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Journal Abstract Search

190 related items for PubMed ID: 15454242

  • 1. Identification of 2,3-diaryl-pyrazolo[1,5-b]pyridazines as potent and selective cyclooxygenase-2 inhibitors.
    Beswick P, Bingham S, Bountra C, Brown T, Browning K, Campbell I, Chessell I, Clayton N, Collins S, Corfield J, Guntrip S, Haslam C, Lambeth P, Lucas F, Mathews N, Murkit G, Naylor A, Pegg N, Pickup E, Player H, Price H, Stevens A, Stratton S, Wiseman J.
    Bioorg Med Chem Lett; 2004 Nov 01; 14(21):5445-8. PubMed ID: 15454242
    [Abstract] [Full Text] [Related]

  • 2. 3-(2-Methoxytetrahydrofuran-2-yl)pyrazoles: a novel class of potent, selective cyclooxygenase-2 (COX-2) inhibitors.
    Ranatunge RR, Earl RA, Garvey DS, Janero DR, Letts LG, Martino AM, Murty MG, Richardson SK, Schwalb DJ, Young DV, Zemtseva IS.
    Bioorg Med Chem Lett; 2004 Dec 20; 14(24):6049-52. PubMed ID: 15546727
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  • 3. Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benze nesulfonamide (SC-58635, celecoxib).
    Penning TD, Talley JJ, Bertenshaw SR, Carter JS, Collins PW, Docter S, Graneto MJ, Lee LF, Malecha JW, Miyashiro JM, Rogers RS, Rogier DJ, Yu SS, AndersonGD, Burton EG, Cogburn JN, Gregory SA, Koboldt CM, Perkins WE, Seibert K, Veenhuizen AW, Zhang YY, Isakson PC.
    J Med Chem; 1997 Apr 25; 40(9):1347-65. PubMed ID: 9135032
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  • 6. Synthesis and selective cyclooxygenase-2 inhibitory activity of a series of novel, nitric oxide donor-containing pyrazoles.
    Ranatunge RR, Augustyniak M, Bandarage UK, Earl RA, Ellis JL, Garvey DS, Janero DR, Letts LG, Martino AM, Murty MG, Richardson SK, Schroeder JD, Shumway MJ, Tam SW, Trocha AM, Young DV.
    J Med Chem; 2004 Apr 22; 47(9):2180-93. PubMed ID: 15084117
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  • 7. Synthesis and biological evaluation of a new class of acyl derivatives of 3-amino-1-phenyl-4,5-dihydro-1H-pyrazol-5-one as potential dual cyclooxygenase (COX-1 and COX-2) and human lipoxygenase (5-LOX) inhibitors.
    Cusan C, Spalluto G, Prato M, Adams M, Bodensieck A, Bauer R, Tubaro A, Bernardi P, Da Ros T.
    Farmaco; 2005 Apr 22; 60(4):327-32. PubMed ID: 15848208
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  • 8. Synthesis and selective cyclooxygenase-2 (COX-2) inhibitory activity of a series of novel bicyclic pyrazoles.
    Ranatunge RR, Garvey DS, Janero DR, Letts LG, Martino AM, Murty MG, Richardson SK, Young DV, Zemetseva IS.
    Bioorg Med Chem; 2004 Mar 15; 12(6):1357-66. PubMed ID: 15018908
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  • 9. Novel terphenyls as selective cyclooxygenase-2 inhibitors and orally active anti-inflammatory agents.
    Li JJ, Norton MB, Reinhard EJ, Anderson GD, Gregory SA, Isakson PC, Koboldt CM, Masferrer JL, Perkins WE, Seibert K, Zhang Y, Zweifel BS, Reitz DB.
    J Med Chem; 1996 Apr 26; 39(9):1846-56. PubMed ID: 8627608
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  • 11. Design, synthesis, and biological evaluation of 6-substituted-3-(4-methanesulfonylphenyl)-4-phenylpyran-2-ones: a novel class of diarylheterocyclic selective cyclooxygenase-2 inhibitors.
    Praveen Rao PN, Amini M, Li H, Habeeb AG, Knaus EE.
    J Med Chem; 2003 Nov 06; 46(23):4872-82. PubMed ID: 14584938
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  • 12. Synthesis and biological activity of disubstituted 4,5-polymethylenepyrazoles as selective cyclooxygenase-2 inhibitors.
    Yu JW, Kim HH, Jahng Y.
    Pharmazie; 2002 May 06; 57(5):301-5. PubMed ID: 12061251
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  • 13. 2,3-Diarylcyclopentenones as orally active, highly selective cyclooxygenase-2 inhibitors.
    Black WC, Brideau C, Chan CC, Charleson S, Chauret N, Claveau D, Ethier D, Gordon R, Greig G, Guay J, Hughes G, Jolicoeur P, Leblanc Y, Nicoll-Griffith D, Ouimet N, Riendeau D, Visco D, Wang Z, Xu L, Prasit P.
    J Med Chem; 1999 Apr 08; 42(7):1274-81. PubMed ID: 10197970
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  • 14. Synthesis and structure-activity relationship of a new series of COX-2 selective inhibitors: 1,5-diarylimidazoles.
    Almansa C, Alfón J, de Arriba AF, Cavalcanti FL, Escamilla I, Gómez LA, Miralles A, Soliva R, Bartrolí J, Carceller E, Merlos M, García-Rafanell J.
    J Med Chem; 2003 Jul 31; 46(16):3463-75. PubMed ID: 12877584
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  • 15. Synthesis and cyclooxygenase-2 inhibiting property of 1,5-diarylpyrazoles with substituted benzenesulfonamide moiety as pharmacophore: Preparation of sodium salt for injectable formulation.
    Pal M, Madan M, Padakanti S, Pattabiraman VR, Kalleda S, Vanguri A, Mullangi R, Mamidi NV, Casturi SR, Malde A, Gopalakrishnan B, Yeleswarapu KR.
    J Med Chem; 2003 Sep 11; 46(19):3975-84. PubMed ID: 12954051
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  • 16. Design, synthesis, and biological evaluation of N-acetyl-2-(or 3-)carboxymethylbenzenesulfonamides as cyclooxygenase isozyme inhibitors.
    Chen QH, Rao PN, Knaus EE.
    Bioorg Med Chem; 2005 Aug 01; 13(15):4694-703. PubMed ID: 15914011
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  • 17. Synthesis of 4,5-diaryl-1H-pyrazole-3-ol derivatives as potential COX-2 inhibitors.
    Patel MV, Bell R, Majest S, Henry R, Kolasa T.
    J Org Chem; 2004 Oct 15; 69(21):7058-65. PubMed ID: 15471453
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  • 18. 2-hydroxymethyl-4-[5-(4-methoxyphenyl)-3-trifluoromethyl-1H-1-pyrazolyl]-1-benzenesulfonamide (DRF-4367): an orally active COX-2 inhibitor identified through pharmacophoric modulation.
    Singh SK, Vobbalareddy S, Kalleda SR, Rajjak SA, Casturi SR, Datla SR, Mamidi RN, Mullangi R, Bhamidipati R, Ramanujam R, Akella V, Yeleswarapu KR.
    Org Biomol Chem; 2004 Sep 07; 2(17):2442-50. PubMed ID: 15326524
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  • 19. Synthesis and structure-activity relationship of novel, highly potent metharyl and methcycloalkyl cyclooxygenase-2 (COX-2) selective inhibitors.
    Khanapure SP, Garvey DS, Young DV, Ezawa M, Earl RA, Gaston RD, Fang X, Murty M, Martino A, Shumway M, Trocha M, Marek P, Tam SW, Janero DR, Letts LG.
    J Med Chem; 2003 Dec 04; 46(25):5484-504. PubMed ID: 14640557
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  • 20. 1,5-Diarylpyrrole-3-acetic acids and esters as novel classes of potent and highly selective cyclooxygenase-2 inhibitors.
    Biava M, Porretta GC, Cappelli A, Vomero S, Manetti F, Botta M, Sautebin L, Rossi A, Makovec F, Anzini M.
    J Med Chem; 2005 May 05; 48(9):3428-32. PubMed ID: 15857149
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