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Journal Abstract Search

117 related items for PubMed ID: 1544839

  • 1. Bis-bioreductive agents as hypoxia-selective cytotoxins: nitracrine N-oxide.
    Wilson WR, Van Zijl P, Denny WA.
    Int J Radiat Oncol Biol Phys; 1992; 22(4):693-6. PubMed ID: 1544839
    [Abstract] [Full Text] [Related]

  • 2. Hypoxia-selective antitumor agents. 13. Effects of acridine substitution on the hypoxia-selective cytotoxicity and metabolic reduction of the bis-bioreductive agent nitracrine N-oxide.
    Lee HH, Wilson WR, Ferry DM, van Zijl P, Pullen SM, Denny WA.
    J Med Chem; 1996 Jun 21; 39(13):2508-17. PubMed ID: 8691448
    [Abstract] [Full Text] [Related]

  • 3. Comparison of aromatic and tertiary amine N-oxides of acridine DNA intercalators as bioreductive drugs. Cytotoxicity, DNA binding, cellular uptake, and metabolism.
    Siim BG, Hicks KO, Pullen SM, van Zijl PL, Denny WA, Wilson WR.
    Biochem Pharmacol; 2000 Oct 01; 60(7):969-78. PubMed ID: 10974206
    [Abstract] [Full Text] [Related]

  • 4. Nitracrine N-oxides: effects of variations in the nature of the side chain N-oxide on hypoxia-selective cytotoxicity.
    Lee HH, Wilson WR, Denny WA.
    Anticancer Drug Des; 1999 Dec 01; 14(6):487-97. PubMed ID: 10834270
    [Abstract] [Full Text] [Related]

  • 5. Tertiary amine N-oxides as bioreductive drugs: DACA N-oxide, nitracrine N-oxide and AQ4N.
    Wilson WR, Denny WA, Pullen SM, Thompson KM, Li AE, Patterson LH, Lee HH.
    Br J Cancer Suppl; 1996 Jul 01; 27():S43-7. PubMed ID: 8763844
    [Abstract] [Full Text] [Related]

  • 6. 5-Nitro-4-(N,N-dimethylaminopropylamino)quinoline (5-nitraquine), a new DNA-affinic hypoxic cell radiosensitizer and bioreductive agent: comparison with nitracrine.
    Wilson WR, Siim BG, Denny WA, van Zijl PL, Taylor ML, Chambers DM, Roberts PB.
    Radiat Res; 1992 Sep 01; 131(3):257-65. PubMed ID: 1438685
    [Abstract] [Full Text] [Related]

  • 7. Hypoxia-selective radiosensitization of mammalian cells by nitracrine, an electron-affinic DNA intercalator.
    Roberts PB, Anderson RF, Wilson WR.
    Int J Radiat Biol Relat Stud Phys Chem Med; 1987 Apr 01; 51(4):641-54. PubMed ID: 3495509
    [Abstract] [Full Text] [Related]

  • 8. Reductive metabolism and hypoxia-selective toxicity of nitracrine.
    Wilson WR, Denny WA, Stewart GM, Fenn A, Probert JC.
    Int J Radiat Oncol Biol Phys; 1986 Jul 01; 12(7):1235-8. PubMed ID: 3744944
    [Abstract] [Full Text] [Related]

  • 9. Hypoxia-selective antitumor agents. 4. Relationships between structure, physicochemical properties, and hypoxia-selective cytotoxicity for nitracrine analogues with varying side chains: the "iminoacridan hypothesis".
    Denny WA, Atwell GJ, Anderson RF, Wilson WR.
    J Med Chem; 1990 May 01; 33(5):1288-95. PubMed ID: 2329552
    [Abstract] [Full Text] [Related]

  • 10. Selective toxicity of nitracrine to hypoxic mammalian cells.
    Wilson WR, Denny WA, Twigden SJ, Baguley BC, Probert JC.
    Br J Cancer; 1984 Feb 01; 49(2):215-23. PubMed ID: 6696822
    [Abstract] [Full Text] [Related]

  • 11. Hypoxia-selective antitumor agents. 12. Nitrobenzyl quaternary salts as bioreductive prodrugs of the alkylating agent mechlorethamine.
    Tercel M, Wilson WR, Anderson RF, Denny WA.
    J Med Chem; 1996 Mar 01; 39(5):1084-94. PubMed ID: 8676343
    [Abstract] [Full Text] [Related]

  • 12. Metabolic and radiolytic reduction of 4-alkylamino-5-nitroquinoline bioreductive drugs. Relationship to hypoxia-selective cytotoxicity.
    Siim BG, Atwell GJ, Wilson WR.
    Biochem Pharmacol; 1994 Oct 18; 48(8):1593-604. PubMed ID: 7980625
    [Abstract] [Full Text] [Related]

  • 13. Hypoxia-selective antitumor agents. 2. Electronic effects of 4-substituents on the mechanisms of cytotoxicity and metabolic stability of nitracrine derivatives.
    Wilson WR, Thompson LH, Anderson RF, Denny WA.
    J Med Chem; 1989 Jan 18; 32(1):31-8. PubMed ID: 2909741
    [Abstract] [Full Text] [Related]

  • 14. The reaction between nitracrine and glutathione: implications for hypoxic cell radiosensitization and cytotoxicity.
    Wilson WR, Anderson RF.
    Int J Radiat Oncol Biol Phys; 1989 Apr 18; 16(4):1001-5. PubMed ID: 2703377
    [Abstract] [Full Text] [Related]

  • 15. Hypoxia-selective antitumor agents. 8. Bis(nitroimidazolyl)alkanecarboxamides: a new class of hypoxia-selective cytotoxins and hypoxic cell radiosensitisers.
    Hay MP, Wilson WR, Moselen JW, Palmer BD, Denny WA.
    J Med Chem; 1994 Feb 04; 37(3):381-91. PubMed ID: 8308864
    [Abstract] [Full Text] [Related]

  • 16. Cytotoxic palladium complexes of bioreductive quinoxaline N1,N4-dioxide prodrugs.
    Urquiola C, Vieites M, Torre MH, Cabrera M, Lavaggi ML, Cerecetto H, González M, Cerain AL, Monge A, Smircich P, Garat B, Gambino D.
    Bioorg Med Chem; 2009 Feb 15; 17(4):1623-9. PubMed ID: 19162490
    [Abstract] [Full Text] [Related]

  • 17. Hypoxia-selective antitumor agents. 14. Synthesis and hypoxic cell cytotoxicity of regioisomers of the hypoxia-selective cytotoxin 5-[N,N-bis(2-chloroethyl)amino]-2,4-dinitrobenzamide.
    Palmer BD, Wilson WR, Anderson RF, Boyd M, Denny WA.
    J Med Chem; 1996 Jun 21; 39(13):2518-28. PubMed ID: 8691449
    [Abstract] [Full Text] [Related]

  • 18. Oxygen dependence of the cytotoxicity and metabolic activation of 4-alkylamino-5-nitroquinoline bioreductive drugs.
    Siim BG, Atwell GJ, Wilson WR.
    Br J Cancer; 1994 Oct 21; 70(4):596-603. PubMed ID: 7917903
    [Abstract] [Full Text] [Related]

  • 19. Hypoxia-selective antitumor agents. 1. Relationships between structure, redox properties and hypoxia-selective cytotoxicity for 4-substituted derivatives of nitracrine.
    Wilson WR, Anderson RF, Denny WA.
    J Med Chem; 1989 Jan 21; 32(1):23-30. PubMed ID: 2909736
    [Abstract] [Full Text] [Related]

  • 20. Hypoxia-selective antitumor agents. 7. Metal complexes of aliphatic mustards as a new class of hypoxia-selective cytotoxins. Synthesis and evaluation of cobalt(III) complexes of bidentate mustards.
    Ware DC, Palmer BD, Wilson WR, Denny WA.
    J Med Chem; 1993 Jun 25; 36(13):1839-46. PubMed ID: 8515422
    [Abstract] [Full Text] [Related]

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