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320 related items for PubMed ID: 15482948

  • 1. Potent inhibitors of the HIV-1 protease incorporating cyclic urea P1-P2 scaffold.
    Kazmierski WM, Furfine E, Gray-Nunez Y, Spaltenstein A, Wright L.
    Bioorg Med Chem Lett; 2004 Nov 15; 14(22):5685-7. PubMed ID: 15482948
    [Abstract] [Full Text] [Related]

  • 2. Discovery of potent pyrrolidone-based HIV-1 protease inhibitors with enhanced drug-like properties.
    Kazmierski WM, Andrews W, Furfine E, Spaltenstein A, Wright L.
    Bioorg Med Chem Lett; 2004 Nov 15; 14(22):5689-92. PubMed ID: 15482949
    [Abstract] [Full Text] [Related]

  • 3. Synthesis and antiviral activity of P1' arylsulfonamide azacyclic urea HIV protease inhibitors.
    Huang PP, Randolph JT, Klein LL, Vasavanonda S, Dekhtyar T, Stoll VS, Kempf DJ.
    Bioorg Med Chem Lett; 2004 Aug 02; 14(15):4075-8. PubMed ID: 15225729
    [Abstract] [Full Text] [Related]

  • 4. Discovery of HIV-1 protease inhibitors with picomolar affinities incorporating N-aryl-oxazolidinone-5-carboxamides as novel P2 ligands.
    Ali A, Reddy GS, Cao H, Anjum SG, Nalam MN, Schiffer CA, Rana TM.
    J Med Chem; 2006 Dec 14; 49(25):7342-56. PubMed ID: 17149864
    [Abstract] [Full Text] [Related]

  • 5. New, potent P1/P2-morpholinone-based HIV-protease inhibitors.
    Kazmierski WM, Furfine E, Spaltenstein A, Wright LL.
    Bioorg Med Chem Lett; 2006 Oct 01; 16(19):5226-30. PubMed ID: 16904316
    [Abstract] [Full Text] [Related]

  • 6. Design, synthesis, and biological evaluation of monopyrrolinone-based HIV-1 protease inhibitors possessing augmented P2' side chains.
    Smith AB, Charnley AK, Harada H, Beiger JJ, Cantin LD, Kenesky CS, Hirschmann R, Munshi S, Olsen DB, Stahlhut MW, Schleif WA, Kuo LC.
    Bioorg Med Chem Lett; 2006 Feb 15; 16(4):859-63. PubMed ID: 16298527
    [Abstract] [Full Text] [Related]

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  • 8. A mechanistic study of 3-aminoindazole cyclic urea HIV-1 protease inhibitors using comparative QSAR.
    Garg R, Bhhatarai B.
    Bioorg Med Chem; 2004 Nov 15; 12(22):5819-31. PubMed ID: 15498658
    [Abstract] [Full Text] [Related]

  • 9. Design and synthesis of novel P2 substituents in diol-based HIV protease inhibitors.
    Adrian Meredith J, Wallberg H, Vrang L, Oscarson S, Parkes K, Hallberg A, Samuelsson B.
    Eur J Med Chem; 2010 Jan 15; 45(1):160-70. PubMed ID: 19926360
    [Abstract] [Full Text] [Related]

  • 10. Cyclic HIV protease inhibitors: synthesis, conformational analysis, P2/P2' structure-activity relationship, and molecular recognition of cyclic ureas.
    Lam PY, Ru Y, Jadhav PK, Aldrich PE, DeLucca GV, Eyermann CJ, Chang CH, Emmett G, Holler ER, Daneker WF, Li L, Confalone PN, McHugh RJ, Han Q, Li R, Markwalder JA, Seitz SP, Sharpe TR, Bacheler LT, Rayner MM, Klabe RM, Shum L, Winslow DL, Kornhauser DM, Hodge CN.
    J Med Chem; 1996 Aug 30; 39(18):3514-25. PubMed ID: 8784449
    [Abstract] [Full Text] [Related]

  • 11. Design, biologic evaluation, and SAR of novel pseudo-peptide incorporating benzheterocycles as HIV-1 protease inhibitors.
    He M, Zhang H, Yao X, Eckart M, Zuo E, Yang M.
    Chem Biol Drug Des; 2010 Aug 30; 76(2):174-80. PubMed ID: 20572811
    [Abstract] [Full Text] [Related]

  • 12. Synthesis of novel cyclic urea based HIV-1 protease inhibitors.
    Nugiel DA, Reese K.
    Drug Des Discov; 1995 Nov 30; 13(2):83-7. PubMed ID: 8872453
    [Abstract] [Full Text] [Related]

  • 13. Combinatorial design of nonsymmetrical cyclic urea inhibitors of aspartic protease of HIV-1.
    Frecer V, Burello E, Miertus S.
    Bioorg Med Chem; 2005 Sep 15; 13(18):5492-501. PubMed ID: 16054372
    [Abstract] [Full Text] [Related]

  • 14. Novel inhibitors of HIV protease: design, synthesis and biological evaluation of picomolar inhibitors containing cyclic P1/P2 scaffolds.
    Spaltenstein A, Almond MR, Bock WJ, Cleary DG, Furfine ES, Hazen RJ, Kazmierski WM, Salituro FG, Tung RD, Wright LL.
    Bioorg Med Chem Lett; 2000 Jun 05; 10(11):1159-62. PubMed ID: 10866371
    [Abstract] [Full Text] [Related]

  • 15. Synthesis and activity of N-acyl azacyclic urea HIV-1 protease inhibitors with high potency against multiple drug resistant viral strains.
    Zhao C, Sham HL, Sun M, Stoll VS, Stewart KD, Lin S, Mo H, Vasavanonda S, Saldivar A, Park C, McDonald EJ, Marsh KC, Klein LL, Kempf DJ, Norbeck DW.
    Bioorg Med Chem Lett; 2005 Dec 15; 15(24):5499-503. PubMed ID: 16203141
    [Abstract] [Full Text] [Related]

  • 16. Stereoisomers of cyclic urea HIV-1 protease inhibitors: synthesis and binding affinities.
    Kaltenbach RF, Nugiel DA, Lam PY, Klabe RM, Seitz SP.
    J Med Chem; 1998 Dec 03; 41(25):5113-7. PubMed ID: 9836627
    [Abstract] [Full Text] [Related]

  • 17. Counteracting HIV-1 protease drug resistance: structural analysis of mutant proteases complexed with XV638 and SD146, cyclic urea amides with broad specificities.
    Ala PJ, Huston EE, Klabe RM, Jadhav PK, Lam PY, Chang CH.
    Biochemistry; 1998 Oct 27; 37(43):15042-9. PubMed ID: 9790666
    [Abstract] [Full Text] [Related]

  • 18. Targeting the open-flap conformation of HIV-1 protease with pyrrolidine-based inhibitors.
    Böttcher J, Blum A, Dörr S, Heine A, Diederich WE, Klebe G.
    ChemMedChem; 2008 Sep 27; 3(9):1337-44. PubMed ID: 18720485
    [Abstract] [Full Text] [Related]

  • 19. Hydrophobicity in the design of P2/P2' tetrahydropyrimidinone HIV protease inhibitors.
    Garg R, Patel D.
    Bioorg Med Chem Lett; 2005 Aug 15; 15(16):3767-70. PubMed ID: 15993582
    [Abstract] [Full Text] [Related]

  • 20. Structure-based design: synthesis and biological evaluation of a series of novel cycloamide-derived HIV-1 protease inhibitors.
    Ghosh AK, Swanson LM, Cho H, Leshchenko S, Hussain KA, Kay S, Walters DE, Koh Y, Mitsuya H.
    J Med Chem; 2005 May 19; 48(10):3576-85. PubMed ID: 15887965
    [Abstract] [Full Text] [Related]

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