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506 related items for PubMed ID: 15468057

  • 1. PTEN permits acute increases in D3-phosphoinositide levels following TCR stimulation but inhibits distal signaling events by reducing the basal activity of Akt.
    Seminario MC, Precht P, Bunnell SC, Warren SE, Morris CM, Taub D, Wange RL.
    Eur J Immunol; 2004 Nov; 34(11):3165-75. PubMed ID: 15468057
    [Abstract] [Full Text] [Related]

  • 2. Deficiency of PTEN in Jurkat T cells causes constitutive localization of Itk to the plasma membrane and hyperresponsiveness to CD3 stimulation.
    Shan X, Czar MJ, Bunnell SC, Liu P, Liu Y, Schwartzberg PL, Wange RL.
    Mol Cell Biol; 2000 Sep; 20(18):6945-57. PubMed ID: 10958690
    [Abstract] [Full Text] [Related]

  • 3. Evidence that SHIP-1 contributes to phosphatidylinositol 3,4,5-trisphosphate metabolism in T lymphocytes and can regulate novel phosphoinositide 3-kinase effectors.
    Freeburn RW, Wright KL, Burgess SJ, Astoul E, Cantrell DA, Ward SG.
    J Immunol; 2002 Nov 15; 169(10):5441-50. PubMed ID: 12421919
    [Abstract] [Full Text] [Related]

  • 4. The tumor suppressor PTEN regulates T cell survival and antigen receptor signaling by acting as a phosphatidylinositol 3-phosphatase.
    Wang X, Gjörloff-Wingren A, Saxena M, Pathan N, Reed JC, Mustelin T.
    J Immunol; 2000 Feb 15; 164(4):1934-9. PubMed ID: 10657643
    [Abstract] [Full Text] [Related]

  • 5. PTEN, but not SHIP2, suppresses insulin signaling through the phosphatidylinositol 3-kinase/Akt pathway in 3T3-L1 adipocytes.
    Tang X, Powelka AM, Soriano NA, Czech MP, Guilherme A.
    J Biol Chem; 2005 Jun 10; 280(23):22523-9. PubMed ID: 15824124
    [Abstract] [Full Text] [Related]

  • 6. Akt regulates COX-2 mRNA and protein expression in mutated-PTEN human endometrial cancer cells.
    St-Germain ME, Gagnon V, Mathieu I, Parent S, Asselin E.
    Int J Oncol; 2004 May 10; 24(5):1311-24. PubMed ID: 15067356
    [Abstract] [Full Text] [Related]

  • 7. Preferential killing of PTEN-null myelomas by PI3K inhibitors through Akt pathway.
    Zhang J, Choi Y, Mavromatis B, Lichtenstein A, Li W.
    Oncogene; 2003 Sep 18; 22(40):6289-95. PubMed ID: 13679867
    [Abstract] [Full Text] [Related]

  • 8. The PI 3-kinase/Akt signaling pathway is activated due to aberrant Pten expression and targets transcription factors NF-kappaB and c-Myc in pancreatic cancer cells.
    Asano T, Yao Y, Zhu J, Li D, Abbruzzese JL, Reddy SA.
    Oncogene; 2004 Nov 11; 23(53):8571-80. PubMed ID: 15467756
    [Abstract] [Full Text] [Related]

  • 9. Signaling pathways of D3-phosphoinositide-binding kinases in T cells and their regulation by PTEN.
    Seminario MC, Wange RL.
    Semin Immunol; 2002 Feb 11; 14(1):27-36. PubMed ID: 11884228
    [Abstract] [Full Text] [Related]

  • 10. Regulation of phosphoinositide metabolism, Akt phosphorylation, and glucose transport by PTEN (phosphatase and tensin homolog deleted on chromosome 10) in 3T3-L1 adipocytes.
    Ono H, Katagiri H, Funaki M, Anai M, Inukai K, Fukushima Y, Sakoda H, Ogihara T, Onishi Y, Fujishiro M, Kikuchi M, Oka Y, Asano T.
    Mol Endocrinol; 2001 Aug 11; 15(8):1411-22. PubMed ID: 11463863
    [Abstract] [Full Text] [Related]

  • 11. Abnormal PTEN expression in portal hypertensive gastric mucosa: a key to impaired PI 3-kinase/Akt activation and delayed injury healing?
    Tsugawa K, Jones MK, Akahoshi T, Moon WS, Maehara Y, Hashizume M, Sarfeh IJ, Tarnawski AS.
    FASEB J; 2003 Dec 11; 17(15):2316-8. PubMed ID: 14525948
    [Abstract] [Full Text] [Related]

  • 12. PTEN and TNF-alpha regulation of the intestinal-specific Cdx-2 homeobox gene through a PI3K, PKB/Akt, and NF-kappaB-dependent pathway.
    Kim S, Domon-Dell C, Wang Q, Chung DH, Di Cristofano A, Pandolfi PP, Freund JN, Evers BM.
    Gastroenterology; 2002 Oct 11; 123(4):1163-78. PubMed ID: 12360479
    [Abstract] [Full Text] [Related]

  • 13. Loss of PTEN expression does not contribute to PDK-1 activity and PKC activation-loop phosphorylation in Jurkat leukaemic T cells.
    Freeley M, Park J, Yang KJ, Wange RL, Volkov Y, Kelleher D, Long A.
    Cell Signal; 2007 Dec 11; 19(12):2444-57. PubMed ID: 17826953
    [Abstract] [Full Text] [Related]

  • 14. Leptin induces endothelial cell migration through Akt, which is inhibited by PPARgamma-ligands.
    Goetze S, Bungenstock A, Czupalla C, Eilers F, Stawowy P, Kintscher U, Spencer-Hänsch C, Graf K, Nürnberg B, Law RE, Fleck E, Gräfe M.
    Hypertension; 2002 Nov 11; 40(5):748-54. PubMed ID: 12411472
    [Abstract] [Full Text] [Related]

  • 15. Mycobacterial antigen(s) induce anergy by altering TCR- and TCR/CD28-induced signalling events: insights into T-cell unresponsiveness in leprosy.
    Dagur PK, Sharma B, Kumar G, Khan NA, Katoch VM, Sengupta U, Joshi B.
    Mol Immunol; 2010 Feb 11; 47(5):943-52. PubMed ID: 20018378
    [Abstract] [Full Text] [Related]

  • 16. Loss of tumor suppressor p53 decreases PTEN expression and enhances signaling pathways leading to activation of activator protein 1 and nuclear factor kappaB induced by UV radiation.
    Wang J, Ouyang W, Li J, Wei L, Ma Q, Zhang Z, Tong Q, He J, Huang C.
    Cancer Res; 2005 Aug 01; 65(15):6601-11. PubMed ID: 16061640
    [Abstract] [Full Text] [Related]

  • 17. 70Z/3 Cbl induces PLC gamma 1 activation in T lymphocytes via an alternate Lat- and Slp-76-independent signaling mechanism.
    Graham LJ, Verí MC, DeBell KE, Noviello C, Rawat R, Jen S, Bonvini E, Rellahan B.
    Oncogene; 2003 Apr 24; 22(16):2493-503. PubMed ID: 12717426
    [Abstract] [Full Text] [Related]

  • 18. The inducible expression of the tumor suppressor gene PTEN promotes apoptosis and decreases cell size by inhibiting the PI3K/Akt pathway in Jurkat T cells.
    Xu Z, Stokoe D, Kane LP, Weiss A.
    Cell Growth Differ; 2002 Jul 24; 13(7):285-96. PubMed ID: 12133897
    [Abstract] [Full Text] [Related]

  • 19. PTEN, but not SHIP and SHIP2, suppresses the PI3K/Akt pathway and induces growth inhibition and apoptosis of myeloma cells.
    Choi Y, Zhang J, Murga C, Yu H, Koller E, Monia BP, Gutkind JS, Li W.
    Oncogene; 2002 Aug 08; 21(34):5289-300. PubMed ID: 12149650
    [Abstract] [Full Text] [Related]

  • 20. Restoration of SHIP activity in a human leukemia cell line downregulates constitutively activated phosphatidylinositol 3-kinase/Akt/GSK-3beta signaling and leads to an increased transit time through the G1 phase of the cell cycle.
    Horn S, Endl E, Fehse B, Weck MM, Mayr GW, Jücker M.
    Leukemia; 2004 Nov 08; 18(11):1839-49. PubMed ID: 15457186
    [Abstract] [Full Text] [Related]

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