
    [Abstract] [Full Text] [Related]

  • 2. Beta-amyloid secretases and beta-amloid degrading enzyme expression in lens.
    Li G, Percontino L, Sun Q, Qazi AS, Frederikse PH.
    Mol Vis; 2003 May 01; 9():179-83. PubMed ID: 12740567
    [Abstract] [Full Text] [Related]

  • 3. Transition-state analogue gamma-secretase inhibitors stabilize a 900 kDa presenilin/nicastrin complex.
    Evin G, Canterford LD, Hoke DE, Sharples RA, Culvenor JG, Masters CL.
    Biochemistry; 2005 Mar 22; 44(11):4332-41. PubMed ID: 15766262
    [Abstract] [Full Text] [Related]

  • 4. Gamma-secretase subunit composition and distribution in the presenilin wild-type and mutant mouse brain.
    Siman R, Salidas S.
    Neuroscience; 2004 Mar 22; 129(3):615-28. PubMed ID: 15541883
    [Abstract] [Full Text] [Related]

  • 5. Excess of nicastrin in brain results in heterozygosity having no effect on endogenous APP processing and amyloid peptide levels in vivo.
    Brijbassi S, Amtul Z, Newbigging S, Westaway D, St George-Hyslop P, Rozmahel RF.
    Neurobiol Dis; 2007 Feb 22; 25(2):291-6. PubMed ID: 17071095
    [Abstract] [Full Text] [Related]

  • 6. PEN-2 enhances gamma-cleavage after presenilin heterodimer formation.
    Shiraishi H, Sai X, Wang HQ, Maeda Y, Kurono Y, Nishimura M, Yanagisawa K, Komano H.
    J Neurochem; 2004 Sep 22; 90(6):1402-13. PubMed ID: 15341524
    [Abstract] [Full Text] [Related]

  • 7. Minor contribution of presenilin 2 for γ-secretase activity in mouse embryonic fibroblasts and adult mouse brain.
    Frånberg J, Svensson AI, Winblad B, Karlström H, Frykman S.
    Biochem Biophys Res Commun; 2011 Jan 07; 404(1):564-8. PubMed ID: 21146496
    [Abstract] [Full Text] [Related]

  • 8. Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation.
    Edbauer D, Winkler E, Haass C, Steiner H.
    Proc Natl Acad Sci U S A; 2002 Jun 25; 99(13):8666-71. PubMed ID: 12048259
    [Abstract] [Full Text] [Related]

  • 9. Rat nicastrin gene: cDNA isolation, mRNA variants and expression pattern analysis.
    Confaloni A, Crestini A, Albani D, Piscopo P, Campeggi LM, Terreni L, Tartaglia M, Forloni G.
    Brain Res Mol Brain Res; 2005 May 20; 136(1-2):12-22. PubMed ID: 15893582
    [Abstract] [Full Text] [Related]

  • 10. Presenilin 1 is involved in the maturation of beta-site amyloid precursor protein-cleaving enzyme 1 (BACE1).
    Kuzuya A, Uemura K, Kitagawa N, Aoyagi N, Kihara T, Ninomiya H, Ishiura S, Takahashi R, Shimohama S.
    J Neurosci Res; 2007 Jan 20; 85(1):153-65. PubMed ID: 17075903
    [Abstract] [Full Text] [Related]

  • 11. Presenilin modulates Pen-2 levels posttranslationally by protecting it from proteasomal degradation.
    Crystal AS, Morais VA, Fortna RR, Carlin D, Pierson TC, Wilson CA, Lee VM, Doms RW.
    Biochemistry; 2004 Mar 30; 43(12):3555-63. PubMed ID: 15035625
    [Abstract] [Full Text] [Related]

  • 12. gamma-Secretase complexes containing N- and C-terminal fragments of different presenilin origin retain normal gamma-secretase activity.
    Strömberg K, Hansson EM, Laudon H, Bergstedt S, Näslund J, Lundkvist J, Lendahl U.
    J Neurochem; 2005 Nov 30; 95(3):880-90. PubMed ID: 16135086
    [Abstract] [Full Text] [Related]

  • 13. Increased expression of the gamma-secretase components presenilin-1 and nicastrin in activated astrocytes and microglia following traumatic brain injury.
    Nadler Y, Alexandrovich A, Grigoriadis N, Hartmann T, Rao KS, Shohami E, Stein R.
    Glia; 2008 Apr 30; 56(5):552-67. PubMed ID: 18240300
    [Abstract] [Full Text] [Related]

  • 14. The presenilin C-terminus is required for ER-retention, nicastrin-binding and gamma-secretase activity.
    Kaether C, Capell A, Edbauer D, Winkler E, Novak B, Steiner H, Haass C.
    EMBO J; 2004 Dec 08; 23(24):4738-48. PubMed ID: 15549135
    [Abstract] [Full Text] [Related]

  • 15. Neprilysin activity and expression are controlled by nicastrin.
    Pardossi-Piquard R, Dunys J, Yu G, St George-Hyslop P, Alves da Costa C, Checler F.
    J Neurochem; 2006 May 08; 97(4):1052-6. PubMed ID: 16606360
    [Abstract] [Full Text] [Related]

  • 16. Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms.
    Bentahir M, Nyabi O, Verhamme J, Tolia A, Horré K, Wiltfang J, Esselmann H, De Strooper B.
    J Neurochem; 2006 Feb 08; 96(3):732-42. PubMed ID: 16405513
    [Abstract] [Full Text] [Related]

  • 17. Two domains within the first putative transmembrane domain of presenilin 1 differentially influence presenilinase and gamma-secretase activity.
    Brunkan AL, Martinez M, Wang J, Walker ES, Beher D, Shearman MS, Goate AM.
    J Neurochem; 2005 Sep 08; 94(5):1315-28. PubMed ID: 16001967
    [Abstract] [Full Text] [Related]

  • 18. Conserved residues in juxtamembrane region of the extracellular domain of nicastrin are essential for gamma-secretase complex formation.
    Walker ES, Martinez M, Wang J, Goate A.
    J Neurochem; 2006 Jul 08; 98(1):300-9. PubMed ID: 16805816
    [Abstract] [Full Text] [Related]

  • 19. CD147 is a regulatory subunit of the gamma-secretase complex in Alzheimer's disease amyloid beta-peptide production.
    Zhou S, Zhou H, Walian PJ, Jap BK.
    Proc Natl Acad Sci U S A; 2005 May 24; 102(21):7499-504. PubMed ID: 15890777
    [Abstract] [Full Text] [Related]

  • 20. CD147, a gamma-secretase associated protein is upregulated in Alzheimer's disease brain and its cellular trafficking is affected by presenilin-2.
    Nahalkova J, Volkmann I, Aoki M, Winblad B, Bogdanovic N, Tjernberg LO, Behbahani H.
    Neurochem Int; 2010 Jan 24; 56(1):67-76. PubMed ID: 19751784
    [Abstract] [Full Text] [Related]

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