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562 related items for PubMed ID: 15382039

  • 1. NS398 reduces hypoxia-inducible factor (HIF)-1alpha and HIF-1 activity: multiple-level effects involving cyclooxygenase-2 dependent and independent mechanisms.
    Zhong H, Willard M, Simons J.
    Int J Cancer; 2004 Nov 20; 112(4):585-95. PubMed ID: 15382039
    [Abstract] [Full Text] [Related]

  • 2. Prostaglandin E2 induces hypoxia-inducible factor-1alpha stabilization and nuclear localization in a human prostate cancer cell line.
    Liu XH, Kirschenbaum A, Lu M, Yao S, Dosoretz A, Holland JF, Levine AC.
    J Biol Chem; 2002 Dec 20; 277(51):50081-6. PubMed ID: 12401798
    [Abstract] [Full Text] [Related]

  • 3. Cyclooxygenase-2 increases hypoxia-inducible factor-1 and vascular endothelial growth factor to promote angiogenesis in gastric carcinoma.
    Huang SP, Wu MS, Shun CT, Wang HP, Hsieh CY, Kuo ML, Lin JT.
    J Biomed Sci; 2005 Dec 20; 12(1):229-41. PubMed ID: 15864753
    [Abstract] [Full Text] [Related]

  • 4. Upregulation of vascular endothelial growth factor by cobalt chloride-simulated hypoxia is mediated by persistent induction of cyclooxygenase-2 in a metastatic human prostate cancer cell line.
    Liu XH, Kirschenbaum A, Yao S, Stearns ME, Holland JF, Claffey K, Levine AC.
    Clin Exp Metastasis; 1999 Dec 20; 17(8):687-94. PubMed ID: 10919714
    [Abstract] [Full Text] [Related]

  • 5. Ibuprofen-mediated reduction of hypoxia-inducible factors HIF-1alpha and HIF-2alpha in prostate cancer cells.
    Palayoor ST, Tofilon PJ, Coleman CN.
    Clin Cancer Res; 2003 Aug 01; 9(8):3150-7. PubMed ID: 12912967
    [Abstract] [Full Text] [Related]

  • 6. Cyclooxygenase-2 inhibitor enhances whereas prostaglandin E2 inhibits the production of interferon-induced protein of 10 kDa in epidermoid carcinoma A431.
    Kanda N, Watanabe S.
    J Invest Dermatol; 2002 Nov 01; 119(5):1080-9. PubMed ID: 12445196
    [Abstract] [Full Text] [Related]

  • 7. Hypoxia up-regulates the effects of prostaglandin E2 on tumor angiogenesis in ovarian cancer cells.
    Zhu G, Saed GM, Deppe G, Diamond MP, Munkarah AR.
    Gynecol Oncol; 2004 Aug 01; 94(2):422-6. PubMed ID: 15297183
    [Abstract] [Full Text] [Related]

  • 8. Hypoxia-inducible factor 1alpha is involved in the prostaglandin metabolism of osteoarthritic cartilage through up-regulation of microsomal prostaglandin E synthase 1 in articular chondrocytes.
    Grimmer C, Pfander D, Swoboda B, Aigner T, Mueller L, Hennig FF, Gelse K.
    Arthritis Rheum; 2007 Dec 01; 56(12):4084-94. PubMed ID: 18050215
    [Abstract] [Full Text] [Related]

  • 9. The cyclooxygenase 2-selective inhibitor NS398 inhibits proliferation of oral carcinoma cell lines by mechanisms dependent and independent of reduced prostaglandin E2 synthesis.
    Minter HA, Eveson JW, Huntley S, Elder DJ, Hague A.
    Clin Cancer Res; 2003 May 01; 9(5):1885-97. PubMed ID: 12738747
    [Abstract] [Full Text] [Related]

  • 10. HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression.
    Laughner E, Taghavi P, Chiles K, Mahon PC, Semenza GL.
    Mol Cell Biol; 2001 Jun 01; 21(12):3995-4004. PubMed ID: 11359907
    [Abstract] [Full Text] [Related]

  • 11. IL-1beta-mediated up-regulation of HIF-1alpha via an NFkappaB/COX-2 pathway identifies HIF-1 as a critical link between inflammation and oncogenesis.
    Jung YJ, Isaacs JS, Lee S, Trepel J, Neckers L.
    FASEB J; 2003 Nov 01; 17(14):2115-7. PubMed ID: 12958148
    [Abstract] [Full Text] [Related]

  • 12. Mutant IkappaBalpha suppresses hypoxia-induced VEGF expression through downregulation of HIF-1alpha and COX-2 in human glioma cells.
    Kimba Y, Abe T, Wu JL, Inoue R, Fukiki M, Kohno K, Kobayashi H.
    Oncol Res; 2005 Nov 01; 15(3):139-49. PubMed ID: 16050135
    [Abstract] [Full Text] [Related]

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  • 15. Cyclooxygenase-2 inhibitor NS398 enhances antitumor effect of irradiation on hormone refractory human prostate carcinoma cells.
    Wen B, Deutsch E, Eschwege P, De Crevoisier R, Nasr E, Eschwege F, Bourhis J.
    J Urol; 2003 Nov 01; 170(5):2036-9. PubMed ID: 14532848
    [Abstract] [Full Text] [Related]

  • 16. The redox protein thioredoxin-1 (Trx-1) increases hypoxia-inducible factor 1alpha protein expression: Trx-1 overexpression results in increased vascular endothelial growth factor production and enhanced tumor angiogenesis.
    Welsh SJ, Bellamy WT, Briehl MM, Powis G.
    Cancer Res; 2002 Sep 01; 62(17):5089-95. PubMed ID: 12208766
    [Abstract] [Full Text] [Related]

  • 17. Association of hypoxia-inducible factors 1alpha and 2alpha with activated angiogenic pathways and prognosis in patients with endometrial carcinoma.
    Sivridis E, Giatromanolaki A, Gatter KC, Harris AL, Koukourakis MI, Tumor and Angiogenesis Research Group.
    Cancer; 2002 Sep 01; 95(5):1055-63. PubMed ID: 12209691
    [Abstract] [Full Text] [Related]

  • 18. Direct transcriptional up-regulation of cyclooxygenase-2 by hypoxia-inducible factor (HIF)-1 promotes colorectal tumor cell survival and enhances HIF-1 transcriptional activity during hypoxia.
    Kaidi A, Qualtrough D, Williams AC, Paraskeva C.
    Cancer Res; 2006 Jul 01; 66(13):6683-91. PubMed ID: 16818642
    [Abstract] [Full Text] [Related]

  • 19. Inhibition of cyclooxygenase-2 suppresses angiogenesis and the growth of prostate cancer in vivo.
    Liu XH, Kirschenbaum A, Yao S, Lee R, Holland JF, Levine AC.
    J Urol; 2000 Sep 01; 164(3 Pt 1):820-5. PubMed ID: 10953162
    [Abstract] [Full Text] [Related]

  • 20. Identification of a novel small-molecule inhibitor of the hypoxia-inducible factor 1 pathway.
    Tan C, de Noronha RG, Roecker AJ, Pyrzynska B, Khwaja F, Zhang Z, Zhang H, Teng Q, Nicholson AC, Giannakakou P, Zhou W, Olson JJ, Pereira MM, Nicolaou KC, Van Meir EG.
    Cancer Res; 2005 Jan 15; 65(2):605-12. PubMed ID: 15695405
    [Abstract] [Full Text] [Related]

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